Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology

Adolfo Ramirez-Zamora¹, James Giordano², Aysegul Gunduz^{3

4}, Jose Alcantara^{3

4}, Jackson N Cagle^{3

4}, Stephanie Cernera^{3

4}, Parker Difuntorum^{3

4}, Robert S Eisinger^{3

4}, Julieth Gomez^{3

4}, Sarah Long^{3

4}, Brandon Parks^{3

4}, Joshua K Wong¹, Shannon Chiu¹, Bhavana Patel¹, Warren M Grill⁵, Harrison C Walker^{6

7}, Simon J Little⁸, Ro'ee Gilron⁹, Gerd Tinkhauser^{10

11}, Wesley Thevathasan^{12

13

14}, Nicholas C Sinclair^{13

14}, Andres M Lozano¹⁵, Thomas Foltynie¹⁶, Alfonso Fasano^{17

18}, Sameer A Sheth¹⁹, Katherine Scangos²⁰, Terence D Sanger²¹, Jonathan Miller²², Audrey C Brumback²³, Priya Rajasethupathy^{24

25}, Cameron McIntyre²⁶, Leslie Schlachter²⁷, Nanthia Suthana²⁸, Cynthia Kubu²⁹, Lauren R Sankary³⁰, Karen Herrera-Ferrá³¹, Steven Goetz³², Binith Cheeran³³, G Karl Steinke³⁴, Christopher Hess¹, Leonardo Almeida¹, Wissam Deeb¹, Kelly D Foote³⁵, Michael S Okun¹

Affiliations

¹ Department of Neurology, Norman Fixel Institute for Neurological Diseases, Program for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, United States.
² Departments of Neurology and Biochemistry, and Neuroethics Studies Program-Pellegrino Center for Clinical Bioethics, Georgetown University Medical Center, Washington, DC, United States.
³ J. Crayton Pruitt Family Department of Biomedical Engineering, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, United States.
⁴ Department of Neurosurgery, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, United States.
⁵ Department of Biomedical Engineering, Duke University, Durham, NC, United States.
⁶ Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States.
⁷ Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States.
⁸ Department of Neurology, University of California, San Francisco, San Francisco, CA, United States.
⁹ Graduate Program in Neuroscience, Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, United States.
¹⁰ Department of Neurology, Bern University Hospital and the University of Bern, Bern, Switzerland.
¹¹ Medical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, United Kingdom.
¹² Department of Neurology, The Royal Melbourne and Austin Hospitals, University of Melbourne, Melbourne, VIC, Australia.
¹³ Medical Bionics Department, University of Melbourne, East Melbourne, VIC, Australia.
¹⁴ Bionics Institute, East Melbourne, VIC, Australia.
¹⁵ Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, ON, Canada.
¹⁶ Institute of Neurology, University College London, London, United Kingdom.
¹⁷ Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, ON, Canada.
¹⁸ Division of Neurology, University of Toronto, Krembil Brain Institute, Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, Canada.
¹⁹ Department of Neurological Surgery, Baylor College of Medicine, Houston, TX, United States.
²⁰ Department of Psychiatry, University of California, San Francisco, San Francisco, CA, United States.
²¹ Department of Biomedical Engineering, Neurology, Biokinesiology, University of Southern California, Los Angeles, CA, United States.
²² Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, United States.
²³ Departments of Neurology and Pediatrics at Dell Medical School and the Center for Learning and Memory, University of Texas at Austin, Austin, TX, United States.
²⁴ Laboratory for Neural Dynamics and Cognition, Rockefeller University, New York, NY, United States.
²⁵ Department of Bioengineering, Stanford University, Stanford, CA, United States.
²⁶ Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
²⁷ Department of Neurosurgery, Mount Sinai Health System, New York, NY, United States.
²⁸ Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
²⁹ Department of Neurology, Cleveland Clinic, Cleveland, OH, United States.
³⁰ Center for Bioethics, Cleveland Clinic, Cleveland, OH, United States.
³¹ Asociación Mexicana de Neuroética, Mexico City, Mexico.
³² Medtronic Neuromodulation, Minneapolis, MN, United States.
³³ Neuromodulation Division, Abbott, Plano, TX, United States.
³⁴ Boston Scientific Neuromodulation, Valencia, CA, United States.
³⁵ Department of Neurosurgery, Norman Fixel Institute for Neurological Diseases, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, United States.

PMID: 32292333
PMCID: PMC7134196
DOI: 10.3389/fnhum.2020.00054

Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology

Adolfo Ramirez-Zamora et al. Front Hum Neurosci. 2020.

. 2020 Mar 27:14:54.

doi: 10.3389/fnhum.2020.00054. eCollection 2020.

