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Comment
. 2020 Apr 13;37(4):428-430.
doi: 10.1016/j.ccell.2020.03.021.

Immuno-Oncology beyond TILs: Unleashing TILCs

Olivier Demaria  1 , Eric Vivier  2
Affiliations
Free article
Comment

Immuno-Oncology beyond TILs: Unleashing TILCs

Olivier Demaria et al. Cancer Cell. .
Free article

Abstract

Innate lymphoid cells (ILCs) are detected in multiple tumor types, but their contribution to tumor immunity remains unclear. Moral et al. show that a subset of tumor ILCs (TILCs) may participate in an organ-specific immune response and can be unleashed by PD-1 blockers to sustain tumor-specific T cell responses.

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Conflict of interest statement

Declaration of Interests O.D. and E.V. are employees of Innate Pharma.

Comment on

  • ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity.
    Moral JA, Leung J, Rojas LA, Ruan J, Zhao J, Sethna Z, Ramnarain A, Gasmi B, Gururajan M, Redmond D, Askan G, Bhanot U, Elyada E, Park Y, Tuveson DA, Gönen M, Leach SD, Wolchok JD, DeMatteo RP, Merghoub T, Balachandran VP. Moral JA, et al. Nature. 2020 Mar;579(7797):130-135. doi: 10.1038/s41586-020-2015-4. Epub 2020 Feb 19. Nature. 2020. PMID: 32076273 Free PMC article.

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