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. 2021 May;19(5):1058-1060.e1.
doi: 10.1016/j.cgh.2020.03.069. Epub 2020 Apr 11.

Esophagogastric Junction Opening Parameters Are Consistently Abnormal in Untreated Achalasia

Katharine P Rooney  1 , Alexandra J Baumann  1 , Erica Donnan  1 , Wenjun Kou  1 , Joseph R Triggs  1 , Jacqueline Prescott  1 , Alex Decorrevont  1 , Emily Dorian  1 , Peter J Kahrilas  1 , John E Pandolfino  1 , Dustin A Carlson  2
Affiliations

Esophagogastric Junction Opening Parameters Are Consistently Abnormal in Untreated Achalasia

Katharine P Rooney et al. Clin Gastroenterol Hepatol. 2021 May.

Abstract

Achalasia is a disorder of impaired lower esophageal sphincter (LES) relaxation and failed peristalsis traditionally characterized by manometry.1 As impaired LES relaxation is a mechanism of reduced esophagogastric junction (EGJ) opening, abnormally reduced EGJ distensibility assessed with functional luminal imaging probe (FLIP) was reported among patients with untreated achalasia.2-5 Therefore, we aimed to describe the performance characteristics of EGJ opening parameters on FLIP panometry among a large cohort of treatment-naïve achalasia patients.

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Conflict of interest statement

Conflicts of interest:

Dustin A. Carlson, Peter J. Kahrilas, and John E. Pandolfino hold shared intellectual property rights and ownership surrounding FLIP panometry systems, methods, and apparatus with Medtronic Inc.

Dustin A. Carlson: Medtronic (Speaking. Consulting)

Wenjun Kou: Crospon, Inc Consulting)

Peter J. Kahrilas: Ironwood (Consulting)

John E. Pandolfino: Crospon, Inc (stock options), Given Imaging (Consultant, Grant, Speaking), Sandhill Scientific (Consulting, Speaking), Takeda (Speaking), Astra Zeneca (Speaking), Medtronic (Speaking. Consulting), Torax (Speaking, Consulting), Ironwood (Consulting), Impleo (Grant).

None: Katharine P. Rooney, Alexandra J. Baumann, Erica Donnan, Joseph R. Triggs Jacqueline Prescott, Alex Decorrevont, Emily Dorian

Figures

Figure.
Figure.. Esophagogastric junction (EGJ) opening in achalasia and asymptomatic volunteers.
Values reflect measures obtained over the course of the 60ml fill volume during the functional luminal imaging probe (FLIP) panometry study. Median EGJ-diameter was transformed from median CSA via assumption of a circular lumen. In achalasia, the median (5-95th CI) EGJ-diameter was 6.0 (4.8–9.7) mm and median intraballoon pressure was 32 (16–69) mmHg. In controls, the median (5–95th CI) EGJ-diameter was 18.1 (12.9–21.9) mm and median intraballoon pressure was 44 (31–64) mmHg; P-values <0.001. Figure used with permission from the Esophageal Center at Northwestern.
See this image and copyright information in PMC

References

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