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Review
. 2020 Apr 4:35:100673.
doi: 10.1016/j.nmni.2020.100673. eCollection 2020 May.

Mutated COVID -19 may foretell a great risk for mankind in the future

A A Dawood  1
Affiliations
Review

Mutated COVID -19 may foretell a great risk for mankind in the future

A A Dawood. New Microbes New Infect. .

Abstract

Coronavirus disease 2019 SARS-CoV-2 (COVID-19) is a zoonotic virus causing a variety of severe respiratory diseases. SARS-CoV-2 is closest to SARS-CoV and MERS-CoV in structure. The high prevalence of COVID-19 is a result of a lack of symptoms at onset. Our study aimed to present an overview of the virus in terms of structure, epidemiology, symptoms, treatment and prevention. Whole genome sequences and some viral proteins were investigated to determine gaps and changes in alternation of nucleotides and amino acid sequences. We evaluate 11 complete genome sequences of different coronaviruses using BAST and MAFFT software. We also selected seven types of structural proteins. We conclude that COVID-19 might produce new mutations, specifically in glycoproteins, so caution and complete preparation by health authorities is required.

Keywords: COVID-19; Middle-East respiratory syndrome; outbreaks; severe acute respiratory syndrome; zoonotic.

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Figures

Fig. 1
Fig. 1
Final alignment of four complete genomes.
Fig. 2
Fig. 2
MAFFT considers similarities in forward strands (red) only, but ignores similarities in reverse strands (blue), Plot 1/2: alignment MT066175.1 + MT039873.1 99.7%, plot 1/3: MT066175.1+ MN997409.1 99.7%, plot 1/4: MT066175.1 + MN996532.1 89%, plot 1/5: MT066175.1 + EU371564.1 82.4%, plot 1/6: MT066175.1 + KY938558.1 = 68%, plot 1/7: MT066175.1 + MN985325.1 95%.
Fig. 3
Fig. 3
100% similarity between open-reading frame 10 of QIK50446.1 and YP_009725255.1.
Fig. 4
Fig. 4
Alignment of QIK50445.1, QIC50514.1, AAS01074.1 and QHA24694.1.
Fig. 5
Fig. 5
Crystal structure of NP COVID-19 (6VYO) from RCSB PDB.
Fig. 6
Fig. 6
Alignment of QIK50443.1, QHR63305.1, AFR58706.1 and AAX16199.1.
Fig. 7
Fig. 7
Alignment of QIK50444.1, QHN73801.1, ACU31050.1 and ADE34775.1.
Fig. 8
Fig. 8
Alignment of QIK50442.1, QIG55989.1, AHX37562.1 and AGT21083.1.
Fig. 9
Fig. 9
Alignment of QIK50441.1, QIG55988.1, APO40582.1 and YP_001039974.1.
Fig. 10
Fig. 10
Alignment of QIK50440.1, QHZ00381.1, 5X29_A and ASL68947.1.
See this image and copyright information in PMC

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