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Editorial
. 2020 Jul;50(1):33-42.
doi: 10.1007/s11239-020-02107-6.

Toward understanding the 2019 Coronavirus and its impact on the heart

Richard C Becker  1
Affiliations
Editorial

Toward understanding the 2019 Coronavirus and its impact on the heart

Richard C Becker. J Thromb Thrombolysis. 2020 Jul.
No abstract available

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Figures

Fig. 1
Fig. 1
Timelines for the SARs-CoV outbreak in 2002 and the more recent SARS-CoV-2 outbreak leading to COVID-19. Identification, responses and clinical impact are highlighted and contrasted. Severe acute respiratory syndrome (SARS); coronavirus (CoV); coronavirus-associated illness (COVID)-19 From Callaway E. Nature Briefing Newsletter. March 18, 2020. With permission
Fig. 2
Fig. 2
Cartoon representation showing the pre- to post-fusion transition of the SARS-CoV S glycoprotein. The ªdownº to ªupº transition of the receptor-binding domain (CTD1) allows receptor binding. The binding to ACE2 opens up CTD1 and CTD2, promotes the disassociation of the S1-ACE2 complex from the S1/S2 cleaved S glycoprotein, induces the pre- to post-fusion transition of the S2 subunit, and initiates the membrane fusion. Spike (S); angiotensin-converting enzyme (ACE); severe acute respiratory syndrome (SARS) From Song W. PLOS Pathogens 10.1371/journal.ppat.1007236 with permission
Fig. 3
Fig. 3
ACE2 receptors are expressed in multiple organs, with the greatest density and potential for upregulation in the lungs, heart and blood vessels (arteries and veins; macrovessels and microvessels). There is a direct relationship between ACE2 receptor density and target organ involvement and injury among patients with COVID-19 From Zou X. Front Med 10.1007/s11684-020-0754-0 with permission
See this image and copyright information in PMC

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