Meta-Analysis
doi: 10.1002/14651858.CD012626.pub2.
Interventions for promoting physical activity in people with chronic obstructive pulmonary disease (COPD)
Affiliations
- PMID: 32297320
- PMCID: PMC7160071
- DOI: 10.1002/14651858.CD012626.pub2
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Meta-Analysis
Interventions for promoting physical activity in people with chronic obstructive pulmonary disease (COPD)
Cochrane Database Syst Rev.
.
Abstract
Background: Escalating awareness of the magnitude of the challenge posed by low levels of physical activity in people with chronic obstructive pulmonary disease (COPD) highlights the need for interventions to increase physical activity participation. The widely-accepted benefits of physical activity, coupled with the increasing availability of wearable monitoring devices to objectively measure participation, has led to a dramatic rise in the number and variety of studies that aimed to improve the physical activity of people with COPD. However, little was known about the relative efficacy of interventions tested so far.
Objectives: In people with COPD, which interventions are effective at improving objectively-assessed physical activity?
Search methods: We identified trials from the Cochrane Airways Trials Register Register, which contains records identified from bibliographic databases including the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, CINAHL, AMED, and PsycINFO. We also searched PEDro, ClinicalTrials.gov, the World Health Organization International Clinical Trials Registry Platform portal and the Australian New Zealand Clinical Trials Registry (from inception to June 2019). We checked reference lists of all primary studies and review articles for additional references, as well as respiratory journals and respiratory meeting abstracts, to identify relevant studies.
Selection criteria: We included randomised controlled trials of interventions that used objective measures for the assessment of physical activity in people with COPD. Trials compared an intervention with no intervention or a sham/placebo intervention, an intervention in addition to another standard intervention common to both groups, or two different interventions.
Data collection and analysis: We used standard methods recommended by Cochrane. Subgroup analyses were possible for supervised compared to unsupervised pulmonary rehabilitation programmes in clinically-stable COPD for a range of physical activity outcomes. Secondary outcomes were health-related quality of life, exercise capacity, adverse events and adherence. Insufficient data were available to perform prespecified subgroup analyses by duration of intervention or disease severity. We undertook sensitivity analyses by removing studies that were at high or unclear risk of bias for the domains of blinding and incomplete outcome data.
Main results: We included 76 studies with 8018 participants. Most studies were funded by government bodies, although some were sponsored by equipment or drug manufacturers. Only 38 studies had physical activity as a primary outcome. A diverse range of interventions have been assessed, primarily in single studies, but improvements have not been systematically demonstrated following any particular interventions. Where improvements were demonstrated, results were confined to single studies, or data for maintained improvement were not provided. Step count was the most frequently reported outcome, but it was commonly assessed using devices with documented inaccuracy for this variable. Compared to no intervention, the mean difference (MD) in time in moderate- to vigorous-intensity physical activity (MVPA) following pulmonary rehabilitation was four minutes per day (95% confidence interval (CI) -2 to 9; 3 studies, 190 participants; low-certainty evidence). An improvement was demonstrated following high-intensity interval exercise training (6 minutes per day, 95% CI 4 to 8; 2 studies, 275 participants; moderate-certainty evidence). One study demonstrated an improvement following six months of physical activity counselling (MD 11 minutes per day, 95% CI 7 to 15; 1 study, 280 participants; moderate-certainty evidence), but we found mixed results for the addition of physical activity counselling to pulmonary rehabilitation. There was an improvement following three to four weeks of pharmacological treatment with long-acting muscarinic antagonist and long-acting beta2-agonist (LAMA/LABA) compared to placebo (MD 10 minutes per day, 95% CI 4 to 15; 2 studies, 423 participants; high-certainty evidence). These interventions also demonstrated improvements in other measures of physical activity. Other interventions included self-management strategies, nutritional supplementation, supplemental oxygen, endobronchial valve surgery, non-invasive ventilation, neuromuscular electrical stimulation and inspiratory muscle training.
Authors' conclusions: A diverse range of interventions have been assessed, primarily in single studies. Improvements in physical activity have not been systematically demonstrated following any particular intervention. There was limited evidence for improvement in physical activity with strategies including exercise training, physical activity counselling and pharmacological management. The optimal timing, components, duration and models for interventions are still unclear. Assessment of quality was limited by a lack of methodological detail. There was scant evidence for a continued effect over time following completion of interventions, a likely requirement for meaningful health benefits for people with COPD.
Copyright © 2020 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Conflict of interest statement
Angela Burge received a PhD stipend from the National Health and Medical Research Council (NHMRC), Australia. This Cochrane Review forms a part of those PhD studies. The National Health and Medical Research Council (NHMRC) supports the independent conduct and publication of this Cochrane Review.
Narelle Cox is the holder of a NHMRC Early Career Fellowship. She presented workshops relating to pulmonary rehabilitation at the 2018 National General Practitioners Meeting sponsored by Boeringher Ingelheim.
Michael Abramson holds investigator‐initiated grants from Pfizer and Boehringer‐Ingelheim for unrelated research, undertook unrelated consultancies for AstraZeneca and Sanofi, and received assistance with conference attendance from Boehringer‐Ingelheim and Sanofi.
Anne Holland has received fees from AstraZeneca and Boehringer Ingelheim for non‐promotional speaking engagements (unrelated to the present work).
Three review authors (AB, NC and AH) were co‐authors on an included study (Holland 2017), so an independent co‐author (MA) undertook the assessment of risks of bias.
Figures
Study flow diagram.
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Forest plot of comparison 1: Intervention vs. no intervention Outcome 1.1: Physical activity: change in step count (steps per day)
Forest plot of comparison 1: Intervention vs. no intervention Outcome 1.2: Physical activity: change in time in moderate‐to‐vigorous intensity physical activity (minutes per day)
Forest plot of comparison 1: Intervention vs. no intervention Outcome 1.4: Physical activity: change in time in light‐intensity physical activity (minutes per day)
Forest plot of comparison 1: Intervention vs. no intervention Outcome 1.3: Physical activity: change in total energy expenditure (kcal)
Forest plot of comparison 1: Intervention vs. no intervention Outcome 1.6: Physical activity: change in time in physical activity (total, minutes per day)
Forest plot of comparison 1: Intervention vs. no intervention Outcome 1.5: Physical activity: change in sedentary time (minutes per day)
Forest plot of comparison 1: Intervention vs. no intervention Outcome: 1.8 Physical activity: time in "lifestyle" physical activity (minutes per day)
Forest plot of comparison: 1 Intervention vs. no intervention Outcome: 1.7 Physical activity: time in light‐intensity physical activity (minutes per day)
Forest plot of comparison 1: Intervention vs. vs. no intervention Outcome 1.9: Physical activity: time in MVPA (minutes per day)
Forest plot of comparison 1: Intervention vs. no intervention Outcome 1.10: Physical activity: sedentary time (minutes per day)
Forest plot of comparison 2: Intervention vs. placebo Outcome 2.2: Physical activity: change in step count (steps per day)
Forest plot of comparison 2: Intervention vs. placebo Outcome 2.3: Physical activity: change in time in moderate‐to‐vigorous intensity physical activity (minutes per day)
Forest plot of comparison 2: Intervention vs. placebo Outcome 2.4: Physical activity: change in active energy expenditure (kcal)
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 1 change in step count (steps per day); Intervention: pulmonary rehabilitation/exercise training.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 2 time/change in time in moderate‐to‐vigorous intensity physical activity (minutes per day); Intervention: pulmonary rehabilitation/exercise training.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 3 change in time in light‐intensity physical activity (minutes per day); Intervention: pulmonary rehabilitation/exercise training.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 4 change in total energy expenditure (kcal); Intervention: pulmonary rehabilitation/exercise training.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 5 change in time in physical activity (total; minutes per day); Intervention: pulmonary rehabilitation/exercise training.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 6 change in sedentary time (minutes per day); Intervention: pulmonary rehabilitation/exercise training.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 7 time in "lifestyle" physical activity (minutes per day); Intervention: high‐intensity interval training.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 8 time in light‐intensity physical activity (minutes per day); Intervention: high‐intensity interval training.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 9 time in moderate‐to‐vigorous intensity physical activity (minutes per day); Intervention: high‐intensity interval training.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 10 sedentary time (minutes per day); Intervention: high‐intensity interval training.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 11 step count (steps per day); Intervention: physical activity counselling.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 12 "IMA" (counts per minute); Intervention: self‐management.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 13 physical activity level; Intervention: nutritional supplement.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 14 total energy expenditure (MJ); Intervention: nutritional supplement.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 15 subgroup analysis (supervised vs. unsupervised); change in step count (steps per day); Intervention: pulmonary rehabilitation/exercise training.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 16 supgroup analysis (supervised vs. unsupervised); change in time in light‐intensity physical activity (minutes per day); Intervention: pulmonary rehabilitation/exercise training.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 17 subgroup analysis (supervised vs. unsupervised); change in total energy expenditure (kcal); Intervention: pulmonary rehabilitation/exercise training.
Comparison 1 Physical activity: intervention vs. no intervention, Outcome 18 subgroup analysis (supervised vs. unsupervised); change in sedentary time (minutes per day); Intervention: pulmonary rehabilitation/exercise training.
Comparison 2 Physical activity: intervention vs. placebo/sham, Outcome 1 step count (steps per day); Intervention: self‐management (health mentoring).
Comparison 2 Physical activity: intervention vs. placebo/sham, Outcome 2 change in step count (steps per day); Intervention: LAMA/LABA.
Comparison 2 Physical activity: intervention vs. placebo/sham, Outcome 3 change in time in moderate‐to‐vigorous intensity physical activity (minutes per day): Intervention: LAMA/LABA.
Comparison 2 Physical activity: intervention vs. placebo/sham, Outcome 4 change in active energy expenditure (kcal); Intervention: LAMA/LABA.
Comparison 2 Physical activity: intervention vs. placebo/sham, Outcome 5 step count (steps per day); Intervention: nutritional supplement.
Comparison 2 Physical activity: intervention vs. placebo/sham, Outcome 6 energy expenditure for ambulation (kcal/step/FFM kg); Intervention: nutritional supplement.
Comparison 2 Physical activity: intervention vs. placebo/sham, Outcome 7 change in step count (steps per day); Intervention: neuromuscular electrical stimulation.
Comparison 2 Physical activity: intervention vs. placebo/sham, Outcome 8 change in up/down transitions (number); Intervention: neuromuscular electrical stimulation.
