Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Jun;18(6):1511-1513.
doi: 10.1111/jth.14818. Epub 2020 Apr 15.

Pulmonary thrombosis in 2019-nCoV pneumonia?

Francesco Marongiu  1 , Elvira Grandone  2   3 , Doris Barcellona  1
Affiliations
Comment

Pulmonary thrombosis in 2019-nCoV pneumonia?

Francesco Marongiu et al. J Thromb Haemost. 2020 Jun.
No abstract available

Keywords: 2019 nCoV; ARDS; DIC; heparin; pulmonary thrombosis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A drawing to illustrate a possible mechanism inducing pulmonary thrombosis. After nCoV infection monocytes and released cytokines can provoke interstitial inflammation, endothelial damage, and blood coagulation activation. Tissue factor is crucial in that it can be either exposed by monocytes, damaged endothelial cells or activated by the cytokines’ burden. The final result may be thrombin production and consequent alveolar and capillary thrombosis. C, cytokines; DEC, damaged endothelial cells; M, monocyte; nCoV, novel coronavirus; P, pneumocyte; TF, tissue factor; Th, thrombin
See this image and copyright information in PMC

Comment in

Comment on

References

    1. Tang N., Li D., Wang X., Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844–847. - PMC - PubMed
    1. Marongiu F., Mameli A., Grandone E., Barcellona D. Pulmonary thrombosis: a clinical pathological entity distinct from pulmonary embolism? Semin Thromb Hemost. 2019;45:778–783. - PubMed
    1. Rogers K.J., Maury W. The role of mononuclear phagocytes in Ebola virus infection. J Leukoc Biol. 2018;104:717–727. - PubMed
    1. Müller N.F., Schampera M., Jahn G., Malek N.P., Berg C.P., Hamprecht K. Case report: severe cytomegalovirus primary infection in an immunocompetent adult with disseminated intravascular coagulation treated with valganciclovir. BMC Infect Dis. 2016;16:19. - PMC - PubMed
    1. Levi M. Pathogenesis and diagnosis of disseminated intravascular coagulation. Int J Lab Hematol. 2018;40(Suppl 1):15–20. - PubMed