Treosulfan conditioning for allogeneic transplantation in multiple myeloma - improved overall survival in first line haematopoietic stem cell transplantation - a large retrospective study by the Chronic Malignancies Working Party of the EBMT

Affiliations

¹ Karolinska University Hospital, Stockholm, Sweden.
² EBMT Statistical Unit, Leiden, The Netherlands.
³ EBMT Data Office Leiden, Leiden, The Netherlands.
⁴ Universitätsklinikum Würzburg, Würzburg, Germany.
⁵ HUCH Comprehensive Cancer Center, Helsinki, Finland.
⁶ University Regensburg, Regensburg, Germany.
⁷ University Hospital, Essen, Germany.
⁸ Ospedale San Raffaele s.r.l., Milano, Italy.
⁹ Universitätsklinikum Dresden, Dresden, Germany.
¹⁰ University of Freiburg, Freiburg, Germany.
¹¹ Leiden University Medical Center, Leiden, The Netherlands.
¹² Klinikum Grosshadern, Munich, Germany.
¹³ Centre de Recherche Saint-Antoine- Team Proliferation and Differentiation of Stem Cells, Sorbonne Université, INSERM, UMR_S 938, Paris, France.
¹⁴ University Hospital of Heidelberg, Heidelberg, Germany.
¹⁵ University of Lille, CHU Lille, INSERM, Infinite, Lille, France.
¹⁶ University Hospital Eppendorf, Hamburg, Germany.

Comparative Study

Charlotte Gran et al. Br J Haematol. 2020 Jun.

. 2020 Jun;189(5):e213-e217.

doi: 10.1111/bjh.16642. Epub 2020 Apr 16.

¹ Karolinska University Hospital, Stockholm, Sweden.
² EBMT Statistical Unit, Leiden, The Netherlands.
³ EBMT Data Office Leiden, Leiden, The Netherlands.
⁴ Universitätsklinikum Würzburg, Würzburg, Germany.
⁵ HUCH Comprehensive Cancer Center, Helsinki, Finland.
⁶ University Regensburg, Regensburg, Germany.
⁷ University Hospital, Essen, Germany.
⁸ Ospedale San Raffaele s.r.l., Milano, Italy.
⁹ Universitätsklinikum Dresden, Dresden, Germany.
¹⁰ University of Freiburg, Freiburg, Germany.
¹¹ Leiden University Medical Center, Leiden, The Netherlands.
¹² Klinikum Grosshadern, Munich, Germany.
¹³ Centre de Recherche Saint-Antoine- Team Proliferation and Differentiation of Stem Cells, Sorbonne Université, INSERM, UMR_S 938, Paris, France.
¹⁴ University Hospital of Heidelberg, Heidelberg, Germany.
¹⁵ University of Lille, CHU Lille, INSERM, Infinite, Lille, France.
¹⁶ University Hospital Eppendorf, Hamburg, Germany.

No abstract available

Keywords: allogeneic stem cell transplantation; multiple myeloma; myeloablative conditioning; reduced intensity conditioning; treosulfan.

References

1. Nahi, H, Afram, G, Liwing, J, Heeg, B & Mattsson, J Treosulfan plus fludarabine - encouraging conditioning for alligenic hematopoietic stem cell transplantation in multiple myeloma. Journal of Cancer Science and Clinical Oncology. 2016;3:201.
1. Ploemacher RE, Johnson KW, Rombouts EJ, Etienne K, Westerhof GR, Baumgart J et al Addition of treosulfan to a nonmyeloablative conditioning regimen results in enhanced chimerism and immunologic tolerance in an experimental allogeneic bone marrow transplant model. Biol Blood Marrow Transplant. 2004;10:236-45.
1. Schmidt-Hieber M, Blau IW, Trenschel R, Andreesen R, Stuhler G, Einsele H et al Reduced-toxicity conditioning with fludarabine and treosulfan prior to allogeneic stem cell transplantation in multiple myeloma. Bone Marrow Transplant. 2007;39:389-96.
1. Sjoo F, Hassan Z, Abedi-Valugerdi M, Griskevicius L, Nilsson C, Remberger M et al Myeloablative and immunosuppressive properties of treosulfan in mice. Exp Hematol. 2006;34:115-21.
1. Westerhof GR, Ploemacher RE, Boudewijn A, Blokland I, Dillingh JH, McGown AT et al Comparison of different busulfan analogues for depletion of hematopoietic stem cells and promotion of donor-type chimerism in murine bone marrow transplant recipients. Cancer Res. 2000;60:5470-8.