Comparison 2 Physical activity: intervention vs. placebo/sham, Outcome 9 change in time upright (hours); Intervention: neuromuscular electrical stimulation.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 1 movement intensity (m/s2); Interventions: nordic walking with education vs. education.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 2 change in step count (steps per day); Interventions: exercise training (COPE‐active) with self‐management vs. self management.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 3 change in time in light‐intensity physical activity (minutes per day); Interventions: upper body resistance training with health education vs. health education.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 4 step count (steps per day); Interventions: LAMA/LABA and exercise training with behaviour modification vs. placebo with behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 5 time walking (minutes per day); Interventions: LAMA/LABA and exercise training with behaviour modification vs. placebo with behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 6 walking intensity (m/s2); Interventions: LAMA/LABA and exercise training with behaviour modification vs. placebo with behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 7 step count (steps per day); Interventions: exercise training and LABA with LAMA and behaviour modification vs. LAMA and behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 8 time walking (minutes per day); Interventions: exercise training and LABA with LAMA and behaviour modification vs. LAMA and behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 9 walking intensity (m/s2); Interventions: exercise training and LABA with LAMA and behaviour modification vs. LAMA and behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 10 step count (steps per day); Interventions: exercise training with LAMA/LABA and behaviour modification vs. LAMA/LABA and behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 11 time walking (minutes per day); Interventions: exercise training with LAMA/LABA and behaviour modification vs. LAMA/LABA and behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 12 walking intensity (m/s2); Interventions: exercise training with LAMA/LABA and behaviour modification vs. LAMA/LABA and behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 13 change in step count (steps per day); Interventions: exercise training and physical activity counselling with pedometer vs. pedometer.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 14 change in step count (weekday, steps per day); Interventions: physical activity counselling with optional supervised exercise vs. optional supervised exercise.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 15 METs; Interventions: physical activity counselling with optional supervised exercise vs. optional supervised exercise.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 16 step count (steps per day); Interventions: physical activity counselling with pedometer vs. pedometer.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 17 time active (minutes per day); Interventions: physical activity counselling (app) with pedometer vs. pedometer.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 18 time inactive (minutes per day); Interventions: physical activity counselling (app) with pedometer vs. pedometer.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 19 peak performance (steps per minute); Interventions: physical activity counselling (app) with pedometer vs. pedometer.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 20 step count (steps per day); Interventions: physical activity counselling with pulmonary rehabilitation vs. pulmonary rehabilitation.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 21 time in moderate‐to‐vigorous intensity physical activity (minutes per day); Interventions: physical activity counselling with pulmonary rehabilitation vs. pulmonary rehabilitation.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 22 time in physical activity (total, minutes per day); Interventions: physical activity counselling with pulmonary rehabilitation vs. pulmonary rehabilitation.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 23 time sedentary (minutes per day); Interventions: physical activity counselling with pulmonary rehabilitation vs. pulmonary rehabilitation.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 24 change in step count (steps per day); Interventions: physical activity counselling with pulmonary rehabilitation vs. sham with pulmonary rehabilitation.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 25 change in time in moderate‐to‐vigorous intensity physical activity (minutes per day); Interventions: physical activity counselling with pulmonary rehabilitation vs. sham with pulmonary rehabilitation.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 26 change in time walking (minutes per day); Interventions: physical activity counselling with pulmonary rehabilitation vs. sham with pulmonary rehabilitation.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 27 change in time in physical activity (total, minutes per day); Interventions: physical activity counselling with pulmonary rehabilitation vs. sham with pulmonary rehabilitation.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 28 change in time in light‐intensity physical activity (minutes per day); Interventions: exercise‐specific self‐efficacy training with upper body resistance training vs. upper body resistance training.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 29 step count (steps per day); Interventions: LAMA with behaviour modification vs. placebo with behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 30 time walking (minutes per day); Interventions: LAMA with behaviour modification vs. placebo with behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 31 walking intensity (m/s2); Interventions: LAMA with behaviour modification vs. placebo with behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 32 step count (steps per day); Interventions: LAMA/LABA with behaviour modification vs. placebo with behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 33 time walking (minutes per day); Interventions: LAMA/LABA with behaviour modification vs. placebo with behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 34 walking intensity (m/s2); Interventions: LAMA/LABA with behaviour modification vs. placebo with behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 35 step count (steps per day); Interventions: LABA with LAMA and behaviour modification vs. LAMA and behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 36 time walking (minutes per day); Interventions: LABA with LAMA and behaviour modification vs. LAMA and behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 37 walking intensity (m/s2); Interventions: LABA with LAMA and behaviour modification vs. LAMA and behaviour modification.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 38 change in step count (steps per day); Interventions: nutritional supplement with pulmonary rehabilitation vs. placebo with pulmonary rehabilitation.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 39 change in step count (steps per day); Interventions: supplemental oxygen with pulmonary rehabilitation vs. sham with pulmonary rehabilitation.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 40 change in time in moderate‐intensity physical activity (minutes per day); Interventions: supplemental oxygen with pulmonary rehabilitation vs. sham with pulmonary rehabilitation.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 41 change in time in vigorous‐intensity physical activity (minutes per day); Interventions: supplemental oxygen with pulmonary rehabilitation vs. sham with pulmonary rehabilitation.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 42 change in time in light‐intensity physical activity (minutes per day); Interventions: supplemental oxygen with pulmonary rehabilitation vs. sham with pulmonary rehabilitation.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 43 change in total energy expenditure (kcal); Interventions: supplemental oxygen with pulmonary rehabilitation vs. sham with pulmonary rehabilitation.
Comparison 3 Physical activity: intervention with common intervention vs. common intervention, Outcome 44 change in sedentary time (minutes per day); Interventions: supplemental oxygen with pulmonary rehabilitation vs. sham with pulmonary rehabilitation.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 1 change in step count (steps per day); Interventions: home‐based pulmonary rehabilitation vs. centre‐based pulmonary rehabilitation.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 2 change in time in moderate‐to‐vigorous intensity physical activity (minutes per day); Interventions: home‐based pulmonary rehabilitation vs. centre‐based pulmonary rehabilitation.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 3 change in number of bouts of moderate‐to‐vigorous intensity physical activity; Interventions: home‐based pulmonary rehabilitation vs. centre‐based pulmonary rehabilitation.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 4 change in time in bouts of moderate‐to‐vigorous intensity physical activity(minutes per day); Interventions: home‐based pulmonary rehabilitation vs. centre‐based pulmonary rehabilitation.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 5 change in sedentary time (minutes per day); Interventions: home‐based pulmonary rehabilitation vs. centre‐based pulmonary rehabilitation.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 6 change in sedentary time (awake; minutes per day); Interventions: home‐based pulmonary rehabilitation vs. centre‐based pulmonary rehabilitation.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 7 change in number of sedentary bouts; Interventions: home‐based pulmonary rehabilitation vs. centre‐based pulmonary rehabilitation.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 8 change in time in sedentary bouts (minutes per day); Interventions: home‐based pulmonary rehabilitation vs. centre‐based pulmonary rehabilitation.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 9 change in METs; Interventions: home‐based pulmonary rehabilitation vs. centre‐based pulmonary rehabilitation.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 10 change in total energy expenditure (kcal); Interventions: home‐based pulmonary rehabilitation vs. centre‐based pulmonary rehabilitation.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 11 change in step count (steps per day); Interventions: water‐based exercise training vs. land‐based exercise training.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 12 change in total energy expenditure (kcal); Interventions: water‐based exercise training vs. land‐based exercise training.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 13 step count (steps per day); Interventions: Tai Chi vs. pulmonary rehabilitation.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 14 step count (steps per day); Interventions: outdoor walking vs. cycle ergometry.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 15 step count (steps per day); Interventions: physical activity counselling vs. pulmonary rehabilitation.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 16 total energy expenditure (kcal); Interventions: exercise training with tapered supervision vs. supervised exercise training.
Comparison 4 Physical activity: intervention vs. intervention, Outcome 17 mid day activity (vector magnitude units per minute); Interventions: supplemental oxygen (lightweight ambulatory) vs. supplemental oxygen (E‐cylinder).
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 1 change in SGRQ total score; Intervention: pulmonary rehabilitation/exercise training.
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 2 change in SGRQ domain scores. Intervention: pulmonary rehabilitation/exercise training (ground‐based walking).
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 3 change in CRQ domain scores; Intervention: pulmonary rehabilitation/exercise training.
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 4 CAT score; Intervention: high‐intensity interval training.
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 5 SGRQ domain scores (%change); Intervention: exercise training [inpatient].
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 6 SGRQ domain scores; Intervention: physical activity counselling.
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 7 CCQ domain scores: Intervention: physical activity counselling.
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 8 change in CCQ domain scores; Intervention: physical activity counselling (telecoaching).
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 9 change in CRQ domain and total scores; Intervention: physical activity counselling.
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 10 change in SGRQ domain and total scores; Intervention: physical activity counselling.
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 11 change in CRQ domain scores; Intervention: self‐management (SPACE).
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 12 CCQ total score; Intervention: self‐management.
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 13 EQ5D index score; Intervention: self‐management.
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 14 EQ5D visual analogue scale score; Intervention: self‐management.
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 15 SGRQ domain scores; Intervention: self‐management (telephone health coaching).
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 16 EQ5D score; Intervention: self‐management (telephone health coaching).
Comparison 5 Health‐related quality of life: intervention vs. no intervention, Outcome 17 CRQ domain scores; Intervention: four‐wheeled walker.
Comparison 6 Health‐related quality of life: intervention vs. placebo/sham, Outcome 1 change in SF36 component scores; Intervention: singing.
Comparison 6 Health‐related quality of life: intervention vs. placebo/sham, Outcome 2 change in CRQ total score; Intervention: neuromuscular electrical stimulation.
Comparison 6 Health‐related quality of life: intervention vs. placebo/sham, Outcome 3 change in SGRQ total score; Intervention: neuromuscular electrical stimulation.
Comparison 6 Health‐related quality of life: intervention vs. placebo/sham, Outcome 4 change in EQ5D index score; Intervention: neuromuscular electrical stimulation.
Comparison 6 Health‐related quality of life: intervention vs. placebo/sham, Outcome 5 change in EQ5D visual analogue scale score; Intervention: neuromuscular electrical stimulation.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 1 SF36 component scores (score < 50); Interventions: Nordic walking with education vs. education.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 2 change in CRQ domain scores; Interventions: exercise training (COPE‐active) with self‐management vs. self management.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 3 change in CCQ domain scores; Interventions: exercise training (COPE‐active) with self‐management vs. self management.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 4 CRQ domain scores; Interventions: LAMA/LABA and exercise training with behaviour modification vs. placebo with behaviour modification.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 5 CRQ domain scores; Interventions: exercise training and LABA with LAMA and behaviour modification vs. LAMA and behaviour modification.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 6 CRQ domain scores; Interventions: exercise training with LAMA/LABA and behaviour modification vs. LAMA/LABA and behaviour modification.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 7 change in SGRQ domain and total scores; Intervention: exercise training and physical activity counselling with pedometer vs. pedometer.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 8 change in CRQ domain scores; Interventions: physical activity counselling (app) with optional supervised exercise vs. optional supervised exercise.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 9 change in SGRQ total score; Interventions: physical activity counselling with pedometer vs. pedometer.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 10 SGRQ total: Interventions: physical activity counselling (app) with pedometer vs. pedometer.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 11 SF36: Interventions: physical activity counselling (app) with pedometer vs. pedometer.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 12 change in SGRQ domain scores; Interventions: physical activity counselling (web‐based) with pedometer vs. pedometer.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 13 SGRQ domain scores; Interventions: physical activity counselling with pulmonary rehabilitation vs. pulmonary rehabilitation.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 14 RAND36 domain scores; Interventions: physical activity counselling with pulmonary rehabilitation vs. pulmonary rehabilitation.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 15 change in CRQ dyspnoea domain score; Interventions: physical activity counselling with pulmonary rehabilitation vs. pulmonary rehabilitation.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 16 SGRQ scores; Interventions: physical activity counselling with pulmonary rehabilitation vs. pulmonary rehabilitation.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 17 CRQ domain scores; Interventions: physical activity counselling with pulmonary rehabilitation vs. pulmonary rehabilitation.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 18 change in CRQ total score; Interventions: physical activity counselling with pulmonary rehabilitation vs. sham intervention with pulmonary rehabilitation.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 19 change in CRQ scores; Interventions: self‐management (health coaching) with pulmonary rehabilitation referral vs. pulmonary rehabilitation referral.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 20 CRQ domain scores; Interventions: LAMA with behaviour modification vs. placebo with behaviour modification.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 21 CRQ domain scores; Interventions: LAMA/LABA with behaviour modification vs. placebo with behaviour modification.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 22 CRQ domain scores; Interventions: LABA with LAMA and behaviour modification vs. LAMA and behaviour modification.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 23 change in SGRQ domain and total scores; Interventions: ACE inhibitor with pulmonary rehabilitation vs. placebo with pulmonary rehabilitation.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 24 change in SGRQ total score; Interventions: nutritional supplement with pulmonary rehabilitation vs. placebo with pulmonary rehabilitation.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 25 change in EQ5D; Interventions: nutritional supplement with pulmonary rehabilitation vs. placebo with pulmonary rehabilitation.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 26 change in CRQ domain scores; Interventions: supplemental oxygen with pulmonary rehabilitation vs. sham intervention with pulmonary rehabilitation.
Comparison 7 Health‐related quality of life: intervention with common intervention vs. common intervention, Outcome 27 CRQ domain scores; Interventions: non‐invasive ventilation with pulmonary rehabilitation vs. pulmonary rehabilitation.
Comparison 8 Exercise capacity: intervention vs. placebo/sham, Outcome 1 change in 6MWD (metres); Intervention; neuromuscular electrical stimulation.
Comparison 9 Exercise capacity: intervention vs. no intervention, Outcome 1 change in 6MWD (metres); Intervention: pulmonary rehabilitation/exercise training.
Comparison 9 Exercise capacity: intervention vs. no intervention, Outcome 2 change in ISWD (metres); Intervention: pulmonary rehabilitation/exercise training.
Comparison 9 Exercise capacity: intervention vs. no intervention, Outcome 3 change in ESWT (seconds); Intervention: pulmonary rehabilitation/exercise training.
