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. 2020 Sep 1;114(9):690-692.
doi: 10.1093/trstmh/traa019.

Evaluation of GeneXpert MTB/RIF as a diagnostic tool in patients with sputum smear-negative TB in a high HIV burden region in Nigeria

Abdulwasiu Bolaji Tiamiyu  1 , Garba Iliyasu  2 , Farouq Muhammad Dayyab  1 , Zaiyad Garba Habib  1 , Sirajo Haliru Tambuwal  1 , Habibu Galadanci  3 , Sunday A Bwala  3 , Lovett Lawson  4 , Abdulrazaq Garba Habib  2
Affiliations

Evaluation of GeneXpert MTB/RIF as a diagnostic tool in patients with sputum smear-negative TB in a high HIV burden region in Nigeria

Abdulwasiu Bolaji Tiamiyu et al. Trans R Soc Trop Med Hyg. .

Abstract

Background: There are challenges in the diagnosis of TB in people with smear-negative pulmonary TB (SNPTB) in resource-limited settings. We evaluated the diagnostic usefulness of Xpert MTB/RIF compared with TB culture among SNPTB.

Methods: The study was a cross-sectional study among patients with SNPTB. The Xpert MTB/RIF tests and sputum culture (using Lowenstein-Jensen medium) were performed. Sensitivity and specificity were calculated.

Results: Of 150 patients studied, the sensitivity and specificity of GeneXpert MTB/RIF were 81.8 and 97.4%, respectively.

Conclusion: The sensitivity and specificity of Xpert MTB/RIF assay was comparative with culture in SNPTB patients.

Keywords: Gene Xpert; HIV Infection; Nigeria; Smear Negative Pulmonary Tuberculosis; Sputum culture.

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