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Comment
. 2020 Apr 28;117(17):9148-9150.
doi: 10.1073/pnas.2004241117. Epub 2020 Apr 16.

Proresolving lipid mediators enhance PMN-mediated bacterial clearance

Lucy V Norling  1 , Mauro Perretti  1
Affiliations
Comment

Proresolving lipid mediators enhance PMN-mediated bacterial clearance

Lucy V Norling et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Specialized proresolving lipid mediators (SPMs) 15-epi-LXA4 and 17-epi-RvD1 restore impaired bacterial clearance and accelerate resolution of lung inflammation. Bacterial DNA (CpG DNA) are sensed via the pathogen recognition receptor TLR9 on neutrophils, which causes release of neutrophil elastase (NE) and proteinase 3 (PR3) and the subsequent cleavage of complement receptor (C5aR). This in turn impairs phagocytosis of E. coli and delays neutrophil apoptosis, leading to prolonged lung inflammation and bacterial infection (Left-Hand Side). By signaling through a specific G-protein–coupled receptor (GPCR), termed ALX/FPR2, 15-epi-LXA4 and 17-epi-RvD1 counterregulate signals from CpG DNA, allowing phagocytosis of E. coli and permitting neutrophils to undergo apoptosis, thereby promoting bacterial clearance and the resolution of pulmonary inflammation (Right-Hand Side).
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References

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