Comparison 9 Exercise capacity: intervention vs. no intervention, Outcome 4 6MWD (metres); Intervention: high‐intensity interval training.
Comparison 9 Exercise capacity: intervention vs. no intervention, Outcome 5 work rate (watts); Intervention: high‐intensity interval training.
Comparison 9 Exercise capacity: intervention vs. no intervention, Outcome 6 change in ISWD (metres); Intervention: self‐management (SPACE).
Comparison 9 Exercise capacity: intervention vs. no intervention, Outcome 7 change in ESWT (seconds); Intervention: self‐management (SPACE).
Comparison 9 Exercise capacity: intervention vs. no intervention, Outcome 8 6MWD (metres); Intervention: exercise training [inpatient].
Comparison 10 Health‐related quality of life: intervention vs. intervention, Outcome 1 change in CRQ domains; Interventions: home‐based pulmonary rehabilitation vs. centre‐based pulmonary rehabilitation.
Comparison 10 Health‐related quality of life: intervention vs. intervention, Outcome 2 change in CRQ domains; Interventions: water‐based exercise training vs. land‐based exercise training.
Comparison 10 Health‐related quality of life: intervention vs. intervention, Outcome 3 SGRQ domain and total scores; Interventions: Tai Chi vs. pulmonary rehabilitation.
Comparison 10 Health‐related quality of life: intervention vs. intervention, Outcome 4 CRQ total score; Interventions: outdoor walking vs. cycle ergometry.
Comparison 10 Health‐related quality of life: intervention vs. intervention, Outcome 5 Maugeri Respiratory Failure questionnaire; Interventions: exercise training with tapered supervision vs. supervised exercise training.
Comparison 10 Health‐related quality of life: intervention vs. intervention, Outcome 6 SF36 domain scores; Interventions: self‐management vs. education and symptom monitoring.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 1 6MWD (metres); Interventions: Nordic walking with education vs. education.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 2 change in ISWD (metres); Interventions: exercise training (COPE‐active) with self‐management vs. self management.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 3 change in ESWT (seconds); Interventions: exercise training (COPE‐active) with self‐management vs. self management.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 4 6MWD (metres); Interventions: exercise training and LAMA/LABA with behaviour modification vs. placebo with behaviour modification.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 5 ESWT (seconds); Interventions: exercise training and LAMA/LABA with behaviour modification vs. placebo with behaviour modification.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 6 6MWD (metres); Interventions: exercise training and LABA with LAMA and behaviour modification vs. LAMA and behaviour modification.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 7 ESWT (seconds); Interventions: exercise training and LABA with LAMA and behaviour modification vs. LAMA and behaviour modification.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 8 6MWD (metres); Interventions: exercise training with LAMA/LABA and behaviour modification vs. LAMA/LABA and behaviour modification.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 9 ESWT (seconds); Interventions: exercise training with LAMA/LABA and behaviour modification vs. LAMA/LABA and behaviour modification.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 10 change in ESWT (seconds); Intervention: physical activity counselling and exercise training with pedometer vs. pedometer.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 11 6MWD (metres); Interventions: physical activity counselling (app) with optional supervised exercise vs. optional supervised exercise.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 12 6MWD (metres); Interventions: physical activity counselling (app) with pedometer vs. pedometer.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 13 6MWD (metres); Interventions: physical activity counselling with pulmonary rehabilitation vs. pulmonary rehabilitation.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 14 change in 6MWD (metres); Interventions: physical activity counselling with pulmonary rehabilitation vs. sham with pulmonary rehabilitation.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 15 6MWD (metres); Interventions: LAMA with behaviour modification vs. placebo with behaviour modification.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 16 ESWT (seconds); Interventions: LAMA with behaviour modification vs. placebo with behaviour modification.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 17 6MWD (metres); Interventions: LAMA/LABA with behaviour modification vs. placebo with behaviour modification.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 18 ESWT (s); Interventions: LAMA/LABA with behaviour modification vs. placebo with behaviour modification.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 19 6MWD (metres); Interventions: LAMA/LABA with behaviour modification vs. LAMA with behaviour modification.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 20 ESWT (seconds); Interventions: LAMA/LABA with behaviour modification vs. LAMA with behaviour modification.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 21 change in ISWD (metres); Interventions: supplemental oxygen with pulmonary rehabilitation vs. sham intervention with pulmonary rehabilitation.
Comparison 11 Exercise capacity: intervention with common intervention vs. common intervention, Outcome 22 change in ESWT (seconds); Interventions: supplemental oxygen with pulmonary rehabilitation vs. sham intervention with pulmonary rehabilitation.
Comparison 12 Exercise capacity: intervention vs. intervention, Outcome 1 change in 6MWD (metres); Interventions: home‐based pulmonary rehabilitation vs. centre‐based pulmonary rehabilitation.
Comparison 12 Exercise capacity: intervention vs. intervention, Outcome 2 change in 6MWD (metres); Interventions: water‐based exercise training vs. land‐based exercise training.
Comparison 12 Exercise capacity: intervention vs. intervention, Outcome 3 change in ISWD (metres); Interventions: water‐based exercise training vs. land‐based exercise training.
Comparison 12 Exercise capacity: intervention vs. intervention, Outcome 4 change in VO2max (ml/min); Interventions: water‐based exercise training vs. land‐based exercise training.
Comparison 12 Exercise capacity: intervention vs. intervention, Outcome 5 6MWD (metres); Interventions: Tai Chi vs. pulmonary rehabilitation.
Comparison 12 Exercise capacity: intervention vs. intervention, Outcome 6 6MWD (metres); Interventions: exercise training with tapered supervision vs. supervised exercise training.
Update of
References
References to studies included in this review
Alison 2019 {published data only}
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- Alison JA, McKeough ZJ, Leung RW, Holland AE, Hill K, Morris NR, et al. Oxygen compared to air during exercise training in COPD with exercise‐induced desaturation. European Respiratory Journal 2019;53:1802429. - PubMed
Altenburg 2015 {published data only}
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- Altenburg W, Wempe J, Greef M, Hacken N, Kerstjens H. Short‐ and long‐term effects of a physical activity counselling program in COPD [abstract]. European Respiratory Journal 2014;44:3490.
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Arbillaga‐Etxarri 2018 {published data only}
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Beeh 2014 {published and unpublished data}
Bender 2016 {published data only}
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- Bender BG, Make BJ, Emmett A, Sharma S, Stempel D. Enhancing physical activity in patients with chronic obstructive pulmonary disease (COPD) through a program of patient selected goals [abstract]. American Journal of Respiratory and Critical Care Medicine 2015;191:A2458.
Benzo 2016 {published data only (unpublished sought but not used)}
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Blumenthal 2014 {published data only}
Borges 2014 {published and unpublished data}
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- Borges R, Carvalho CR. Effect of resistance training during hospitalization in the systemic inflammation, functional capacity and muscle strength in COPD patients [abstract]. European Respiratory Journal 2011;38:1890.
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Breyer 2010 {published data only (unpublished sought but not used)}
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Burtin 2015 {published data only}
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Casaburi 2012 {published data only}
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Chaplin 2017 {published data only}
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Charususin 2018 {published data only}
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Cruz 2016 {published data only}
Curtis 2016 {published data only}
Dal Negro 2012 {published data only (unpublished sought but not used)}
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De Blok 2006 {published data only}
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Demeyer 2017 {published and unpublished data}
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De Roos 2017 {published and unpublished data}
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Duiverman 2008 {published data only}
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Effing 2011 {published data only}
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Egan 2010 {published and unpublished data}
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Felcar 2018 {published data only}
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- Felcar JM, Probst VS, Carvalho DR, Merli MF, Mesquita RB, Vidotto LS, et al. Effects of exercise training in water and on land in patients with COPD [abstract]. European Respiratory Journal 2015;46(Suppl 59):PA2396.
Gamper 2019 {published data only}
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- Gamper E, Schmidt U, Bansi J, Kool J. Outdoor walking training compared to cycle ergometer training in severe COPD: a randomized controlled feasibility trial. COPD: Journal of Chronic Obstructive Pulmonary Disease 2019;16(1):37‐44. - PubMed
Goris 2003 {published data only}
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Hartman 2016 {published data only}
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- Hartman JE, Klooster K, Slebos DJ, Hacken NH. Daily physical activity significantly improves after endobronchial valve treatment in patients with emphysema [abstract]. European Respiratory Journal 2015;46:OA1767.
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- Hartman JE, Klooster K, Slebos DJ, Hacken NH. Improvement of physical activity after endobronchial valve treatment in emphysema patients. Respiratory Medicine 2016;117:116‐21. - PubMed
Holland 2017 {published data only}
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- Holland AE, Mahal A, Hill CJ, Lee AL, Burge AT, Cox NS, et al. Low cost home‐based pulmonary rehabilitation for chronic obstructive pulmonary disease: a randomized controlled equivalence trial [abstract]. American Journal of Respiratory and Critical Care Medicine 2016;193:A2620.
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Hornikx 2015 {published data only}
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- Hornikx M, Demeyer H, Camillo CA, Janssens W, Troosters T. The effects of physical activity coaching in patients with COPD after an acute exacerbation [abstract]. European Respiratory Journal 2014;44:1920.
Hospes 2009 {published data only (unpublished sought but not used)}
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- Hospes G, Bossenbroek L, Hacken NH, Hengel P, Greef MH. Enhancement of daily physical activity increases physical fitness of outclinic COPD patients: results of an exercise counseling program. Patient Education and Counseling 2009;75(2):274‐8. - PubMed
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Jolly 2018 {published data only}
Kanabar 2015 {published and unpublished data}
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- Kanabar P, Warrington V, Houchen‐Wolloff L, Singh SJ. Investigating the profile of physical activity in COPD patients 7 days post discharge from a respiratory‐related admission. Does brief advice have an effect? [abstract]. Thorax 2015;70(Suppl 3):A146.
Kawagoshi 2015 {published data only}
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- Kawagoshi A, Kiyokawa N, Iwakura M, Okura K, Sugawara K, Takahashi H, Sakata S, Satake M, Shioya T. Effects of low‐intensity exercise and home‐based pulmonary rehabilitation with pedometer feedback on physical activity in elderly patients with COPD [abstract]. European Respiratory Journal 2015;46:PA3563. - PubMed
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Larson 2014 {published data only (unpublished sought but not used)}
Loeckx 2018 {published data only}
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- Loeckx M, Rodrigues F, Demeyer H, Janssens W, Troosters T. Improving physical activity to obtain sustainable benefits in extra‐pulmonary consequences of COPD after pulmonary rehabilitation: a randomized controlled trial [abstract]. American Journal of Respiratory and Critical Care Medicine 2018;197:A2452.
Lord 2012 {published data only (unpublished sought but not used)}
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- Lord VM, Hume VJ, Kelly JL, Cave P, Silver J, Waldman M, et al. Effects of 'singing for breathing' in patients with chronic obstructive pulmonary disease (COPD) ‐ a randomized controlled trial [abstract]. American Journal of Respiratory and Critical Care Medicine 2012;185:A5788.
Louvaris 2016 {published and unpublished data}
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- Kortianou E, Louvaris Z, Spetsioti S, Vasilopoulou M, Chynkiamis N, Nasis I, et al. High‐intensity interval exercise training improves daily physical activity levels in COPD [abstract]. European Respiratory Journal 2014;44(Suppl 58):1709.
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- Louvaris Z, Spetsioti S, Kortianou EA, Vasilopoulou M, Nasis I, Kaltsakas G, et al. Aerobic interval training induces clinically meaningful effects in daily physical activity in COPD [abstract]. European Respiratory Journal 2016;48:PA2053. - PubMed
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- Louvaris Z, Spetsioti S, Kortianou EA, Vasilopoulou M, Nasis I, Kaltsakas G, et al. Interval training induces clinically meaningful effects in daily activity levels in COPD. European Respiratory Journal 2016;48(2):567‐70. - PubMed
Maddocks 2016 {published data only}
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- Maddocks M, Nolan CM, Man WD, Polkey MI, Hart N, Gao W, et al. Neuromuscular electrical stimulation to improve exercise capacity in patients with severe COPD: a randomised double‐blind, placebo‐controlled trial. Lancet Respiratory Medicine 2016;4(1):27‐36. - PubMed
Magnussen 2017 {published and unpublished data}
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- Magnussen H, Arzt M, Andrea S, Plate T, Ribera A, Seoane B, et al. Aclidinium bromide improves symptoms and sleep quality in COPD: a pilot study. European Respiratory Journal 2017;49(6):1700485. - PubMed
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- Magnussen H, Arzt M, Andreas S, Plate T, Ribera A, Seoane B, et al. The effect of aclidinium bromide 400µg on lung function, sleep quality and physical activity in patients with chronic obstructive pulmonary disease: results of a phase IV pilot study [abstract]. American Journal of Respiratory and Critical Care Medicine 2016;193:A6820.
