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. 2020 May 1;45(3):222-223.
doi: 10.1503/jpn.200061. Epub 2020 Apr 3.

Consensus statement on the use of clozapine during the COVID-19 pandemic

Affiliations

Consensus statement on the use of clozapine during the COVID-19 pandemic

Dan Siskind et al. J Psychiatry Neurosci. .
No abstract available

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Conflict of interest statement

W. Honer has received consulting fees or sat on paid advisory boards for the Canadian Agency for Drugs and Technology in Health, AlphaSights, Guidepoint, In Silico, Translational Life Sciences, Otsuka, Lundbeck and Newron. S. Clark has recieved an investigator-initated grant, participated in an advisory and an educational board and recieved speakers fees from Lundbeck-Otsuka Australia and received an investigator-initiated grant from Janssen-Cilag Australia. He has received speakers fees from Servier Australia. C. Correll has been a consultant and/or advisor to or has received honoraria from Acadia, Alkermes, Allergan, Angelini, Axsome, Gedeon Richter, Gerson Lehrman Group, IntraCellular Therapies, Janssen/J&J, LB Pharma, Lundbeck, MedAvante-ProPhase, Medscape, Neurocrine, Noven, Otsuka, Pfizer, Recordati, Rovi, Sumitomo Dainippon, Sunovion, Supernus, Takeda and Teva. He has provided expert testimony for Janssen and Otsuka. He served on a data safety monitoring board for Lundbeck, Rovi, Supernus and Teva. He has received grant support from the Berlin Institute of health, Janssen, the National Institute of Mental Health, Patient Centered Outcomes Research Institute, Takeda and the Thrasher Foundation. He has received royalties from UpToDate and is a stock option holder of LB Pharma. A. Hasan has been on the advisory boards and has received speaker fees from Janssen, Lundbeck and Otsuka. O. Howes reports receiving speaker fees, participating on advisory boards, and/or receiving investigator-initiated funding from manufacturers of antipsychotics, including clozapine. J. Kane declares consulting fees/honoraria from Acadia, Alkermes, Allergan, Eli Lilly, Forum, Genentech, Dainippon Sumitomo, H. Lundbeck, Intracellular Therapies, Janssen Pharmaceutical, Jazz Pharma, Johnson & Johnson, LB Pharmaceuticals, Merck, Minerva, Neurocrine, Otsuka, Pierre Fabre, Reviva, Roche, Sunovion, Takeda and Teva, as well as grant support from Otsuka, Lundbeck and Janssen. He is also a shareholder in Vanguard Research Group and LB Pharmaceuticals, Inc. D. Kelly has served as a consultant for Lundbeck, HLS Therapeutics and Alkermes, and is a joint holder of a patent for analytical microdevices for mental health treatment monitoring (US9581536B2). J. MacCabe has received research grants from, and acted as an unpaid consultant to Lundbeck and Saladax Biomedical. D. Taylor has received research funding from Janssen and Sunovion and lecture payments form Janssen, Lundbeck, Otsuka and Recordati. O. Freudenreich has received a grant from Avanir for a clinical trial involving patients taking clozapine and royalties from UpToDate for the entry on clozapine. No other authors declared competing interests.

Comment in

  • Clozapine and COVID-19.
    Remington G, Powell V. Remington G, et al. J Psychiatry Neurosci. 2020 Jul 1;45(4):E1. doi: 10.1503/jpn.2045301. J Psychiatry Neurosci. 2020. PMID: 32584527 Free PMC article. No abstract available.
  • Clozapine toxicity and coronavirus disease 2019: A case report.
    Sagué-Vilavella M, López-Pelayo H, Arbelo N, Cámara M, Gomes S, Madero S, Pons-Cabrera MT, Pintor L. Sagué-Vilavella M, et al. Schizophr Res. 2022 Feb;240:184-185. doi: 10.1016/j.schres.2022.01.008. Epub 2022 Jan 10. Schizophr Res. 2022. PMID: 35030448 Free PMC article. No abstract available.

References

    1. Siskind D, McCartney L, Goldschlager R, et al. Clozapine v. first-and second-generation antipsychotics in treatment-refractory schizophrenia: systematic review and meta-analysis. Br J Psychiatry. 2016;209:385–92. - PubMed
    1. Land R, Siskind D, McArdle P, et al. The impact of clozapine on hospital use: a systematic review and meta-analysis. Acta Psychiatr Scand. 2017;135:296–309. - PubMed
    1. Vermeulen JM, van Rooijen G, Van de Kerkhof MPJ, et al. Clozapine and long-term mortality risk in patients with schizophrenia: a systematic review and meta-analysis of studies lasting 1.1–12.5 years. Schizophr Bull. 2019;45:315–29. - PMC - PubMed
    1. Myles N, Myles H, Xia S, et al. Meta-analysis examining the epidemiology of clozapine-associated neutropenia. Acta Psychiatr Scand. 2018;138:101–9. - PubMed
    1. Nielsen J, Young C, Ifteni P, et al. Worldwide differences in regulations of clozapine use. CNS Drugs. 2016;30:149–61. - PubMed

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