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Review
. 2020 Jan-Mar;64(1):3-7.

Eye involvement in ANCA positive vasculitis

Sorin Simion Macarie  1 , Alexandra Kadar  2
Affiliations
Review

Eye involvement in ANCA positive vasculitis

Sorin Simion Macarie et al. Rom J Ophthalmol. 2020 Jan-Mar.

Abstract

Vasculitis is a heterogeneous group of diseases that implies the presence of necrosis and inflammation in the walls of blood vessels. The mechanisms involved are the following: immune complexes, endothelial cell antibodies, and anti-lysosomal antibodies. The immune reactions can be triggered by these mechanisms: immune complexes, endothelial cell antibodies, and anti-lysosomal antibodies. Antineutrophil cytoplasmic antibodies (ANCA) have an essential role in the following so-called ANCA+ vasculitis. Regarding this issue, we proposed to present the various aspects of ocular involvement in the ANCA+ vasculitis.

Keywords: ANCA positive vasculitis; blood vessels; granulomatosis; inflammation; necrosis; polyangiitis.

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Figures

Fig. 1
Fig. 1
Definitions of vasculitis adopted by the 2012 International Chapel Hill Consensus Conference on the Nomenclature of Vasculitis for ANCA+. Source: J.C. Jennette, R.J. Falk, P.A. Bacon, N. Basu, M.C. Cid, F. Ferrario, L.F. Flores-Suarez et al. Arthritis & Rheumatism. An Official Journal of the American College of Rheumatology. Vol. 65, No. 1, January 2013, pp 1-11. DOI 10.1002/art 37715. 2013, American College of Rheumatology.
Fig. 2
Fig. 2
Ocular involvement in granulomatosis with poliangiitis
Fig. 3
Fig. 3
Retinal involvement in granulomatosis with poliangiitis
See this image and copyright information in PMC

References

    1. Sablé-Fourtassou R, Cohen P, Mahr A, Pagnoux C. Antineutrophil Cytoplasmic Antibodies and the Churg-Strauss Syndrome. Ann Intern Med. 2005;143(9) - PubMed
    1. Boomsma MM, Stegeman CA, van der Leij MJ, Oost W, Hermans J, Kallenberg CG, et al. Prediction of relapses in Wegener’s granulomatosis by measurement of antineutrophil cytoplasmic antibody levels: a prospective study. Arthritis Rheum. 2000;43(9):2025–2033. - PubMed
    1. Kemna MJ, Damoiseaux J, Austen J, Winkens B, Peters J, van Paassen P, et al. ANCA as a predictor of relapse: useful in patients with renal involvement but not in patients with nonrenal disease. J Am Soc Nephrol. 2015 Mar;26(3):537–542. - PMC - PubMed
    1. Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013 Jan;65(1):1–11. - PubMed
    1. Finkielman JD, Merkel PA, Schroeder D, Hoffman GS, Spiera R, St Clair EW, et al. Antiproteinase 3 antineutrophil cytoplasmic antibodies and disease activity in Wegener granulomatosis. Ann Intern Med. 2007 Nov 6; - PubMed

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