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- Magnussen H, Arzt M, Andreas S, Plate T, Ribera A, Seoane B, et al. The effect of aclidinium bromide 400µg on sleep quality in COPD: a pilot study [abstract]. European Respiratory Journal 2016;48:PA4051. - PubMed
Mantoani 2018 {published data only}
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- Mantoani L, McKinstry B, McNarry S, Mullen S, Begg S, Saini P, et al. Physical activity enhancing programme (PAEP) in COPD – a randomised controlled trial [abstract]. European Respiratory Journal 2018;52(Suppl 62):OA1986.
Mendoza 2015 {published data only}
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- Mendoza L, Aguilera M, Balmaceda N, Espinoza J, Horta P, Castro A, et al. Effect of a program of physical activity enhancement using pedometers in patients with chronic obstructive pulmonary disease [abstract]. American Journal of Respiratory and Critical Care Medicine 2013;187:A1360.
Mitchell 2013 {published and unpublished data}
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- Mitchell KE, Johnson‐Warrington V, Apps LD, Bankart J, Sewell L, Williams JE, et al. A self‐management programme for COPD: a randomised controlled trial. European Respiratory Journal 2014;44(6):1538‐47. - PubMed
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- Mitchell‐Wagg K, Warrington V, Apps L, Sewell L, Bankart J, Steiner MC, et al. A self‐management programme of activity coping and education (SPACE) for COPD: results from a randomised controlled trial [abstract]. Thorax 2012;67(Suppl 2):A25.
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- Wagg K, Warrington V, Apps L, Sewell L, Bankart J, Steiner M, et al. A self‐management programme of activity coping and education (SPACE) for COPD: 6 week results from a randomised controlled trial [abstract]. European Respiratory Journal 2012;40(Suppl 56):548s.
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Moy 2015a {published data only}
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- Martinez CH, Moy ML, Nguyen HQ, Cohen M, Kadri R, Roman P, et al. Taking healthy steps: rationale, design and baseline characteristics of a randomized trial of a pedometer‐based internet‐mediated walking program in veterans with chronic obstructive pulmonary disease. BMC Pulmonary Medicine 2014;14:12. - PMC - PubMed
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Nakamura 2016 {published data only}
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NCT00144326 {published data only}
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- García Río F. A randomised, double‐blind, placebo‐controlled, 12 weeks trial to evaluate the effect of tiotropium inhalation capsules on the magnitude of exercise, measured using an accelerometer, in patients with chronic obstructive pulmonary disease. Boehringer Ingelheim Trial Results 2007; Vol. Trial number 205.269 (first received 5 September 2005).
NCT01351792 {published data only}
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- NCT01351792. Multicentre, randomized research study to test the safety and efficacy of Foster® compared to Symbicort® on small airway function in patients with COPD. Chiesi Clinical Study Report (first received 11 May 2011). [Study number CCD‐1007‐PR‐0045]
Ng 2015 {published and unpublished data}
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- Ng LW, Jenkins S, Cecins N, Eastwood P, Hill K. A wheeled walker improves physical activity in chronic obstructive pulmonary disease [abstract]. Physiotherapy 2015;101:eS1084.
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- Ng LW, Jenkins S, Cecins N, Eastwood P, Hill K. The effect of using a wheeled walker on physical activity in people with COPD: preliminary data [abstract]. Respirology 2012;17(Suppl 1):60.
Nguyen 2009 {published data only}
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- Estrada EL, Silva K, Medina E, Desai S, Fan VS, Nguyen HQ. Depression and anxiety are associated with COPD patients' lower confidence for increasing physical activity but not with their motivation [abstract]. American Journal of Respiratory and Critical Care Medicine 2018;197:A7066.
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- Lee JS, Liu AI, Pounds D, Mahmud F, Flores C, Desai SA, et al. Characteristics of COPD patients who agree to participate in a pragmatic trial of physical activity coaching compared to non‐participants [abstract]. American Journal of Respiratory and Critical Care Medicine 2018;197:A2642.
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- Mahmud F, Valmonte F, Medina E, Pounds D, Nguyen HQ. Real‐world implementation of a physical activity coaching program [abstract]. American Journal of Respiratory and Critical Care Medicine 2018;197:A2728.
Nolan 2017 {published and unpublished data}
-
- Nolan CM, Maddocks M, Canavan JL, Jones SE, Delogu V, Kaliaraju D, et al. Pedometer step count targets during pulmonary rehabilitation in chronic obstructive pulmonary disease: a randomized controlled trial. American Journal of Respiratory and Critical Care Medicine 2017;195(10):1344‐52. - PMC - PubMed
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- Nolan CM, Maddocks M, Canavan JL, Jones SE, Delogu V, Kaliaraju D, et al. Pedometer step count targets during pulmonary rehabilitation in chronic obstructive pulmonary disease: a randomized controlled trial [abstract]. American Journal of Respiratory and Critical Care Medicine 2016;193:A7862. - PMC - PubMed
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- Nolan CM, Maddocks M, Canavan JL, Jones SE, Kon SS, Kaliaraju D, et al. Do pedometers maintain the benefits of pulmonary rehabilitation in COPD patients? [abstract]. European Respiratory Journal 2016;48:PA2058.
O'Neill 2018 {published data only}
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- O'Neill B, O'Shea OM, McDonough SM, McGarvey L, Bradbury I, Arden MA, et al. Physical activity intervention versus pulmonary rehabilitation in COPD: the LIVELY COPD project [abstract]. Thorax 2016;71(Suppl 3):A20. - PubMed
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- O’Neill B, O’Shea OM, McDonough SM, McGarvey L, Bradbury I, Arden MA, et al. Clinician‐facilitated physical activity intervention versus pulmonary rehabilitation for improving physical activity in COPD: a feasibility study. COPD: Journal of Chronic Obstructive Pulmonary Disease 2018;15(3):254‐64. - PubMed
Ogasawara 2018 {published data only}
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- Ogasawara T, Marui S, Miura E, Sugiura M, Matsuyama W, Aoshima Y, et al. Effect of eicosapentaenoic acid on prevention of lean body mass depletion in patients with exacerbation of chronic obstructive pulmonary disease: a prospective randomized controlled trial. Clinical Nutrition ESPEN 2018;28:67‐73. - PubMed
Orme 2018 {published data only}
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- Orme MW, Weedon AE, Esliger DW, Saukko PM, Morgan MD, Steiner MC, et al. Study protocol for Chronic Obstructive Pulmonary Disease‐Sitting and ExacerbAtions Trial (COPD‐SEAT): a randomised controlled feasibility trial of a home‐based self‐monitoring sedentary behaviour intervention [protocol]. BMJ Open 2016;6:e013014. - PMC - PubMed
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- Orme MW, Weedon AE, Saukko PM, Esliger DW, Morgan MD, Steiner MC, et al. Findings of the Chronic Obstructive Pulmonary Disease ‐ Sitting and Exacerbations Trial (COPD‐SEAT) in reducing time using wearable and mobile technologies with educational support: randomized controlled feasibility trial. JMIR mHealth and uHealth 2018;6(4):e84. - PMC - PubMed
Polkey 2018 {published data only}
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- Polkey MI, Qiu ZH, Zhou L, Zhu MD, Wu YX, Chen YY, et al. Tai Chi and pulmonary rehabilitation compared for treatment‐naïve patients with COPD; a randomized controlled trial. Chest 2018;153(3):1116‐24. - PubMed
Priori 2017 {published and unpublished data}
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- Priori R, Genugten L, Barretto C, Schonenberg H, Stut W, Miller B, et al. Automated coaching for physical activity in COPD patients: results from a pilot study [abstract]. European Respiratory Journal 2017;50:OA4868.
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- Saini PK, Dekker M, Van Genugten, Prior R, Klee M. Online coaching for physical activity in COPD patients: user engagement and determinants [abstract]. European Respiratory Journal 2018;52:PA3644.
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- Genugten L, Priori R, Barretto C, Schonenberg H, Dekker M, Klee M, et al. An online intervention to maintain physical activity levels in COPD patients after pulmonary rehabilitation [abstract]. Bulletin of the European Health Psychology Society 2016;18:635.
Probst 2011 {published data only}
-
- Probst VS, Kovelis D, Hernandes NA, Camillo CA, Cavalheri V, Pitta F. Effects of 2 exercise training programs on physical activity in daily life in patients with COPD. Respiratory Care 2011;56(11):1799‐807. - PubMed
Rinaldo 2017 {published data only}
-
- Rinaldo N, Bacchi E, Coratella G, Vitali F, Milanese C, Rossi A, et al. Effects of combined aerobic‐strength training vs fitness education program in COPD patients. International Journal of Sports Medicine 2017;38(13):1001‐8. - PubMed
Saini 2017 {published data only}
-
- Saini PK, Dekker M, Genugten L, Priori R, Klee M. Online coaching for physical activity in COPD patients: user engagement and determinants [abstract]. European Respiratory Journal 2018;52(Suppl 62):PA3644.
-
- Saini PK, Priori R, Barretto C, Delbressine J, Genugten L, Dekker M, et al. Activity maintenance after pulmonary rehabilitation ‐ first results of an online coaching program [abstract]. American Journal of Respiratory and Critical Care Medicine 2017;195:A4942.
-
- Genugten L, Prior R, Barretto C, Schonenberg H, Dekker M, Klee M, et al. An online intervention to maintain physical activity levels after pulmonary rehabilitation [abstract]. European Health Psychologist 2016; Vol. 18.
Sandland 2008 {published data only}
-
- Sandland CJ, Morgan MD, Singh SJ. Patterns of domestic activity and ambulatory oxygen usage in COPD. Chest 2008;134(4):753‐60. - PubMed
Schuz 2015 {published and unpublished data}
-
- Schuz N, Walters JA, Cameron‐Tucker H, Scott J, Wood‐Baker R, Walters EH. Patient anxiety and depression moderate the effects of increased self‐management knowledge on physical activity: a secondary analysis of a randomised controlled trail on health‐mentoring in COPD. Journal of Chronic Obstructive Pulmonary Disease 2015;12(5):502‐9. - PubMed
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- Walters JA, Cameron‐Tucker H, Wills K, Schuz N, Scott J, Robinson A, et al. Effects of telephone health mentoring in community‐recruited chronic obstructive pulmonary disease on self‐management capacity, quality of life and psychological morbidity: a randomised controlled trial. BMJ Open 2013;3(9):e003097. - PMC - PubMed
-
- Walters JA, Wills K, Robinson A, Nelson M, Scott J, Turner P, et al. Effect of health‐mentoring to increase daily physical activity in chronic obstructive pulmonary disease (COPD) [abstract]. Respirology 2012;17:TP079.
Sena 2013 {published and unpublished data}
-
- Sena R, Baril J, Kapchinsky S, MacMillan NJ, Rocha DV, Ruddy R, et al. The effects of eccentric and concentric exercise training on muscle strength in COPD: preliminary results [abstract]. European Respiratory Journal 2012;40(Suppl 56):P482.
-
- Sena R, MacMillan NJ, Baril J, Rocha V, Richard R, Perrault H, et al. Short term effects of eccentric and concentric exercise training on strength muscle, exercise capacity and physical activity in patients with chronic obstructive pulmonary disease [abstract]. Canadian Respiratory Journal 2013;20(2):e36.
Singh 1998 {published data only (unpublished sought but not used)}
-
- Singh SJ, Curcio A, Williams J, Morgan MD, Jones P. Does wearing an activity monitor influence daily activity recorded in patients with COPD? [abstract]. Thorax 1998;53(Suppl 4):A24.
Steele 2019 {published data only}
-
- Steele BG, Dougherty CM, Burr RL, Gylys‐Colwell I, Hunziker J. A feasibility trial of two rehabilitation models in severe cardiopulmonary illness. Rehabilitation Nursing 2019;44(3):130‐40. - PubMed
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- Steele BG, Dougherty CM, Burr RL, Gylys‐Colwell I, Hunziker J. An intervention to enhance function in severe cardiopulmonary illness [abstract]. American Journal of Respiratory and Critical Care Medicine 2012;185:A4879.
