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. 2020 Nov;23(4):517-522.
doi: 10.1111/ocr.12379. Epub 2020 May 4.

Smell and taste in titanium and nickel allergic sensitization in orthodontic patients

Martina Zigante  1 , Sandra Peternel  2 , Miranda Muhvic Urek  3 , Marijana Rincic Mlinaric  4 , Darko Pop Acev  5 , Stjepan Spalj  1
Affiliations

Smell and taste in titanium and nickel allergic sensitization in orthodontic patients

Martina Zigante et al. Orthod Craniofac Res. 2020 Nov.

Abstract

Objective: To assess the prevalence of allergic sensitization to titanium and nickel in orthodontic patients and to evaluate alterations of smell and taste.

Subjects and methods: A total of 250 subjects were invited to participate, 245 accepted. The age range was 11-45 years, 68% were females and 52% adolescents. An epicutaneous patch test was performed. Of the positive subjects in the patch test, 26 participated in the taste and smell testing and were matched by age and sex with 26 negative subjects.

Results: The prevalence of hypersensitivity to titanium and/or nickel in orthodontic patients was 15.5%. Taste and smell were more impaired in sensitized subjects (P ≤ .025), taste was more affected than smell and the tastes most affected were sour and bitter tastes, while the sweet taste was least impaired.

Conclusion: The allergic sensitization to titanium is more uncommon than to nickel, with altered smell and taste related to those hypersensitivities.

Keywords: nickel; orthodontics; smell; taste; titanium.

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References

REFERENCES

    1. Syed M, Chopra R, Sachdev V. Allergic reactions to dental materials - a systematic review. J Clin Diagn Res. 2015;9:4-9.
    1. Hostynek JJ, Maibach HI (eds). Nickel and the Skin: Absorption, Immunology, Epidemiology, and Metallurgy. Bosa Raton, FL: CRC Press; 2002.
    1. Koike M, Fujii H. In vitro assessment of corrosive properties of titanium as a biomaterial. J Oral Rehabil. 2001;28:540-548.
    1. Fragou S, Eliades T. Effect of topical fluoride application on titanium alloys: a review of effects and clinical implications. Pediatr Dent. 2010;32:99-105.
    1. Gölz L, Papageorgiou SN, Jäger A. Nickel hypersensitivity and orthodontic treatment: a systematic review and meta-analysis. Contact Dermatitis. 2015;73:1-14.

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