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Editorial
. 2020 Mar 27;5(5):563-565.
doi: 10.1016/j.ekir.2020.03.024. eCollection 2020 May.

COVID-19 and the Renin-Angiotensin System

Line Malha  1 , Franco B Mueller  1 , Mark S Pecker  1 , Samuel J Mann  1 , Phyllis August  1 , Peter U Feig  1
Affiliations
Editorial

COVID-19 and the Renin-Angiotensin System

Line Malha et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Renin-angiotensin ACE2 pathway. ACE, angiotensin-converting enzyme; ACE2, angiotensin-converting enzyme 2; AngI, angiotensin I; AngII, angiotensin II; AngIII, angiotensin III; ATR1, angiotensin receptor 1; ATR2, angiotensin receptor 2; MAS1, proto-oncogene, G protein–coupled receptor.
See this image and copyright information in PMC

References

    1. Gurwitz D. Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics [e-pub ahead of print]. Drug Dev Res.. Accessed March 13, 2020. - DOI - PMC - PubMed
    1. Meng Y., Yu C.H., Li W. Angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis protects against lung fibrosis by inhibiting the MAPK/NF-kappaB pathway. Am J Respir Cell Mol Biol. 2014;50:723–736. - PubMed
    1. Koka V., Huang X.R., Chung A.C. Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway. Am J Pathol. 2008;172:1174–1183. - PMC - PubMed
    1. Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study [e-pub ahead of print]. Lancet Respir Med.. - DOI - PMC - PubMed
    1. Li W., Moore M.J., Vasilieva N. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003;426:450–454. - PMC - PubMed

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