Tabak 2014a {published data only}
-
- Tabak M, Vollenbroek‐Hutten MM, Valk PD, Palen H, Hermens HJ. A telerehabilitation intervention for patients with chronic obstructive pulmonary disease: a randomized controlled pilot trial. Clinical Rehabilitation 2014;28(6):582‐91. - PubMed
Tabak 2014b {published data only}
Tahirah 2015 {published and unpublished data}
-
- Tahirah F, Jenkins S, Othman SK, Ismail R, Ismail T, Hill K. A randomised controlled trial of individualised, progressed early exercise in patients hospitalised with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) [abstract]. European Respiratory Journal 2015;46:PA743.
Troosters 2014 {published data only (unpublished sought but not used)}
-
- Sciurba FC, Siafakas NM, Troosters T, Klioze SS, Sutradhar SC, Weisman IM, et al. The efficacy and safety of tiotropium handihaler 18 micrograms once daily plus prn salbutamol versus placebo plus prn salbutamol in COPD subjects naive to maintenance therapy [abstract]. American Journal of Respiratory and Critical Care Medicine 2011;183:A1589.
Troosters 2018 {published data only}
-
- Bourbeau J, Sedeno M, Li PZ, Troosters T, Hamilton A, Sousa D, et al. Impact of meeting behavioral targets in a self‐management behaviour‐modification program designed to improve physical activity in COPD patients [abstract]. European Respiratory Journal 2017;50:PA4899.
-
- Frith P, Troosters T, Bourbeau J, Maltais F, Leidy N, Erzen D, et al. Effect of tiotropium and olodaterol, alone and with exercise training, on exercise endurance in COPD [abstract]. Respirology 2017;22(Suppl 2):TO048.
-
- Frith P, Troosters T, Lavoie KL, Leidy N, Maltais F, Sedeno M, et al. Bronchodilator therapy and exercise added to self‐management behaviour‐modifications: effects on physical activity in COPD [abstract]. Respirology 2017;22(Suppl 2):TO129.
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- Lavoie KL, Sedeno M, Li PZ, Troosters T, Hamilton A, Sousa D, et al. Effects of bronchodilator therapy and exercise with self‐management behaviour‐modification on psychological and cognitive outcomes in COPD [abstract]. European Respiratory Journal 2017;50:OA4669.
Tsai 2016 {published and unpublished data}
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- Tsai LL, McNamara RJ, Moddel C, Alison JA, McKenzie D, McKeogh ZJ. Home‐based telerehabilitation via real‐time videoconferencing improves endurance exercise capacity in patients with COPD: the randomized controlled TeleR study. Respirology 2017;22(4):699‐707. - PubMed
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- Tsai LL, McNamara RJ, Moddel C, Alison JA, McKenzie DK, McKeough ZJ. Home‐based telerehabilitation via real‐time videoconferencing improves endurance exercise capacity in patients with COPD: the randomized controlled TeleR sStudy [abstract]. Respirology 2016;21(S2):TP086. - PubMed
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- Tsai LL, McNamara RJ, Moddel C, McKenzie D, Alison JA, McKeough ZJ. Telerehabilitation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial [abstract]. European Respiratory Journal 2016;48(Suppl 60):PA2065.
Van de Bool 2017 {published data only}
-
- Beers M, Rutten‐van Molken MP, Bool C, Boland M, Kremers SP, Franssen FM, et al. Clinical outcome and cost‐effectiveness of 1‐year nutritional intervention program in COPD [abstract]. European Respiratory Journal 2018;52(Suppl 62):PA723.
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- Beers M, Rutten‐van Molken MP, Bool C, Boland M, Kremers SP, Franssen FM, et al. Clinical outcome and cost‐effectiveness of a 1‐year nutritional intervention programme in COPD patients with low muscle mass: the randomized controlled NUTRAIN trial. Clinical Nutrition 2019;39(2):405‐13. - PubMed
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- Bool C, Helvoort A, Franssen FM, Wouters EF, Schols AM. Physiological effects of nutritional supplementation as adjunct to exercise training in COPD patients with low muscle mass. The double blind, placebo controlled multi‐centre NUTRAIN‐trial [abstract]. European Respiratory Journal 2016;48(Suppl 60):OA266.
Varas 2018 {published and unpublished data}
-
- Varas AB, Cordoba S, Rodriguez‐Andonaegui I, Rueda MR, Garcia‐Juez S, Vilaro J. Effectiveness of a community‐based exercise training programme to increase physical activity level in patients with chronic obstructive pulmonary disease: a randomized controlled trial. Physiotherapy Research International 2018;23(4):e1740. - PubMed
Vasilopoulou 2017 {published and unpublished data}
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- Vasilopoulou M, Papaioannou AI, Chynkiamis N, Vasilogiannakopoulou T, Spetsioti S, Louvaris Z, et al. Effectiveness of home telerehabilitation on functional capacity and daily physical activity in COPD patients [abstract]. European Respiratory Journal 2015;46:OA273.
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- Vasilopoulou M, Papaioannou AI, Kaltsakas G, Louvaris Z, Chynkiamis N, Spetsioti S, et al. Home‐based maintenance tele‐rehabilitation reduces the risk of acute exacerbations of COPD, hospitalisations and emergency department visits. European Respiratory Journal 2017;49(5):pii:1602129. - PubMed
Vorrink 2016 {published data only}
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- Vorrink SN, Kort HS, Troosters T, Zanen P, Lammers JL. Efficacy of an mHealth intervention to stimulate physical activity in COPD patients after pulmonary rehabilitation. European Respiratory Journal 2016;48(4):1019‐29. - PubMed
Wan 2017 {published and unpublished data}
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- Wan ES, Kantorowski A, Homsy D, Kadri R, Richardson CR, Mori D, et al. Self‐reported task‐oriented physical activity: a comparison with objective daily step count in COPD. Respiratory Medicine 2018;140:63‐70. - PubMed
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- Wan ES, Kantorowski A, Teylan M, Kadri R, Richardson CR, Garshick E, et al. Patterns of change in daily step count among COPD patients enrolled in a 3‐month physical activity intervention [abstract]. American Journal of Respiratory and Critical Care Medicine 2017;195:A4939.
Watz 2016 {published and unpublished data}
-
- Watz H, Mailaender C, Kirsten AM. Effects of indacaterol/glycopyrronium on lung function and physical activity in patients with moderate to severe COPD [abstract]. Thorax 2015;70:A146‐7.
Watz 2017 {published data only}
-
- Watz H, Troosters T, Beeh KM, Garcia Aymerich J, Paggiaro P, Molins E, et al. ACTIVATE: effect of aclidinium/formoterol on physical activity in patients with COPD [abstract]. European Respiratory Journal 2017;60(Suppl 61):PA687.
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- Watz H, Troosters T, Beeh KM, Garcia Aymerich J, Paggiaro P, Molins E, et al. Effect of aclidinium/formoterol on lung hyperinflation, exercise capacity and physical activity in patients with COPD: results from ACTIVATE, a phase IV study [abstract]. American Journal of Respiratory and Critical Care Medicine 2017;195:A3593.
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- Watz H, Troosters T, Beeh KM, Garcia‐Aymerich J, Paggiaro P, Molins E, et al. ACTIVATE: the effect of aclidinium/formoterol on hyperinflation, exercise capacity and physical activity in patients with COPD. International Journal of Chronic Obstructive Pulmonary Disease 2017;12:2545‐58. - PMC - PubMed
Widyastuti 2018 {published data only}
-
- Widyastuti K, Makhabah DN, Rima A, Sutanto YS, Suradi S, Ambrosino N. Home based pulmonary rehabilitation with pedometers in Indonesian COPD patients [abstract]. European Respiratory Journal 2017;50:PA777.
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- Widyastuti K, Makhabah DN, Rima Setijadi A, Sutanto YS, Suradi S, Ambrosino N. Benefits and costs of home pedometer assisted physical activity in patients with COPD: a preliminary randomized controlled trial. Pulmonology 2018;24(4):211‐8. - PubMed
Wootton 2017 {published and unpublished data}
-
- Hill K, Wootton SL, Ng LW, Jenkins S, Cecins N, Straker L, et al. High‐intensity ground‐based walking does not change time spent in physical activity or sedentary behaviour in people with chronic obstructive pulmonary disease [abstract]. Respirology 2016;21(Suppl 2):TP083.
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- Watts SL, Ng LW, McKeogh ZJ, Jenkins S, Hill K, Eastwood PR, et al. Effects of ground walking training in COPD: a randomized controlled trial [abstract]. Respirology 2013;18(Suppl 2):O064.
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- Wootton SL, Hill K, Alison JA, Ng LW, Jenkins S, Eastwood PR, et al. Effects of ground‐based walking training on daily physical activity in people with COPD: a randomised controlled trial. Respiratory Medicine 2017;132:139‐45. - PubMed
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- Wootton SL, Hill K, Alison JA, Ng LW, Jenkins S, Eastwood PR, et al. Effects of ongoing feedback during a 12‐month maintenance walking program on daily physical activity in people with COPD. Lung 2019;197(3):315‐9. - PubMed
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- Wootton SL, Ng LW, McKeough ZJ, Jenkins S, Hill K, Eastwood PR, et al. Ground walking training in chronic obstructive pulmonary disease: a randomised controlled trial [abstract]. American Journal of Respiratory and Critical Care Medicine 2014;189:A4162.
References to studies excluded from this review
ACTRN12611001034921 {published data only}
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- ACTRN12611001034921. A randomised controlled clinical trial in adults with Chronic Obstructive Pulmonary Disease on the effect of telephone health‐mentoring, home‐based walking and rehabilitation compared with rehabilitation only on health‐related quality of life. www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=343303 (first received 29 November 2011).
Aksu 2006 {published data only}
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- Aksu B, Inanir M, Basyigit I, Dursun N, Yildiz F. Comparison of two different exercise programs in chronic obstructive pulmonary disease [abstract]. European Respiratory Journal 2006;28(Suppl 50):555s.
Arnedillo 1998 {published data only}
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- Arnedillo A, Puente L, Mangas A, Leaan A. Comparison of two exercise training programmes in patients with chronic obstructive pulmonary disease [abstract]. Neumosur 1998;10(4):223‐9.
Atkins 1984 {published data only}
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- Atkins CJ, Kaplan RM, Timms RM, Reinsch S, Lofback K. Behavioral exercise programs in the management of chronic obstructive pulmonary disease. Journal of Consulting and Clinical Psychology 1984;52(4):591‐603. - PubMed
Barnes‐Harris 2019 {published data only}
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- Barnes‐Harris M, Allgar V, Booth S, Currow D, Hart S, Phillips J, et al. Battery operated fan and chronic breathlessness: does it help?. BMJ Supportive and Palliative Care 2019;May 8:pii: bmjspcare‐2018‐001749. - PubMed
Bartlett 2017 {published data only}
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- Bartlett YK, Webb TL, Hawley MS. Using persuasive technology to increase physical activity in people with chronic obstructive pulmonary disease by encouraging regular walking: a mixed‐methods study exploring opinions and preferences. Journal of Medical Internet Research 2017;19(4):e124. - PMC - PubMed
Baumann 2006 {published data only}
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- Baumann HJ, Rummel K, Schmoller T, Meyer A. Efficacy of a long term ambulatory interdisciplinary rehabilitation (AIR) program in moderate to severe COPD [abstract]. European Respiratory Journal 2006;28(Suppl 50):555s.
Behnke 2000 {published data only}
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- Behnke M. The effects of a home‐based exercise training programme in patients with chronic obstructive lung disease. Pneumologie 2000;53:2‐3. - PubMed
Behnke 2005 {published data only}
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- Behnke M, Wewel AR, Kirsten D, Jorres RA, Magnussen H. Exercise training raises daily activity stronger than predicted from exercise capacity in patients with COPD. Respiratory Medicine 2005;99(6):711‐7. - PubMed
Bernardi 2017 {published data only}
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- Bernardi E, Merlo C, Bellotti F, Grazzi G, Cogo A. An exercise training program improves endothelial function in COPD patients [abstract]. European Respiratory Journal 2017;50(Suppl 61):OA1959.
