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Comment
. 2020 Jul;45(7):551-553.
doi: 10.1016/j.tibs.2020.03.012. Epub 2020 Apr 13.

γδ TCR Recognition of MR1: Adapting to Life on the Flip Side

Benjamin E Willcox  1 , Fiyaz Mohammed  2 , Carrie R Willcox  2
Affiliations
Comment

γδ TCR Recognition of MR1: Adapting to Life on the Flip Side

Benjamin E Willcox et al. Trends Biochem Sci. 2020 Jul.

Abstract

Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations. Recently, Le Nours et al. identified human γδ T cells recognising MHC-related protein-1 (MR1) via their T cell receptor (TCR). Also recognised by the αβ-TCR of mucosal associated invariant T cells, MR1 interacts with specific γδ-TCRs using strikingly diverse binding modes, suggesting fundamental differences in γδ T cell recognition.

Keywords: T cell receptor (TCR); complementarity determining region (CDR); gamma delta; major histocompatibility complex (MHC).

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Figures

Figure 1
Figure 1
Overview of the MAIT αβ TCR-MR1-5-OP-RU, G7 γδ TCR-MR1-5-OP-RU, and CD8αα-HLA-A2 Complexes. (A) Cartoon representation of the MAIT αβ TCR-MR1-5-OP-RU complex (PDB ID: 4NQC): MR1, brown; β2-microglobulin (β2M), blue; 5-OP-RU, green; α-chain, light green; β-chain, cyan. (B) Cartoon representation of the G7 γδ TCR-MR1-5-OP-RU complex (PDB ID: 6MWR): MR1, brown; β2M, blue; 5-OP-RU, green; Vγ9 chain, pale cyan; Vδ1 chain, salmon. (C) Cartoon representation of the CD8αα-HLA-A2 complex (PDB ID: 1AKJ): HLA-A2, orange; β2M, blue; peptide, hot pink; CD8αα, red and yellow. Ig-like variable and constant domains for α, β, γ, and δ chains are indicated by Vα, Cα, Vβ, Cβ, Vγ, Cγ, and Vδ, Cδ respectively. Abbreviations: MAIT, mucosa associated invariant T cell; MR1, MHC-related protein 1; TCR, T cell receptor.
See this image and copyright information in PMC

Comment on

  • A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.
    Le Nours J, Gherardin NA, Ramarathinam SH, Awad W, Wiede F, Gully BS, Khandokar Y, Praveena T, Wubben JM, Sandow JJ, Webb AI, von Borstel A, Rice MT, Redmond SJ, Seneviratna R, Sandoval-Romero ML, Li S, Souter MNT, Eckle SBG, Corbett AJ, Reid HH, Liu L, Fairlie DP, Giles EM, Westall GP, Tothill RW, Davey MS, Berry R, Tiganis T, McCluskey J, Pellicci DG, Purcell AW, Uldrich AP, Godfrey DI, Rossjohn J. Le Nours J, et al. Science. 2019 Dec 20;366(6472):1522-1527. doi: 10.1126/science.aav3900. Science. 2019. PMID: 31857486

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