Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jun;99(6):1205-1208.
doi: 10.1007/s00277-020-04019-0. Epub 2020 Apr 15.

Mechanism of thrombocytopenia in COVID-19 patients

Panyang Xu  1 , Qi Zhou  2 , Jiancheng Xu  3
Affiliations
Review

Mechanism of thrombocytopenia in COVID-19 patients

Panyang Xu et al. Ann Hematol. 2020 Jun.

Abstract

Since December 2019, a novel coronavirus has spread throughout China and across the world, causing a continuous increase in confirmed cases within a short period of time. Some studies reported cases of thrombocytopenia, but hardly any studies mentioned how the virus causes thrombocytopenia. We propose several mechanisms by which coronavirus disease 2019 causes thrombocytopenia to better understand this disease and provide more clinical treatment options.

Keywords: Coronavirus disease 2019; Platelet; Severe acute respiratory syndrome coronavirus 2; Thrombocytopenia.

PubMed Disclaimer

Conflict of interest statement

The authors declare there they have no conflict of interest.

Figures

Fig. 1
Fig. 1
The possible mechanisms of thrombocytopenia in COVID-19 patients. SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; COVID-19, coronavirus disease 2019; MK, megakaryocyte;↑, means an increase in a substance; ↓, means a decrease in a substance
See this image and copyright information in PMC

Comment in

  • Thrombocytopenia in COVID-19: pathophysiology matters.
    Gavriilaki E, Sakellari I, Gavriilaki M, Anagnostopoulos A. Gavriilaki E, et al. Ann Hematol. 2021 Aug;100(8):2139-2140. doi: 10.1007/s00277-020-04183-3. Epub 2020 Jul 18. Ann Hematol. 2021. PMID: 32683455 Free PMC article. No abstract available.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Phan LT, Nguyen TV, Luong QC, Nguyen TV, Nguyen HT, Le HQ, et al. Importation and human-to-human transmission of a novel coronavirus in Vietnam. N Engl J Med. 2020;382(9):872–874. doi: 10.1056/NEJMc2001272. - DOI - PMC - PubMed
    1. Rothe C, Schunk M, Sothmann P, Bretzel G, Froeschl G, Wallrauch C et al (2020) Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N Engl J MedN Engl J Med. 10.1056/NEJMc2001468 - PMC - PubMed
    1. Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H et al (2020) First case of 2019 novel coronavirus in the United States. N Engl J MedN Engl J Med. 10.1056/NEJMoa2001191 - PMC - PubMed
    1. Chen Z, Zhang W, Lu Y, Guo C, Guo Z, Liao C et al (2020) From SARS-CoV to Wuhan 2019-nCoV outbreak: similarity of early epidemic and prediction of future trends. BioRxiv. 10.1101/2020.01.24.919241
    1. The L. Emerging understandings of 2019-nCoV. Lancet. 2020;395(10221):311. doi: 10.1016/S0140-6736(20)30186-0. - DOI - PMC - PubMed

LinkOut - more resources