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. 2020 Apr 13;9(4):1114.
doi: 10.3390/jcm9041114.

Clinical Characteristics and Associated Risk Factors of Prediabetes in the Southwestern Region of Korea from 2010-2019

Mi-Ra Oh  1 , Su-Jin Jung  1 , Eun-Ju Bae  2 , Byung-Hyun Park  3 , Soo-Wan Chae  1
Affiliations

Clinical Characteristics and Associated Risk Factors of Prediabetes in the Southwestern Region of Korea from 2010-2019

Mi-Ra Oh et al. J Clin Med. .

Abstract

This study investigated the clinical characteristics and associated risk factors of prediabetes in the southwestern region of Korea. A total of 323 subjects from 13 prediabetes studies were included in the data analysis. Subjects with prediabetes were divided into the following subtypes: (1) normal glucose tolerance (NGT) with HbA1c 5.7%-6.4%; (2) isolated impaired fasting glucose (I-IFG); (3) isolated impaired glucose tolerance (I-IGT); and (4) combined I-IFG and I-IGT (C-IFG/IGT). Clinical and biochemical variables were compared among subtypes, and multivariate logistic regression analysis was used to identify risk factors for prediabetes subtypes. The overall proportion of subjects with NGT, I-IFG, I-IGT and C-IFG/IGT was 8.4%, 20.7%, 33.1% and 37.8%, respectively. In men, C-IFG/IGT was the most common subtype, while in women, I-IGT was the most common. The parameters related to dysglycemia, atherosclerosis and liver dysfunction were higher in subjects in the C-IFG/IGT subtype than in other subtypes. Multiple linear regression analysis revealed independent risk factors for increased FPG, 2h-PPG and HbA1c levels. This study identified the clinical features and independent risk factors for prediabetes subtypes.

Keywords: combined I-IFG and I-IGT; isolated impaired fasting glucose (I-IFG); isolated impaired glucose tolerance (I-IGT); prediabetes; risk factor.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of data collection.
Figure 2
Figure 2
Correlation among (A) FPG, (B) 2h-PPG and HbA1c, and (C) FPG and 2h-PPG.
Figure 3
Figure 3
Logistic regression between (A) NGT vs .other prediabetes groups, (B) I-IFG vs. other prediabetes groups, (C) I-IGT vs. other prediabetes groups, and (D) C-IFG/IGT vs. other prediabetes groups.
See this image and copyright information in PMC

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