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Comment
. 2020 Apr 13;37(4):424-425.
doi: 10.1016/j.ccell.2020.03.020.

The "Risk" in Pediatric Low-Grade Glioma

Jason Fangusaro  1 , Pratiti Bandopadhayay  2
Affiliations
Free article
Comment

The "Risk" in Pediatric Low-Grade Glioma

Jason Fangusaro et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Ryall et al. report on the largest clinically and molecularly characterized cohort of pediatric low-grade gliomas (pLGGs) published to date. They provide new insight into the pLGG molecular landscape and a novel risk stratification system with the potential to revolutionize prognostication and impact treatment.

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Conflict of interest statement

Declaration of Interests P.B. reports research grants from the Novartis Institute of Biomedical Research. Patents, royalties, and other intellectual property include Compositions and Methods for Screening Pediatric Gliomas and Methods of Treatment Thereof (international application No. WO/2017/132574, PCT/US2017/015448, filed 1/27/2017).

Comment on

  • Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas.
    Ryall S, Zapotocky M, Fukuoka K, Nobre L, Guerreiro Stucklin A, Bennett J, Siddaway R, Li C, Pajovic S, Arnoldo A, Kowalski PE, Johnson M, Sheth J, Lassaletta A, Tatevossian RG, Orisme W, Qaddoumi I, Surrey LF, Li MM, Waanders AJ, Gilheeney S, Rosenblum M, Bale T, Tsang DS, Laperriere N, Kulkarni A, Ibrahim GM, Drake J, Dirks P, Taylor MD, Rutka JT, Laughlin S, Shroff M, Shago M, Hazrati LN, D'Arcy C, Ramaswamy V, Bartels U, Huang A, Bouffet E, Karajannis MA, Santi M, Ellison DW, Tabori U, Hawkins C. Ryall S, et al. Cancer Cell. 2020 Apr 13;37(4):569-583.e5. doi: 10.1016/j.ccell.2020.03.011. Cancer Cell. 2020. PMID: 32289278 Free PMC article.

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