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. 2020 Aug;122(2):306-314.
doi: 10.1002/jso.25929. Epub 2020 Apr 14.

The impact of wait times on oncological outcome in high-risk patients with endometrial cancer

Cristina Mitric  1 , Emad Matanes  1   2 , Michel Wissing  3 , Zainab Amajoud  1 , Jeremie Abitbol  1 , Amber Yasmeen  2 , Vanessa López-Ozuna  2 , Neta Eisenberg  4 , Ido Laskov  5 , Susie Lau  1 , Shannon Salvador  1 , Walter H Gotlieb  1   2 , Liron Kogan  1   2   6
Affiliations

The impact of wait times on oncological outcome in high-risk patients with endometrial cancer

Cristina Mitric et al. J Surg Oncol. 2020 Aug.

Abstract

Objective: To evaluate the impact of surgical wait times on outcome of patients with grade 3 endometrial cancer.

Methods: All consecutive patients surgically treated for grade 3 endometrial cancer between 2007 and 2015 were included. Patients were divided into two groups based on the time interval between endometrial biopsy and surgery: wait time from biopsy to surgery ≤12 weeks (84 days) vs more than 12 weeks. Survival analyses were conducted using log-rank tests and Cox proportional hazards models.

Results: A total of 136 patients with grade 3 endometrial cancer were followed for a median of 5.6 years. Fifty-one women (37.5%) waited more than 12 weeks for surgery. Prolonged surgical wait times were not associated with advanced stage at surgery, positive lymph nodes, increased lymphovascular space invasion, and tumor size (P = .8, P = 1.0, P = .2, P = .9, respectively). In multivariable analysis adjusted for clinical and pathological factors, wait times did not significantly affect disease-specific survival (adjusted hazard ratio [HR]: 1.2, 95% confidence interval [CI], 0.6-2.5, P = .6), overall survival (HR: 1.1, 95% CI, 0.6-2.1, P = .7), or progression-free survival (HR: 0.9, 95% CI, 0.5-1.7, P = .8).

Conclusion: Prolonged surgical wait time for poorly differentiated endometrial cancer seemed to have a limited impact on clinical outcomes compared to biological factors.

Keywords: endometrial cancer; high-grade; hysterectomy; oncological outcome; survival; wait time.

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