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. 1988 Dec;4(4):487-94.
doi: 10.1007/BF00117776.

Synaptonemal complex damage as a measure of genotoxicity at meiosis

J W Allen  1 , P A Poorman, L C Backer, J B Gibson, B Westbrook-Collins, M J Moses
Affiliations

Synaptonemal complex damage as a measure of genotoxicity at meiosis

J W Allen et al. Cell Biol Toxicol. 1988 Dec.

Abstract

Synaptonemal complex aberrations can provide a sensitive measure of chemical-specific alterations to meiotic chromosomes. Mitomycin C, cyclophosphamide, amsacrine, ellipticine, colchicine, vinblastine sulfate, and cis-platin exposures in mice have been shown to cause various patterns of synaptonemal complex structural damage and synaptic irregularity. These effects are suggestive of abnormal homologue pairing/synapsis/recombination effects which, theoretically, could be implicated in mechanisms leading to aneuploidy and other potentially heritable chromosomal disorders.

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