Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Jul 15;2(9):1315-1320.
doi: 10.1016/j.jaccas.2020.04.001. Epub 2020 Apr 8.

The Imperfect Cytokine Storm: Severe COVID-19 With ARDS in a Patient on Durable LVAD Support

Affiliations
Case Reports

The Imperfect Cytokine Storm: Severe COVID-19 With ARDS in a Patient on Durable LVAD Support

Vinh Q Chau et al. JACC Case Rep. .

Abstract

As health systems worldwide grapple with the coronavirus disease-2019 (COVID-19) pandemic, patients with durable LVAD support represent a unique population at risk for the disease. This paper outlines the case of such a patient who developed COVID-19 complicated by a "cytokine storm" with severe acute respiratory distress syndrome and myocardial injury and describes the challenges that arose during management.

Keywords: ARDS; ARDS, acute respiratory distress syndrome; COVID-19; COVID-19, coronavirus disease-2019; LVAD; LVAD, left ventricular assist device; MODS, multiorgan dysfunction syndrome; PEA, pulseless electrical activity; RV, right ventricle; SARS-CoV-2, severe acute respiratory syndrome-coronavirus-2; cytokine storm.

PubMed Disclaimer

Figures

None
Graphical abstract
Figure 1
Figure 1
Clinical Course Timeline of Severe COVID-19 Infection in This Patient on LVAD Support
Central Illustration
Central Illustration
Clinical Guidance and Considerations at Mount Sinai for Managing COVID-19 in Patients on LVAD Support

Comment in

References

    1. ARDSnet. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The acute respiratory distress syndrome network. N Engl J Med. 2000;342:1301–1308. - PubMed
    1. New York State Department of Health. NYSDOH (New York State Department of Health) COVID-19 Tracker. Persons Tested Positive by County. Albany, NY: NYSDOH Available at: https://coronavirus.health.ny.gov/county-county-breakdown-positive-cases. Accessed April 9, 2020.
    1. Tisoncik J.R., Korth M.J., Simmon C.P. Into the eye of the cytokine storm. Microbiol Mol Biol Rev. 2012;76:16–32. - PMC - PubMed
    1. Clerkin K.J., Fried J.A., Raikhelkar J. Coronavirus disease 2019 (COVID-19) and cardiovascular disease. Circulation. 2020;141:1648–1655. - PubMed
    1. Siddiqi H.K., Mehra M.R. COVID-19 Illness in native and immunosuppressed states: A clinical therapeutic staging proposal. J Heart Lung Transpl. 2020;39:405–407. - PMC - PubMed

Publication types