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Review
. 2020 Apr 14;17(8):2690.
doi: 10.3390/ijerph17082690.

Coronavirus Diseases (COVID-19) Current Status and Future Perspectives: A Narrative Review

Affiliations
Review

Coronavirus Diseases (COVID-19) Current Status and Future Perspectives: A Narrative Review

Francesco Di Gennaro et al. Int J Environ Res Public Health. .

Abstract

At the end of 2019 a novel virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing severe acute respiratory syndrome expanded globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus a global pandemic. We performed a narrative review to describe existing literature with regard to Corona Virus Disease 2019 (COVID-19) epidemiology, pathophysiology, diagnosis, management and future perspective. MEDLINE, EMBASE and Scopus databases were searched for relevant articles. Although only when the pandemic ends it will be possible to assess the full health, social and economic impact of this global disaster, this review represents a picture of the current state of the art. In particular, we focus on public health impact, pathophysiology and clinical manifestations, diagnosis, case management, emergency response and preparedness.

Keywords: COVID-19; coronavirus; emergency; pandemic; pathogenesis; preparedness.

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Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Lu H., Stratton C.W., Tang Y.W. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. J. Med. Virol. 2020;92:401–402. doi: 10.1002/jmv.25678. - DOI - PMC - PubMed
    1. Huang C., Wang Y., Li Z., Ren L., Zhao J., Hu Y., Zhang L., Fan G., Xu J., Gu X., et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. doi: 10.1016/S0140-6736(20)30183-5. - DOI - PMC - PubMed
    1. World Health Organization Director-General’s Opening Remarks at the Media Briefing on COVID-19–11 March 2020. [(accessed on 11 March 2020)]; Available online: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-re....
    1. Perlman S., Netland J. Coronaviruses post-SARS: Update on replication and pathogenesis. Nat. Rev. Microbiol. 2009;7:439–450. doi: 10.1038/nrmicro2147. - DOI - PMC - PubMed
    1. Lu R., Zhao X., Li J., Niu P., Yang B., Wu H., Wang W., Song H., Huang B., Zhu N., et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet. 2020;395:565–574. doi: 10.1016/S0140-6736(20)30251-8. - DOI - PMC - PubMed

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