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Review
. 2020 Apr 15;22(1):78.
doi: 10.1186/s13075-020-02180-5.

Cognitive dysfunction in autoimmune rheumatic diseases

Csaba Oláh  1 , Noa Schwartz  2 , Christopher Denton  3 , Zsófia Kardos  4 , Chaim Putterman  2   5   6   7 , Zoltán Szekanecz  8
Affiliations
Review

Cognitive dysfunction in autoimmune rheumatic diseases

Csaba Oláh et al. Arthritis Res Ther. .

Abstract

For people with chronic autoimmune rheumatic diseases (AIRD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or systemic sclerosis (SSc), normal cognitive functions are essential for performing daily activities. These diseases may be associated with cognitive dysfunction (CD). In RA, CD has been associated with age, lower education and disease duration and activity. Great advances have been achieved in neuropsychiatric SLE in the identification of pathogenic pathways, assessment and possible treatment strategies. SSc rarely exerts direct effects on the brain and cognitive function. However, the psychological burden that includes depression, anxiety and social impact may be high. AIRD patients with sustained disease activity, organ damage or lower education should be evaluated for CD. The control of systemic inflammation together with tailored behavioural cognitive therapies may benefit these patients.

Keywords: Cognitive dysfunction; Cognitive function; Neuropsychiatric lupus; Rheumatoid arthritis; Systemic lupus erythematosus; Systemic sclerosis.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Meade T, Manolios N, Cumming SR, Conaghan PG, Katz P. Cognitive impairment in rheumatoid arthritis: a systematic review. Arthritis Care Res (Hoboken) 2018;70(1):39–52. doi: 10.1002/acr.23243. - DOI - PubMed
    1. Olah C, Kardos Z, Andrejkovics M, Szarka E, Hodosi K, Domjan A, Sepsi M, Sas A, Kostyal L, Fazekas K, et al. Assessment of cognitive function in female rheumatoid arthritis patients: associations with cerebrovascular pathology, depression and anxiety. Rheumatol Int. 2020;40(4):529–40. - PubMed
    1. Rayes HA, Tani C, Kwan A, Marzouk S, Colosimo K, Medina-Rosas J, Mustafa A, Su J, Lambiris P, Mosca M, et al. What is the prevalence of cognitive impairment in lupus and which instruments are used to measure it? A systematic review and meta-analysis. Semin Arthritis Rheum. 2018;48(2):240–255. doi: 10.1016/j.semarthrit.2018.02.007. - DOI - PubMed
    1. Giuliodori G, Fraticelli P, Bartolini M, Cagnetti C, Baruffaldi R, Rocchi MB, Provinciali L, Gabrielli A, Silvestrini M. Cognitive and cerebral hemodynamic impairment in scleroderma patients. Eur J Neurol. 2009;16(12):1285–1290. doi: 10.1111/j.1468-1331.2009.02714.x. - DOI - PubMed
    1. Joaquim AF, Appenzeller S. Neuropsychiatric manifestations in rheumatoid arthritis. Autoimmun Rev. 2015;14(12):1116–1122. doi: 10.1016/j.autrev.2015.07.015. - DOI - PubMed

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