Bertici 2013 {published data only}
Biscione 2009 {published data only}
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- Biscione G, Crigna G, Auciello L, Pasqua F, Cazzola M. Addition of tiotropium (T) to a regular treatment with long‐acting beta‐agonist + inhaled corticosteroid (LABA + ICS) in patients with severe to very‐severe COPD under in‐patient pulmonary rehabilitation program (PRP) [abstract]. European Respiratory Society 19th Annual Congress; 2009 Sep 12‐15; Vienna. 2009:P526.
Bohning 1990 {published data only}
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- Bohning W, Wettengel R. Physical exercise training in COPD during a 4 ‐week rehabilitation programme [abstract]. European Respiratory Journal 1990;3(Suppl 10):212S.
Boland 2015 {published data only}
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- Boland MR, Tsiachristas A, Rutten van Molken M. COPD performance indicators in an integrated care program and its impact on health outcomes: The Recode Cluster Randomized Trial [abstract]. Value in Health 2015;18(7):A505.
Börekçi 2008 {published data only}
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- Börekçi S, Elci A, Ovayolu N, Elbeck O. Applicability and efficacy of the pulmonary rehabilitation program for COPD patients in a secondary‐care community hospital [Abstract]. American Thoracic Society International Conference; 2008 May 16‐21; Toronto. 2008; Vol. 5, issue 5:P416.
Borges 2012 {published data only}
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- Borges RC, Carvalho CR. Physical activity in daily life in Brazilian COPD patients during and after exacerbation. Chronic Obstructive Pulmonary Disease 2012;9(6):596‐602. - PubMed
Bourbeau 2000 {published data only}
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- Bourbeau J, Julien M, Rouleau M, Maltais F, Beaupre A, Begin R, et al. Impact of an integrated rehabilitative self‐management program on health status of COPD patients: a multicentre randomised clinical trial [abstract]. European Respiratory Journal 2000;16(Suppl 31):159s.
Budnevskiy 2015 {published data only}
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- Budnevskiy AV, Chernov AV, Isaeva YV, Yu Malysh E. Clinical efficacy of pulmonary rehabilitation program in patients with chronic obstructive pulmonary disease and metabolic syndrome. Pulmonologiya 2015;25(4):447‐55.
Bunker 2012 {published data only}
Bustamante 2013 {published data only}
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- Bustamante V, Lopez de Santamaria E, Marina N, Gorostiza A, Fernandez Z, Galdiz J. Neuromuscular magnetic stimulation of the quadriceps muscle after COPD exacerbations. European Respiratory Journal 2013;42:P3572.
Camillo 2011 {published data only}
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- Camillo CA, Laburu V de M, Gonçalves NS, Cavalheri V, Tomasi FP, Hernandes NA, et al. Improvement of heart rate variability after exercise training and its predictors in COPD. Respiratory Medicine 2011;105(7):1054‐62. - PubMed
Cebollero 2018 {published data only}
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- Cebollero P, Anton M, Hernandez M, Hueto J. Walking program for COPD patients: clinical impact after two years of follow‐up [Programa de paseos para pacientes con EPOC: impacto clínico tras 2 anos de seguimiento]. Archivos de Bronconeumología 2018;54(8):431‐3. - PubMed
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- Hernandez Bonaga M, Zambom F, Cascante JA, Hueto J, Anton M, Cebollero Rivas P. Walking guide for COPD patients: a promoter of physical activity?. European Respiratory Journal 2014;44:p3681.
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- Hernandez M, Zambom F, Cascante JA, Hueto J, Anton M, Cebollero P. Walking guide for COPD patients: can be used as a promoter of physical activity?. European Respiratory Journal 2013;42:p3703.
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- Hernandez M, Zambom‐Ferraresi F, Milagros Anton M, Hueto J, Cascante J, Cebollero P. Short and long term effects of a physical activity programa in COPD patients. European Respiratory Journal 2015;46(Suppl 59):PA 2213.
Chen 2018 {published data only}
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- Chen K‐Y, Hung M‐H, Chang M‐C, Kuo C, Lin C‐M, Chuang L‐P, et al. Four‐weeks remote pulmonary rehabilitation protocol with mobile apps of real‐time heart rate monitoring for gold category B/C/D‐A study design. Respirology 2018;23(Suppl 2):82.
Corrado 1995 {published data only}
-
- Corrado A, Gorini M, Paola E, Martorana P, Villella G, Augustynen A, et al. Effects of a short outpatient pulmonary rehabilitation program (PRP) in severe COPD patients with chronic respiratory insufficiency (CRI) [abstract]. European Respiratory Journal 1995;8(Suppl 19):126s.
Coultas 2011 {published data only}
-
- Coultas D, Sloan J, Wilson D. Pilot study of effectiveness of home rehabilitation for homebound patients with severe COPD [abstract]. European Respiratory Society 21st Annual Congress; 2011 Sep 24‐28; Amsterdam. 2011:881s.
Coultas 2017 {published data only}
-
- Coultas D, Russo R, Peoples J, Ashmore J, Sloan J, Jackson B, et al. A lifestyle physical activity intervention is associated with decline in health care utilization (HCU) among patients with COPD [abstract]. European Respiratory Journal 2014;44(Suppl 58):P611.
De Backer 2014 {published data only}
-
- Backer W, Vos W, Holsbeke C, Vinchurkar S, Claes R, Hufkens A, et al. The effect of roflumilast in addition to LABA/LAMA/ICS treatment in COPD patients [abstract]. European Respiratory Journal 2014;44(2):527‐9. - PubMed
Deering 2011 {published data only}
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- Deering BM, Fullen B, Egan C, McCormack N, Kelly E, Pender M, et al. Acupuncture as an adjunct to pulmonary rehabilitation. Journal of Cardiopulmonary Rehabilitation and Prevention 2011;31(6):392‐9. - PubMed
De Souza 2017 {published data only}
-
- Souza Y, Sliva KM, Condesso D, Figueira B, Alves RR, Costa CH, et al. Home‐based pulmonary rehabilitation intervention: does it maintain the benefits achieved during the outpatient program [abstract]. American Journal of Respiratory and Critical Care Medicine 2017;195:A941.
Durheim 2015 {published data only}
-
- Durheim MT, Smith PJ, Babyak MA, Mabe SK, Emery CF, Blumenthal JA, et al. Physical function as measured by 6‐minute walk distance or accelerometry predicts clinical outcomes in COPD patients independent of GOLD 2011 [abstract]. American Journal of Respiratory and Critical Care Medicine 2014;189:A6679.
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- Durheim MT, Smith PJ, Babyak MA, Mabe SK, Martinu T, Welty‐Wolf KE, et al. Six‐minute‐walk distance and accelerometry predict outcomes in chronic obstructive pulmonary disease independent of Global Initiative for Chronic Obstructive Lung Disease 2011 Group. Annals of the American Thoracic Society 2015;12(3):349‐56. - PMC - PubMed
Dyer 2011 {published data only}
EUCTR2016‐003675‐21‐ES {published data only}
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- EUCTR2016‐003675‐21‐ES. A study to test different doses of Danirixin in patients with COPD. www.clinicaltrialsregister.eu/ctr‐search/trial/2016‐003675‐21/results (first received 18 April 2017).
Faulkner 2010 {published data only}
Fernandez 1998 {published data only}
-
- Fernandez J, Martin M, Moreno LF. Evaluation of a home‐based rehabilitation program controlled with pulse‐meter in COPD. Neumosur 1998;10(1):54‐5.
Foy 2006 {published data only}
-
- Foy CG, Wickley KL, Adair N, Lang W, Miller ME, Rejeski WJ, et al. The Reconditioning Exercise and Chronic Obstructive Pulmonary Disease Trial II (REACT II): Rationale and study design for a clinical trial of physical activity among individuals with chronic obstructive pulmonary disease. Contemporary Clinical Trials 2006;27(2):135‐46. - PubMed
Friis 2017 {published data only}
Furness 2014 {published data only}
Garcia Aymerich 2016 {published data only}
-
- Garcia Aymerich J, Puham M, Jongh C, Demeyer H, Erzen D, Gimeno Santos E, et al. Responsiveness of PROactive instruments to measure physical activity in COPD patients [abstract]. European Respiratory Journal 2016;48:PA1896.
Gohl 2004 {published data only}
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- Gohl O, Linz H, Otte B, Schonleben T, Weineck J, Worth H. Benefits of a multicomponent outpatient rehabilitation program for patients with chronic obstructive pulmonary disease [abstract]. American Thoracic Society 100th International conference; 2004 May 21‐26; Orlando. 2004:D14.
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- Gohl O, Linz H, Otte B, Schonleben T, Weineck J, Worth H. Effects of multicomponent outpatient rehabilitation program for patients with COPD [abstract]. European Respiratory Journal 2004;24(Suppl 48):208s.
Gohl 2006 {published data only}
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- Gohl O, Schacher C, Grensemann S, Worth H. Effects of inspiratory muscle training with the RESPIFIT S in addition to an outpatient exercise training program for patients with COPD [abstract]. European Respiratory Journal 2006;28(Suppl 50):556s.
Gomez 2006 {published data only}
Gosselink 1990 {published data only}
-
- Gosselink H, Keimpema A, Wagenaar R, Chadwick Straver R. The relative efficacy of a rehabilitation‐programme in COPD patients [abstract]. European Respiratory Journal 1990;10(Suppl 10):212S.
Grabenhorst 2013 {published data only}
-
- Grabenhorst M, Jehn M, Maldener N, Liebers U, Kohler F, Witt C. Telemedicine in patients with COPD: Feasibility and benefit of regular exercise testing via remote patient monitoring [abstract]. Pneumologie 2013;67:P377.
Greulich 2013 {published data only}
-
- Greulich T, Augsten M, Kehr K, Nell C, Koehler U, Werner J. A randomized clinical trial to assess the influence of a three months training program (individualized vs. non‐individualized) in patients with moderate to very severe COPD [abstract]. American Journal of Respiratory and Critical Care Medicine 2012;185:A4874.
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- Greulich T, Kehr K, Nell C, Haid D, Koehler U, Koehler K, et al. A randomized clinical trial comparing the influence of two different training modalities (individualized vs. non‐individualized) in patients with moderate to very severe COPD [abstract]. American Journal of Respiratory and Critical Care Medicine 2013;187:A1801.
Guell 2008 {published data only}
-
- Guell MR, Lucas P, Galdiz JB, Montemayor T, Gonzalez‐Moro JM, Gorostiza A, et al. Home versus hospital‐based pulmonary rehabilitation for patients with chronic obstructive pulmonary disease: a Spanish multicenter trial. Archivos de Bronconeumología 2008;44(10):512‐8. - PubMed
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- Guell R, Delucas P, Galdiz JB, Montemayor T, Rodriguez JM, Gorostiza A, et al. Effectiveness of a home based pulmonary rehabilitation program compared to a hospital based pulmonary rehabilitation program in COPD patients, a Spanish multicenter randomized trial [abstract]. European Respiratory Journal 2006;28(Supp 50):298s.
Gurgun 2011 {published data only}
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- Gurgun A, Tuncel S, Korkmaz Ekren P, Deniz PS, Karapolat H, Kayahan B. Efficacy of an eight‐week pulmonary rehabilitation in COPD patients: an experience of a single center in Turkey [abstract]. American Journal of Respiratory and Critical Care Medicine 2011;183:A5049.
Hartman 2012 {published data only}
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- Hartman JE, Boezen M, Heintzbergen S, Greef MH, Klooster K, Hacken NH, et al. Daily physical activity after bronchoscopic lung volume reduction: a pilot study. European Respiratory Journal 2012;40:1566‐7. - PubMed
Hataji 2017 {published data only}
Herrejon 2010 {published data only}
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- Herrejon A, Catalan P, Palop J, Inchaurraga I, Blanquer R, Lopez A, et al. Effect of 8‐week 320 mg Megestrol acetate daily administration In severe COPD and weight loss [abstract]. American Journal of Respiratory and Critical Care Medicine 2010;181:A4484.
Hillegass 2012 {published data only}
-
- Hillegass E, Hayes D, Sanders D, Owens T, Langbehn C, Johnson M, et al. Continuous versus pulsed oxygen: is there a difference with activity? A pilot study [abstract]. Chest 2012;142(4):802A.
