Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Dec:97:445-457.
doi: 10.1016/j.trac.2017.10.005. Epub 2017 Oct 13.

Nanomaterial-based biosensors for detection of pathogenic virus

Ahad Mokhtarzadeh  1   2 , Reza Eivazzadeh-Keihan  3 , Paria Pashazadeh  4 , Maryam Hejazi  5 , Nasrin Gharaatifar  2 , Mohammad Hasanzadeh  6 , Behzad Baradaran  1 , Miguel de la Guardia  7
Affiliations
Review

Nanomaterial-based biosensors for detection of pathogenic virus

Ahad Mokhtarzadeh et al. Trends Analyt Chem. 2017 Dec.

Abstract

Viruses are real menace to human safety that cause devastating viral disease. The high prevalence of these diseases is due to improper detecting tools. Therefore, there is a remarkable demand to identify viruses in a fast, selective and accurate way. Several biosensors have been designed and commercialized for detection of pathogenic viruses. However, they present many challenges. Nanotechnology overcomes these challenges and performs direct detection of molecular targets in real time. In this overview, studies concerning nanotechnology-based biosensors for pathogenic virus detection have been summarized, paying special attention to biosensors based on graphene oxide, silica, carbon nanotubes, gold, silver, zinc oxide and magnetic nanoparticles, which could pave the way to detect viral diseases and provide healthy life for infected patients.

Keywords: Biosensor; Electrochemistry; Nanomaterial; Optical detection; Virus.

PubMed Disclaimer

Figures

Scheme 1
Scheme 1
Schematic diagram of biosensor for detection of pathogenic viruses (analyte).
Fig. 1
Fig. 1
Schematic illustration of HIV capturing/imaging strategy using dual-stain imaging technique based on streptavidin conjugated Qdot525 and Qdot655 for detection of HIV1 gp120 antigen.
Fig. 2
Fig. 2
Schematic process of preparing modified electrode by encapsulation of enzyme in silica matrix.
Fig. 3
Fig. 3
Process of DNA hybridization on GO to build a modified electrode.
Fig. 4
Fig. 4
Design of a modified electrode with two-dimensional (2D) core–shell structure of (Au@Ag) NPs array as substrate.
Fig. 5
Fig. 5
ZnO nanowire-based biosensor for detection of human immunodeficiency virus (HIV). (a) Digital and microscopy image of ZnO nanowire DNA sensor; (b) SEM image of ZnO nanowires; (c) schematic explanation of biosensor design; (d) performance of ZnO nanowire DNA sensor regarding external strains.
Fig. 6
Fig. 6
Preparation of a biosensor based on graphene/zinc oxide nanocomposite and its application in detection of Influenza H5 gene.
Fig. 7
Fig. 7
Nanoprobe/nanoporous membrane system for detection ebola virus oligonucleotide.
Fig. 8
Fig. 8
Alumina nanobiosensor for the to precise detection of Dengue 2 virus using immunoglobulin G.
See this image and copyright information in PMC

References

    1. Katayama Y., Ohgi T., Mitoma Y., Hifumi E., Egashira N. Detection of influenza virus by a biosensor based on the method combining electrochemiluminescence on binary SAMs modified Au electrode with an immunoliposome encapsulating Ru (II) complex. Anal. Bioanal. Chem. 2016 doi: 10.1007/s00216-016-9587-8. - DOI - PubMed
    1. Laurence J.C. Hepatitis A and B immunizations of individuals infected with human immunodeficiency virus. Am. J. Med. 2005;118(Suppl. 10A):75S–83S. - PubMed
    1. Mokhtarzadeh A., Bouzari M. Detection of the frequency of the novel TT virus by PCR and its role in the induction of hepatic injuries in blood donors in West Azarbaijan, Iran. IJBC. 2009;5:25–31.
    1. Vidic J., Manzano M., Chang C.-M., Jaffrezic-Renault N. Advanced biosensors for detection of pathogens related to livestock and poultry. Vet. Res. 2017;48:11. - PMC - PubMed
    1. Iqbal S.S., Mayo M.W., Bruno J.G., Bronk B.V., Batt C.A., Chambers J.P. A review of molecular recognition technologies for detection of biological threat agents. Biosens. Bioelectron. 2000;15:549–578. - PubMed

LinkOut - more resources