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Case Reports
. 2020 Apr 9;5(6):935-939.
doi: 10.1016/j.ekir.2020.04.002. eCollection 2020 Jun.

Collapsing Glomerulopathy in a Patient With COVID-19

Christopher P Larsen  1 , Thomas D Bourne  1 , Jon D Wilson  1 , Osaid Saqqa  2 , Moh'd A Sharshir  2
Affiliations
Case Reports

Collapsing Glomerulopathy in a Patient With COVID-19

Christopher P Larsen et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Renal biopsy findings. (a) Tubular epithelium with reactive nuclei including focal mitotic figures (arrow) as well as cytoplasmic simplification and denudation of brush borders (hematoxylin-eosin; original magnification ×400). (b) Glomerulus with tuft collapse and overlying epithelial hypertrophy and hyperplasia (Jones methenamine silver; original magnification ×400). (c) Ultrastructural examination reveals extensive foot process effacement (original magnification ×6000). (d) Tubuloreticular inclusions (arrow) within a glomerular endothelial cell (original magnification ×30,000).
Figure 2
Figure 2
In situ hybridization for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (a) Tissue quality was evaluated by performing RNAscope analysis for mRNA of the housekeeping gene peptidylprolyl isomerase B (PPIB). Positive cytoplasmic staining confirms adequate quality. Signal was detected using 3,3′-diaminobenzidine (DAB) (brown) chromogen. (periodic acid–Schiff counter stain; original magnification ×400). (b) RNAscope using probes directed against SARS-CoV-2 shows absence of signal in the patient's kidney parenchyma (periodic acid–Schiff counter stain; original magnification ×400).
See this image and copyright information in PMC

Comment in

  • Six Years of KI Reports: Milestones Behind and Ahead.
    McLean R, Mohan S, Radhakrishnan J. McLean R, et al. Kidney Int Rep. 2021 Dec 6;7(1):1-2. doi: 10.1016/j.ekir.2021.11.030. eCollection 2022 Jan. Kidney Int Rep. 2021. PMID: 35005305 Free PMC article. No abstract available.

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