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. 2020 Apr;18(4):325-332.
doi: 10.1111/ddg.14060.

Sexually transmitted coinfections in patients with anogenital warts - a retrospective analysis of 196 patients

Simon M Mueller  1 , Sheryl Menzi  1 , André B Kind  2 , Annette Blaich  3 , Michael Bayer  1   4 , Alexander Navarini  1 , Peter Itin  1 , Oliver Brandt  1
Affiliations

Sexually transmitted coinfections in patients with anogenital warts - a retrospective analysis of 196 patients

Simon M Mueller et al. J Dtsch Dermatol Ges. 2020 Apr.

Abstract

Background and objectives: Anogenital warts (AGWs) are most commonly caused by low-risk human papillomavirus (HPV) types, and although they are the most frequent viral sexually transmitted infections (STIs), little is known about STI coinfections in affected patients. We therefore sought to assess STI coinfection rates in patients with AGW, specify STI coinfections and calculate the number needed to screen (NNS) for each STI.

Methods: A retrospective cross-sectional study analyzing data sets from AGW patients treated in our clinic between 2008-2016.

Results: 142/196 (72 %) patients had been variably screened for infections with HIV, HBV and HCV, Treponema pallidum, Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium and HSV. The STI coinfection rate in all tested patients was 24.6 %, yielding an NNS of 4.1 to detect any STI. Of note, the coinfection rate did not differ significantly between heterosexual men, homosexual men and women, respectively. The NNS for syphilis was 8.4, for HIV 14.0, for HCV 28.5 and for HBV 39.0. The NNS for asymptomatic patients tested for HSV, Chlamydia trachomatis and Mycoplasma genitalium were 1.4, 5.3 and 12.0, respectively.

Conclusion: Due to the high prevalence of STI coinfections, AGW patients should be screened for other STIs.

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References

    1. Bhatia N, Lynde C, Vender R, Bourcier M. Understanding genital warts: epidemiology, pathogenesis, and burden of disease of human papillomavirus. J Cutan Med Surg 2013; 17 (Suppl 2): S47-54.
    1. Desai S, Wetten S, Woodhall SC et al. Genital warts and cost of care in England. Sex Transm Infect 2011; 87: 464-8.
    1. Patel H, Wagner M, Singhal P, Kothari S. Systematic review of the incidence and prevalence of genital warts. BMC Infect Dis 2013; 13: 39.
    1. Yakely AE, Avni-Singer L, Oliveira CR, Niccolai LM. Human papillomavirus vaccination and anogenital warts: A systematic review of impact and effectiveness in the United States. Sex Transm Dis 2018; 46: 213-20.
    1. Flagg EW, Torrone EA. Declines in anogenital warts among age groups most likely to be impacted by human papillomavirus vaccination, United States, 2006-2014. Am J Public Health 2018; 108: 112-9.

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