Authors

Affiliations

¹ Department of Neurology, Norman Fixel Institute for Neurological Diseases, Program for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, United States.
² Departments of Neurology and Biochemistry, and Neuroethics Studies Program-Pellegrino Center for Clinical Bioethics, Georgetown University Medical Center, Washington, DC, United States.
³ J. Crayton Pruitt Family Department of Biomedical Engineering, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, United States.
⁴ Department of Neurosurgery, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, United States.
⁵ Department of Biomedical Engineering, Duke University, Durham, NC, United States.
⁶ Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States.
⁷ Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States.
⁸ Department of Neurology, University of California, San Francisco, San Francisco, CA, United States.
⁹ Graduate Program in Neuroscience, Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, United States.
¹⁰ Department of Neurology, Bern University Hospital and the University of Bern, Bern, Switzerland.
¹¹ Medical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, United Kingdom.
¹² Department of Neurology, The Royal Melbourne and Austin Hospitals, University of Melbourne, Melbourne, VIC, Australia.
¹³ Medical Bionics Department, University of Melbourne, East Melbourne, VIC, Australia.
¹⁴ Bionics Institute, East Melbourne, VIC, Australia.
¹⁵ Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, ON, Canada.
¹⁶ Institute of Neurology, University College London, London, United Kingdom.
¹⁷ Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, ON, Canada.
¹⁸ Division of Neurology, University of Toronto, Krembil Brain Institute, Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, Canada.
¹⁹ Department of Neurological Surgery, Baylor College of Medicine, Houston, TX, United States.
²⁰ Department of Psychiatry, University of California, San Francisco, San Francisco, CA, United States.
²¹ Department of Biomedical Engineering, Neurology, Biokinesiology, University of Southern California, Los Angeles, CA, United States.
²² Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, United States.
²³ Departments of Neurology and Pediatrics at Dell Medical School and the Center for Learning and Memory, University of Texas at Austin, Austin, TX, United States.
²⁴ Laboratory for Neural Dynamics and Cognition, Rockefeller University, New York, NY, United States.
²⁵ Department of Bioengineering, Stanford University, Stanford, CA, United States.
²⁶ Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
²⁷ Department of Neurosurgery, Mount Sinai Health System, New York, NY, United States.
²⁸ Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
²⁹ Department of Neurology, Cleveland Clinic, Cleveland, OH, United States.
³⁰ Center for Bioethics, Cleveland Clinic, Cleveland, OH, United States.
³¹ Asociación Mexicana de Neuroética, Mexico City, Mexico.
³² Medtronic Neuromodulation, Minneapolis, MN, United States.
³³ Neuromodulation Division, Abbott, Plano, TX, United States.
³⁴ Boston Scientific Neuromodulation, Valencia, CA, United States.
³⁵ Department of Neurosurgery, Norman Fixel Institute for Neurological Diseases, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, United States.

PMID: 32292333
PMCID: PMC7134196
DOI: 10.3389/fnhum.2020.00054

Abstract

The Seventh Annual Deep Brain Stimulation (DBS) Think Tank held on September 8th of 2019 addressed the most current: (1) use and utility of complex neurophysiological signals for development of adaptive neurostimulation to improve clinical outcomes; (2) Advancements in recent neuromodulation techniques to treat neuropsychiatric disorders; (3) New developments in optogenetics and DBS; (4) The use of augmented Virtual reality (VR) and neuromodulation; (5) commercially available technologies; and (6) ethical issues arising in and from research and use of DBS. These advances serve as both "markers of progress" and challenges and opportunities for ongoing address, engagement, and deliberation as we move to improve the functional capabilities and translational value of DBS. It is in this light that these proceedings are presented to inform the field and initiate ongoing discourse. As consistent with the intent, and spirit of this, and prior DBS Think Tanks, the overarching goal is to continue to develop multidisciplinary collaborations to rapidly advance the field and ultimately improve patient outcomes.

Keywords: Parkinson’s disease; deep brain stimulation; depression; local field potentials; neuroethics; optogenetics; stereoelectroencephalography; tremor.

Copyright © 2020 Ramirez-Zamora, Giordano, Gunduz, Alcantara, Cagle, Cernera, Difuntorum, Eisinger, Gomez, Long, Parks, Wong, Chiu, Patel, Grill, Walker, Little, Gilron, Tinkhauser, Thevathasan, Sinclair, Lozano, Foltynie, Fasano, Sheth, Scangos, Sanger, Miller, Brumback, Rajasethupathy, McIntyre, Schlachter, Suthana, Kubu, Sankary, Herrera-Ferrá, Goetz, Cheeran, Steinke, Hess, Almeida, Deeb, Foote and Okun.

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References

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Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology

Affiliations

Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology

Authors

Affiliations

Abstract

References

Grants and funding

LinkOut - more resources

Full Text Sources

Research Materials