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Comment
. 2020 Apr 13;5(1):48.
doi: 10.1038/s41392-020-0125-y.

Human herpesvirus 4 and adaptive immunity in Alzheimer's disease

Jian-Sheng Kang  1 , Pei-Pei Liu  2
Affiliations
Comment

Human herpesvirus 4 and adaptive immunity in Alzheimer's disease

Jian-Sheng Kang et al. Signal Transduct Target Ther. .
No abstract available

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Figures

Fig. 1
Fig. 1
Four cohorts demonstrated the proinflammatory and cytotoxic functions of CD8+ TEMRA cells stimulated by EBV/HHV-4. The predicted AD prevalence among individuals with zero, one or two copies of the APOE ε4 allele was also shown for the potential association between APOE ε4 and HHV. APOE ε4 can facilitate the entry of HHV into the brain. Fonts highlighted in red represent harmful factors. IFN-γ and TNF secreted by CD8+ TEMRA cells are proinflammatory factors, and NKG7, GZMA, and B2M released by CD8+ TEMRA cells are cytotoxic or pro-aging factors
See this image and copyright information in PMC

Comment on

  • Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease.
    Gate D, Saligrama N, Leventhal O, Yang AC, Unger MS, Middeldorp J, Chen K, Lehallier B, Channappa D, De Los Santos MB, McBride A, Pluvinage J, Elahi F, Tam GK, Kim Y, Greicius M, Wagner AD, Aigner L, Galasko DR, Davis MM, Wyss-Coray T. Gate D, et al. Nature. 2020 Jan;577(7790):399-404. doi: 10.1038/s41586-019-1895-7. Epub 2020 Jan 8. Nature. 2020. PMID: 31915375 Free PMC article.

References

    1. Gate, D. et al. Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease. Nature577, 399–404 (2020). - PMC - PubMed
    1. Smith, J. S. & Robinson, N. J. Age-Specific Prevalence of Infection with Herpes Simplex Virus Types 2 and 1: A Global Review. J. Infect. Dis.186, S3–S28 (2002). - PubMed
    1. Kutok, J. L. & Wang, F. Spectrum of Epstein-Barr Virus–Associated Diseases. Annu. Rev. Pathol. Mech. Dis.1, 375–404 (2006). - PubMed
    1. Carbone, I. et al. Herpes virus in Alzheimer’s disease: relation to progression of the disease. Neurobiol. Aging35, 122–129 (2014). - PubMed
    1. Breitner, J. C. et al. APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study. Neurology53, 321–331 (1999). - PubMed

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