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. 2020 Apr 6:75:e1507.
doi: 10.6061/clinics/2020/e1507. eCollection 2020.

Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil

Luiz Paulo Kowalski  1 , Max Moura de Oliveira  2 , Rossana Veronica Mendoza Lopez  2   3 , Diego Rodrigues Mendonça E Silva  2 , Mauro Kazuo Ikeda  1 , Maria Paula Curado  2
Affiliations

Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil

Luiz Paulo Kowalski et al. Clinics (Sao Paulo). .

Abstract

Objective: We aimed to estimate the overall survival (OS) and conditional survival (CS) in patients diagnosed with oral and oropharyngeal squamous cell carcinoma (SCC) and to determine their survival trends.

Methods: The study included all consecutive patients treated at the A.C. Camargo Cancer Center for oral or oropharyngeal SCC between 2001 and 2012. Data were obtained from the Hospital Cancer Registry. OS and CS were analyzed using the Kaplan-Meier method to evaluate the probability of survival with Cox predictor models.

Results: Data of 505 oral and 380 oropharyngeal SCC patients obtained in 2001-2006 and 2007-2012 were analyzed. Most of the oral SCC (59%) and oropharyngeal SCC (90%) patients had stages III-IV SCC. The 5-year OS for patients with oral SCC was 51.7%, with no significant difference between the first and second periods. The CS rates in 2007-2012 were 65% after the first year and 86% up to the fifth year. For oropharyngeal SCC, the 5-year OS rate was 45.0% in the first period. The survival rate increased to 49.1% from 2007 to 2012, with a reduction in the risk of death (HR=0.69;0.52-09.2). The CS estimates from 2007 to 2012 were 59% after the first year and 75% up to the fifth year.

Conclusion: Survival across the two time periods remained stable for oral SCC but showed a significant increase for oropharyngeal SCC, possibly because of improvements in the patients' response to radiotherapy, such as intensity-modulated radiation therapy, and the use of more accurate diagnostic imaging approaches.

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Conflict of interest statement

No potential conflict of interest was reported.

Figures

Figure 1
Figure 1. Overall survival of patients with oral and oropharyngeal squamous cell carcinoma treated at the A. C. Camargo Cancer Center, Hospital Cancer Registry, 2001–2012, by period of diagnosis.
Figure 2
Figure 2. Five-year probability conditional survival of patients with oral and oropharyngeal squamous cell carcinoma treated at the A. C. Camargo Cancer Center, Hospital Cancer Registry 2001–2012, according period of diagnosis. Oro, oropharynx; OC, oral cavity.
See this image and copyright information in PMC

References

    1. Ferlay J, Ervik M, Lam F. Lyon, France:: International Agency for Research on Cancer; Global Cancer Observatory: Cancer Today. Available from: https://gco.iarc.fr/today. [Accessed November 30th, 2019]
    1. Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) Estimativa 2018 - Incidência de câncer no Brasil. Rio de Janeiro: Inca; 2017;130p; Available from: http://www.inca.gov.br/estimativa/2018/estimativa-2018.pdf.
    1. Chin D, Boyle GM, Porceddu S, Theile DR, Parsons PG, Coman WB. Head and neck cancer: past, present and future. Expert Rev Anticancer Ther. 2006;6((7)):1111–8. doi: 10.1586/14737140.6.7.1111. - DOI - PubMed
    1. Pulte D, Brenner H. Changes in survival in head and neck cancers in the late 20th and early 21st century: a period analysis. Oncologist. 2010;15((9)):994–1001. doi: 10.1634/theoncologist.2009-0289. - DOI - PMC - PubMed
    1. Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst. 2000;92((9)):709–20. doi: 10.1093/jnci/92.9.709. - DOI - PubMed