Horton 2018 {published data only}
-
- Horton EJ, Mitchell KE, Johnson‐Warrington V, Apps LD, Sewell L, Morgan M, et al. Comparison of a structured home‐based rehabilitation programme withe conventional supervised pulmonary rehabilitation: a randomised non‐inferiority trial. Thorax 2018;73:29‐36. - PubMed
Ichinose 2017 {published data only}
-
- Ichinose M, Minakata Y, Motegi T, Ueki J, Gon Y, Seki T, et al. Efficacy of tiotropium/olodaterol on lung hyperinflation, exercise capacity, and physical activity in Japanese patients with Chronic Obstructive Pulmonary Disease (VESUTO Study): a randomized crossover trial [abstract]. American Journal of Respiratory and Critical Care Medicine 2018;197:A4243.
-
- Ichinose M, Minakata Y, Motegi T, Ueki J, Seki T, Anzai T, et al. Study design of VESUTO: efficacy of tiotropium/olodaterol on lung hyperinflation, exercise capacity and physical activity in Japanese patients with chronic obstructive pulmonary disease. Advances in Therapy 2017;34(7):1622‐35. - PMC - PubMed
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- Ichinose M, Minakata Y, Motegi T, Ueki J, Seki T, Anzai T, et al. Study design of VESUTO; study to evaluate the efficacy of tiotropium + olodaterol vs tiotropium on lung hyperinflation, exercise capacity, and physical activity in Japanese COPD patients [abstract]. Respirology 2016;21(S3):APSR6‐0457.
-
- Minakata Y, Motegi T, Ueki J, Gon Y, Seki T, Anzai T, et al. Efficacy of tiotropium/olodaterol on sedentary/active time in COPD patients: VESUTO study [abstract]. European Respiratory Journal 2018;52(Suppl 62):PA4390.
Ides 2012 {published data only}
-
- Ides KM, Backer L, Daems D, Boelen E, Leemans G, Vissers D, et al. Preliminary results of noninvasive ventilation during a pulmonary rehabilitation program in patients with COPD [abstract]. European Respiratory Journal 2012;50(Suppl 56):639s.
Innocenti 2000 {published data only}
-
- Innocenti F, Fabbri A, Guerrini M, Fonseca D, Lippi P. Results of an outpatient pulmonary rehabilitation program in patients with COPD [abstract]. European Respiratory Journal 2000;16(Suppl 31):46s.
Johnson‐Warrington 2016 {published data only}
Jonsdottir 2015 {published data only}
-
- Jonsdottir H, Amundadottir OR, Gudmundsson G, Halldorsdottir BS, Hrafnkelsson B, Ingadottir TS, et al. Effectiveness of a partnership‐based self‐management programme for patients with mild and moderate chronic obstructive pulmonary disease: a pragmatic randomized controlled trial. Journal of Advanced Nursing 2015;71(11):2634‐49. - PubMed
Kato 2017 {published data only}
Kim 2003 {published data only}
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- Kim DS, Na JO, Jegal YJ, Yoon SH, Shim TS, Lim CM, et al. Efficacy of home based pulmonary rehabilitation program for the patients with chronic lung diseases [abstract]. European Respiratory Journal 2003;22(Suppl 45):A1082.
Kruis 2014 {published data only}
Langer 2018 {published data only}
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Larraz 2010 {published data only}
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Lee 2007 {published data only}
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- Lee KH, Shin KC, Chung JH, Yu SK. Effects of self‐efficacy promoting pulmonary rehabilitation program for chronic obstructive pulmonary disease patients [abstract]. American Thoracic Society International Conference; 2007 May 18‐23; San Francisco. 2007:M60.
Liang 2018 {published data only}
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Liu 2019 {published data only}
Lum 2007 {published data only}
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- Lum CM, Woo J, Yeung F, Hui DS, Hui E. Semi‐supervised, domiciliary pulmonary rehabilitation programme: a controlled clinical trial. Hong Kong Medical Journal 2007;13(Suppl 5):42‐5.
Mahesh 2017 {published data only}
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Marques 2019 {published data only}
Martinez 2008 {published data only}
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McGlone 2006 {published data only}
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Mesquita 2017 {published data only}
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Moore 2009 {published data only}
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Morris 2012 {published data only}
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- Morris NR, Atkinson C, Seale H, Walsh J. The addition of a pedometer guided intervention to pulmonary rehabilitation [abstract]. American Journal of Respiratory and Critical Care Medicine 2012;185:A2383.
Moy 2009 {published data only}
Moy 2012 {published data only}
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Murphy 2005 {published data only}
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Nagata 2018 {published data only}
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NCT01012765 {published data only}
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NCT01380652 {published data only}
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- NCT01380652. Effects of whole body vibration training on physical activity in Chronic Obstructive Pulmonary Disease (COPD) III/IV patients during a three‐week rehabilitation. clinicaltrials.gov/ct2/show/NCT01380652 (first received 27 June 2011).
NCT01486186 {published data only}
NCT01722370 {published data only}
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- NCT01722370. Ambulatory oxygen effects on muscles in COPD (OM‐COPD). clinicaltrials.gov/ct2/show/NCT01722370 (first received 6 November 2012).
NCT01854008 {published data only}
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NCT01867970 {published data only}
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- Verwey R, Weegen S, Spreeuwenberg M, Tange H, Weijden T, Witte L. A monitoring and feedback tool embedded in a counselling protocol to increase physical activity of patients with COPD or type 2 diabetes in primary care: study protocol of a three‐arm cluster randomised controlled trial. BMC Family Practice 2014;15:93. - PMC - PubMed
NCT01871025 {published data only}
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NCT02100709 {published data only}
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- NCT02100709. The effect of NIV on QoL and exercise capacity in a COPD exercise rehabilitation program. clinicaltrials.gov/ct2/show/NCT02100709 (first received 27 March 2014).
NCT02172794 {published data only}
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- NCT02172794. Tiotropium inhalation capsules and salmeterol inhalation aerosol on muscular efficiency and resting energy expenditure in patients with stable chronic obstructive pulmonary disease. clinicaltrials.gov/ct2/show/NCT02172794 (first received 24 June 2014).
NCT02629965 {published data only}
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- NCT02629965. Comparing the efficacy of tiotropium + olodaterol fixed dose combination over tiotropium in improvement of lung hyperinflation, exercise capacity and physical activity in Japanese COPD patients. clinicaltrials.gov/ct2/show/NCT02629965 (first received 15 December 2015).
NCT02656667 {published data only}
NCT03751670 {published data only}
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- NCT03751670. Pulmonary rehabilitation during acute exacerbations of Chronic Obstructive Pulmonary Disease: a mixed‐methods approach. clinicaltrials.gov/ct2/show/NCT03751670 (first received 23 November 2018).
NL1729 {published data only}
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Norweg 2006 {published data only}
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Nyberg 2017 {published data only}
Paneroni 2016 {published data only}
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- Paneroni M, Scalvini S, Bernocchi P, Galli T, Baratti D, Rovere MT, et al. Home telerehabilitation maintenance program for patients affected by COPD and CHF [abstract]. European Respiratory Journal 2016;48(Suppl 60):OA268.
Pasqua 2010 {published data only}
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- Pasqua F, Biscione G, Crigna G, Auciello L, Cazzola M. Combining triple therapy and pulmonary rehabilitation in patients with advanced COPD: A pilot study. Respiratory Medicine 2010;104(3):412‐7. - PubMed
Pinnock 2013 {published data only}
Pitta 2008 {published data only}
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- Pitta F, Takaki MY, Oliveira NH, Sant'anna TJ, Fontana AD, Kovelis D, et al. Relationship between pulmonary function and physical activity in daily life in patients with COPD. Respiratory Medicine 2008;102(8):1203‐7. - PubMed
Pomidori 2012 {published data only}
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- Pomidori L, Contoli M, Mandolesi G, Cogo A. A simple method for home exercise training in patients with chronic obstructive pulmonary disease: One‐year study. Journal of Cardiopulmonary Rehabilitation and Prevention 2012;32(1):53‐7. - PubMed
Raphael 2014 {published data only}
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- Raphael Y, Maynard Da Silva K, Bessa EJ, Bartholo TP, Faria AC, Noronha Filho AJ, et al. Brazilian manual of home‐based pulmonary rehabilitation: does it maintain the benefits achieved during the outpatient program? [abstract]. American Journal of Respiratory and Critical Care Medicine 2014;189:A1913.
Ringbaek 2009 {published data only}
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- Ringbaek T, Broendum E, Martinez G, Thoegersen J, Lange P. Effect of maintenance training after 7‐weeks rehabilitation programme on hospitalisation [abstract]. European Respiratory Society 19th Annual Congress; 2009 Sep 12‐15; Vienna. 2009:P576.
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Roman 2013 {published data only}
Schacher 2006 {published data only}
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Sewell 2005 {published data only}
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Sewell 2010 {published data only}
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- Sewell L, Singh SJ, Williams JE, Morgan MD. Seasonal variations affect physical activity and pulmonary rehabilitation outcomes. Journal of Cardiopulmonary Rehabilitation and Prevention 2010;30(5):329‐33. - PubMed
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- Soicher JE. A longitudinal study of physical activity behaviour in chronic disease: the example of chronic obstructive pulmonary disease [dissertation]. Montreal: McGill University, Montreal, 2009.
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U1111‐1169‐0718 {published data only}
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Wilson 2015 {published data only}
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References to ongoing studies
ACTRN12615000121561 {published data only}
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- ACTRN12615000121561. Effect of opioids on outcomes of pulmonary rehabilitation. www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=367581 (first received 12 January 2015).
ACTRN 12616000360415 {published data only}
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ACTRN12617000242325 {published data only}
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- ACTRN12617000242325. Tai Chi for people with chronic obstructive pulmonary disease (COPD). www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372216 (first received 16 February 2017).
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- ACTRN12617000499381. Non drug interventions to reduce breathlessness in patients with chronic obstructive pulmonary disease (emphysema). www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372467 (first received 6 April 2017).
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EUCTR2013‐003619‐24‐ES {published data only}
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- EUCTR2016‐001238‐89‐ES. Impact of iron replacement in patients with chronic obstructive pulmonary disease. www.clinicaltrialsregister.eu/ctr‐search/trial/2016‐001238‐89/ES (first received 20 April 2016).
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- EUCTR2016‐001805‐18‐SE. A pilot study to explore safety and efficacy of NBMI treatment compared to placebo in patients with chronic obstructive pulmonary disease. www.clinicaltrialsregister.eu/ctr‐search/trial/2016‐001805‐18/SE (first received 19 May 2016).
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- Fastenau A. Exercise training and physical activity in patients with mild to moderate COPD in primary care [thesis]. Maastricht: Maastricht University, Maastricht, 2015.
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- ISRCTN13899108. Can a physical activity programme or pulmonary rehabilitation reduce the risk of heart and circulation disease in people with COPD?. www.isrctn.com/ISRCTN13899108 (first received 5 April 2019).
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- ISRCTN15949009. Humidified nasal high flow to improve clinical outcomes following severe exacerbations of chronic obstructive pulmonary disease. www.isrctn.com/ISRCTN15949009 (first received 19 February 2019).
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- ISRCTN17942821. A self‐management programme of activity coping and education ‐ SPACE FOR COPD ‐ in primary care: a pragmatic trial. www.isrctn.com/ISRCTN17942821?q=&filters=conditionCategory:Respirato... (first received 17 November 2014).
ISRCTN19684749 {published data only}
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- ISRCTN19684749. CELEB: Lung volume reduction in COPD ‐ surgery vs endobronchial valves. www.isrctn.com/ISRCTN19684749?q=&filters=conditionCategory:Respirato... (first received 23 May 2016).
ISRCTN27860457 {published data only}
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- ISRCTN27860457. ON‐EPIC Oral nitrate supplementation to enhance pulmonary rehabilitation in chronic obstructive pulmonary disease. www.isrctn.com/ISRCTN27860457 (first received 22 September 2014).
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- Pavitt M, Lewis AP, Buttery SC, Fernandez BO, Mikus‐Lelinska M, Feelisch M, et al. Dietary nitrate supplementation increases exercise endurance time in COPD patients using ambulatory oxygen [abstract]. European Respiratory Journal 2018;52(Suppl 62):PA4049.
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- Pavitt M, Tanner RJ, Lewis AP, Buttery SC, Mehta B, Jefford H, et al. Dietary nitrate supplementation enhances the benefit of pulmonary rehabilitation in people with COPD [abstract]. European Respiratory Journal 2018;52(Suppl 62):PA4045.
