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Meta-Analysis
. 2020 Apr 15;19(1):33.
doi: 10.1186/s12937-020-00548-6.

Effects of resistant starch interventions on circulating inflammatory biomarkers: a systematic review and meta-analysis of randomized controlled trials

Mahsa Vahdat  1   2 , Seyed Ahmad Hosseini  1   2 , Golsa Khalatbari Mohseni  1   2 , Javad Heshmati  3 , Mehran Rahimlou  4   5
Affiliations
Meta-Analysis

Effects of resistant starch interventions on circulating inflammatory biomarkers: a systematic review and meta-analysis of randomized controlled trials

Mahsa Vahdat et al. Nutr J. .

Abstract

Purpose: This study aimed to summarize earlier studies on the effects of RS consumption on the serum levels of inflammatory biomarkers.

Methods: A comprehensive search was done in the electronic databases that published from 1988 up to May 2019. Two reviewers independently performed screening, data extraction, and risk-of-bias assessment. We used from the effect size, as estimated by the mean difference to perform the fixed method meta-analysis.

Results: Overall, 13 studies with 14 effect sizes met the inclusion criteria and were included in the final analysis. Sample size of these studies ranged from 15 to 75 and intervention duration ranged from 4 to 14 weeks. Meta-analysis revealed that higher consumption of resistant starch caused a significant reduction in the interleukin 6 (weighted mean difference = - 1.11 pg/mL; 95% CI: - 1.72, - 0.5 pg/mL; P = < 0.001) and tumor necrosis factor alpha (weighted mean difference = - 2.19 pg/mL; 95% CI: - 3.49, - 0.9 pg/mL; P = 0.001) levels. However, no significant changes were found in C-reactive protein concentration (weighted mean difference = - 0.21 mg/L; 95% CI: - 1.06, 0.63 mg/L; P = 0.61). Moreover, the changes in interleukin 6 concentration was dependent on study quality and intervention duration.

Conclusion: The current meta-analysis indicated that RS intake can improve some inflammatory biomarkers. More research, with a large sample sizes and accurate design is recommended.

Keywords: CRP; Inflammation; Meta-analysis; Resistant starch; TNF-α, IL-6.

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Conflict of interest statement

All authors declare that they have no conflict of interest and all authors read and approved the final manuscript. For this type of study formal consent is not required.

Figures

Fig. 1
Fig. 1
Flow diagram of literature search according to the PRISMA statement
Fig. 2
Fig. 2
Forest plot summarizing the association between intake resistant starches on circulating CRP concentrations
Fig. 3
Fig. 3
Forest plot summarizing the association between intake resistant starches on circulating TNF-α concentrations
Fig. 4
Fig. 4
Forest plot summarizing the association between intake resistant starches on circulating IL-6 concentrations
Fig. 5
Fig. 5
a Funnel plots detailing publication bias in the selected studies of the relation between intakes of resistant starches products and circulating IL-6. b. Funnel plots detailing publication bias in the selected studies of the relation between intakes of resistant starches products and circulating CRP. c. Funnel plots detailing publication bias in the selected studies of the relation between intakes of resistant starches products and circulating IL-6
See this image and copyright information in PMC

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