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. 2020 May 14;41(19):1804-1806.
doi: 10.1093/eurheartj/ehaa311.

Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts

Luka Nicin  1 , Wesley Tyler Abplanalp  1 , Hannah Mellentin  1 , Badder Kattih  2 , Lukas Tombor  1 , David John  1 , Jan D Schmitto  3 , Jörg Heineke  4   5 , Fabian Emrich  6 , Mani Arsalan  6 , Tomas Holubec  6 , Thomas Walther  6   7 , Andreas M Zeiher  2   7   8 , Stefanie Dimmeler  1   7   8
Affiliations

Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts

Luka Nicin et al. Eur Heart J. .
No abstract available

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Figures

Figure 1
Figure 1
Regulation of ACE and ACE2 expression in human hearts. (A) Baseline characteristics of patients. (B and C) Single nuclei RNA sequencing of left ventricular cardiac tissue of two samples from a healthy donor and seven patients with heart disease. Uniform manifold approximation and projection (UMAP) plot. CM, cardiomyocytes; EC, endothelial cell; FB, fibroblast; PC, pericytes; SMC, smooth muscle cells; ECFB, endothelial and fibroblast marker-expressing cluster; NLC, neuronal like cells; Unk, unknown (B); and representative marker gene expression in each cluster (C) are shown. (D) Representative cardiac (troponin T2, TNNT2), endothelial (VE-cadherin, CDH5), fibroblast (PDGFRA), mural cell (PDGFRB), and leucocyte (CD45, PTPRC) markers and expression of ACE2 are shown in UMI (unique molecular identifier) counts per cell. (E) Expression of ACE2 in clusters annotated in (B). (F) Immunostaining against ACE2 (ab15348, Abcam) in healthy human hearts and in patients with AS (representative images of n = 7 patients with AS are shown). (G) Expression of ACE in cardiomyocytes. (H and I) Expression of ACE2 and ACE/ACE2 ratios in cardiomyocytes of healthy donor patients treated with ARBs (n = 2) and ACE inhibitors (n = 4). Data are shown as mean ± SEM. Statistical analysis was performed using the unpaired, two-sided Student’s t-test. For comparisons of >2 groups, multiple-group ANOVA with a post-hoc Tukey’s test was used.
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