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- Pavitt MJ, Tanner RJ, Lewis AP, Buttery SC, Mehta B, Jefford H, et al. Oral dietary nitrate supplementation to enhance pulmonary rehabilitation in chronic obstructive pulmonary disease: a multi‐centre, double blind, placebo‐controlled, parallel group study [abstract]. Thorax 2018;73(Suppl 4):A3. - PubMed
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- ISRCTN45695543. Training to improve dyspnoea. www.isrctn.com/ISRCTN45695543 (first received 15 February 2017).
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- ISRCTN80279999. Domiciliary application of non‐invasive positive pressure ventilation with average volume assured pressure support to subjects with chronic obstructive pulmonary disease (COPD) who remain hypercapnic following the application of non‐invasive positive pressure ventilation (NPPV) for an acute exacerbation. www.isrctn.com/ISRCTN80279999 (first received 11 December 2008).
NCT01037387 {published data only}
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- NCT01037387. Effect of noninvasive ventilation on physical activity and inflammation in COPD patients. clinicaltrials.gov/ct2/show/NCT01037387 (first received 23 December 2009).
NCT01537627 {published data only}
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- NCT01537627. Long‐term physical training in chronic obstructive pulmonary disease. clinicaltrials.gov/ct2/show/NCT01537627 (first received 23 February 2012).
NCT01539434 {published data only}
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NCT01783808 {published data only}
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- NCT01783808. Intervention study to investigate supplemental oxygen in COPD. clinicaltrials.gov/ct2/show/NCT01783808 (first received 5 February 2013).
NCT01905982 {published data only}
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- NCT01905982. The effect of reflective breathing therapy compared with conventional breathing therapy in patients with chronic obstructive pulmonary disease (COPD) III‐IV; part 2. clinicaltrials.gov/ct2/show/NCT01905982 (first received 23 July 2013).
NCT01998724 {published data only}
NCT02099799 {published data only}
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- NCT02099799. The effect of physical activity promotion on short and long‐term outcomes in COPD (WEB). clinicaltrials.gov/ct2/show/NCT02099799 (first received 31 March 2014).
NCT02205242 {published data only}
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- NCT02205242. BACE trial substudy 1 ‐ PROactive substudy. clinicaltrials.gov/ct2/show/NCT02205242 (first received 31 July 2014).
NCT02398643 {published data only}
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- NCT02398643. Examine the impact of early education on COPD management. clinicaltrials.gov/ct2/show/NCT02398643 (first received 25 March 2015).
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NCT02667171 {published data only}
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NCT02691104 {published data only}
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NCT02702791 {published data only}
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NCT02707770 {published data only}
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- NCT02707770. The role of ambulatory oxygen in improving the effectiveness of pulmonary rehabilitation for COPD patients. clinicaltrials.gov/ct2/show/NCT02707770 (first received 14 March 2016).
NCT02720822 {published data only}
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- Currow D, Watts GJ, Johnson M, McDonald CF, Miners JO, Somogyi AA, et al. on behalf of the Australian National Palliative Care Clinical Studies Collaborative. A pragmatic, phase III, multisite, double‐blind, placebo‐controlled, parallel‐arm, dose increment randomised trial of regular, low‐dose extended‐release morphine for chronic breathlessness: breathlessness, exertion And morphine sulfate (BEAMS) study protocol. BMJ Open 2017;7(7):e018100. - PMC - PubMed
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NCT02864420 {published data only}
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NCT02895152 {published data only}
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- NCT02895152. Activity monitor use in COPD patients undergoing rehabilitation. clinicaltrials.gov/ct2/show/NCT02895152 (first received 9 September 2016).
NCT02917915 {published data only}
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- NCT02917915. The CaNadian Standardized Pulmonary Rehabilitation Efficacy trial (CoNSPiRE). clinicaltrials.gov/ct2/show/NCT02917915 (first received 28 September 2016).
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NCT02956213 {published data only}
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- NCT02956213. Indoor air quality and respiratory symptoms in former smokers. clinicaltrials.gov/ct2/show/NCT02956213 (first received 6 November 2016).
NCT02966561 {published data only}
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- Geidl W, Semrau J, Streber R, Lehbert N, Wingart S, Tallner A, et al. Effects of a brief, pedometer‐based behavioral intervention for individuals with COPD during inpatient pulmonary rehabilitation on 6‐week and 6‐month objectively measured physical activity: study protocol for a randomized controlled trial. Trials 2017;18:396. - PMC - PubMed
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NCT02999685 {published data only}
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NCT03073954 {published data only}
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- NCT03073954. Working memory training in COPD patients: the Cogtrain‐Trial. clinicaltrials.gov/ct2/show/NCT03073954 (first received 8 March 2017).
NCT03080662 {published data only}
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- NCT03080662. Impact of inspiratory muscle training on daily physical activity (INAF). clinicaltrials.gov/ct2/show/NCT03080662 (first received 15 March 2017).
NCT03084874 {published data only}
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- NCT03084874. Efficacy of a coaching program to promote physical activity and reduce sedentary behavior after a COPD hospitalization. clinicaltrials.gov/ct2/show/NCT03084874 (first received 21 March 2017).
NCT03114241 {published data only}
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- NCT03114241. Long‐term effects of a 3‐month pedometer‐based program to enhance physical activity in patients with severe COPD. clinicaltrials.gov/ct2/show/NCT03114241 (first received 14 April 2017).
NCT03127878 {published data only}
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- NCT03127878. Effects of upper‐limb training addition to a conventional ET program on PA level and ADL performance. clinicaltrials.gov/ct2/show/NCT03127878 (first received 25 April 2017).
NCT03201198 {published data only}
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- NCT03201198. Active for life: chronic obstructive pulmonary disease (ActiveCOPD). clinicaltrials.gov/ct2/show/NCT03201198 (first received 28 June 2017).
NCT03275116 {published data only}
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- NCT03275116. The effect of twice daily vs. once daily bronchodilation on hyperinflation in COPD patients during 24 hours (BOTH). clinicaltrials.gov/ct2/show/NCT03275116 (first received 7 September 2017).
NCT03280355 {published data only}
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- NCT03280355. The effects of singing training for patients with chronic obstructive pulmonary disease. clinicaltrials.gov/ct2/show/NCT03280355 (first received 12 September 2017).
NCT03321279 {published data only}
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- NCT03321279. Social incentives to increase mobility. clinicaltrials.gov/ct2/show/NCT03321279 (first received 25 October 2017).
NCT03359473 {published data only}
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- NCT03359473. Study to evaluate the safety and efficacy of 13 weeks of the selective androgen receptor modulator (SARM) GSK2881078 in chronic obstructive pulmonary disease. clinicaltrials.gov/ct2/show/NCT03359473 (first received 2 December 2017).
NCT03513068 {published data only}
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- NCT03513068. Portable oxygen concentrator improvements to physical activity, oxygen usage, and quality of life in chronic obstructive pulmonary disease patients using long‐term oxygen therapy (POC‐STEP). clinicaltrials.gov/ct2/show/NCT03513068 (first received 1 May 2018).
NCT03584269 {published data only}
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- NCT03584269. Innovation in non invasive ventilation in COPD patients treated by long term oxygen therapy (INOV‐LTOT). clinicaltrials.gov/ct2/show/NCT03584269 (first received 12 July 2018).
NCT03584295 {published data only}
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- NCT03584295. Early extubation by ECCO2R compared to IMV in patients with severe acute exacerbation of COPD (X‐COPD). clinicaltrials.gov/ct2/show/NCT03584269 (first received 12 July 2018).
NCT03620630 {published data only}
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- NCT03620630. Clinical efficacy and cost effectiveness of MYCOPD in patients with mild and moderate newly diagnosed COPD (EARLY). clinicaltrials.gov/ct2/show/NCT03620630 (first received 8 August 2018).
NCT03654092 {published data only}
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- Frei A, Radtke T, Lana KD, Braun J, Müller RM, Puhan MA. Effects of a long‐term home‐based exercise training programme using minimal equipment vs. usual care in COPD patients: a study protocol for two multicentre randomised controlled trials (HOMEX‐1 and HOMEX‐2 trials). BMC Pulmonary Medicine 2019;19:57. - PMC - PubMed
NCT03655028 {published data only}
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- NCT03655028. Increasing physical activity in COPD through rhythmically enhanced music. clinicaltrials.gov/ct2/show/NCT03655028 (first received 31 August 2018).
NCT03660644 {published data only}
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- NCT03660644. Physical activity following pulmonary rehabilitation in COPD. clinicaltrials.gov/ct2/show/NCT03660644 (first received 6 September 2018).
NCT03746873 {published data only}
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- NCT03746873. Increase level of physical activity and decrease use of health care for people with COPD. clinicaltrials.gov/ct2/show/NCT03746873 (first received 20 November 2018).
NCT03749655 {published data only}
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- NCT03749655. Physical activity promotion added to standard care pulmonary rehabilitation and cognitive behavioural therapy. clinicaltrials.gov/ct2/show/NCT03749655 (first received 21 November 2018).
NCT03750292 {published data only}
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- NCT03750292. Residential cleaning of indoor air to protect COPD patients (CARE). clinicaltrials.gov/ct2/show/NCT03750292 (first received 23 November 2018).
NCT03793192 {published data only}
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- NCT03793192. Promoting activity after COPD exacerbations (aim 2, PACE2). clinicaltrials.gov/ct2/show/NCT03793192 (first received 4 January 2019).
NCT03794921 {published data only}
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- NCT03794921. COPD access to pulmonary rehabilitation intervention (CAPRI). clinicaltrials.gov/ct2/show/NCT03794921 (first received 7 January 2019).
NCT03807310 {published data only}
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- NCT03807310. Targeted nutrient supplement in COPD (NUTRECOVER‐trial). clinicaltrials.gov/ct2/show/NCT03807310 (first received 16 January 2019).
NCT03810755 {published data only}
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- NCT03810755. EfiKroniK research program: physical exercise for people with chronic pathologies. clinicaltrials.gov/ct2/show/NCT03810755 (first received 22 January 2019).
NCT03817294 {published data only}
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- NCT03817294. Personalised exercise training in COPD. clinicaltrials.gov/ct2/show/NCT03817294 (first received 25 January 2019).
NCT03869112 {published data only}
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- NCT03869112. Physical activity intervention and cardiovascular risk markers in COPD (PARC). clinicaltrials.gov/ct2/show/NCT03869112 (first received 11 March 2019).
NCT03899558 {published data only}
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- NCT03899558. The role of HNHF to improve clinical outcomes following severe AECOPD. clinicaltrials.gov/ct2/show/NCT03899558 (first received 2 April 2019).
NL3827 {published data only}
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- NL3827. Pulmonary rehabilitation of COPD: a trial of sustained internet based self‐management support (PRACTISS COPD). www.trialregister.nl/trial/3827 (first received 27 May 2013).
NL5277 {published data only}
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- NL5277. Efficacy of a physical activity coaching system for patients with COPD. www.trialregister.nl/trial/5277 (first received 30 October 2015).
RBR‐3zmh3r {published data only}
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- RBR‐3zmh3r. Effects of the inclusion of a functional circuit to aerobic and resistance training on functionality, physical activity in daily life and inflammation of patients with chronic obstructive pulmonary disease. www.ensaiosclinicos.gov.br/rg/RBR‐3zmh3r/ (first received 7 March 2018).
UMIN000027190 {published data only}
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- UMIN000027190. The effect of the combination treatment with tiotropium and olodaterol compared to tiotropium on symptoms, respiratory functions and physical activity in maintenance naive Japanese patient with COPD. upload.umin.ac.jp/cgi‐open‐bin/ctr_e/ctr_view.cgi?recptno=R000031159 (first received 29 April 2017).
UMIN000031173 {published data only}
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- UMIN000031173. Combined effect of progressive resistance training and physical activity counseling in patients with chronic obstructive pulmonary disease: a randomized controlled crossover study. upload.umin.ac.jp/cgi‐open‐bin/ctr_e/ctr_view.cgi?recptno=R000035589 (first received 26 February 2018).
UMIN000033093 {published data only}
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- UMIN000033093. The effect of comprehensive respiratory rehabilitation using cloud system on exacerbation of patients with chronic obstructive pulmonary disease at home. upload.umin.ac.jp/cgi‐open‐bin/ctr_e/ctr_view.cgi?recptno=R000037694 (first received 1 July 2018).
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