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Comment
. 2020 Apr 1;5(1):37.
doi: 10.1038/s41392-020-0145-7.

NLRP3 inflammasome as a novel therapeutic target for Alzheimer's disease

Yun Zhang  1 , Zhifang Dong  2 , Weihong Song  3   4
Affiliations
Comment

NLRP3 inflammasome as a novel therapeutic target for Alzheimer's disease

Yun Zhang et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Activation of the NLRP3 inflammasome increases tau hyperphosphorylation. Tau monomers and oligomers stimulate NLRP3 activation. The loss of NLRP3 inflammasome function reduces tau pathology. Fibrillar Aβ induces tau pathology in an NLRP3-dependent manner, which further supports the amyloid cascade hypothesis
See this image and copyright information in PMC

Comment on

  • NLRP3 inflammasome activation drives tau pathology.
    Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock DT, Blum D, Latz E, Buée L, Heneka MT. Ising C, et al. Nature. 2019 Nov;575(7784):669-673. doi: 10.1038/s41586-019-1769-z. Epub 2019 Nov 20. Nature. 2019. PMID: 31748742 Free PMC article.

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