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Editorial
. 2020 May;23(7):1153-1164.
doi: 10.1017/S1368980019005251.

25-Hydroxyvitamin D assay standardisation and vitamin D guidelines paralysis

C T Sempos  1 , N Binkley  2
Affiliations
Editorial

25-Hydroxyvitamin D assay standardisation and vitamin D guidelines paralysis

C T Sempos et al. Public Health Nutr. 2020 May.
No abstract available

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Figures

Fig. 1
Fig. 1
Recommendations for interpreting serum levels of 25-hydroxyvitamin D. ‘A schematic representation of how different agencies and countries interpret serum levels of 25-hydroxyvitamin D is shown. Colour code: red denotes a state of severe deficiency (danger) that has to be corrected without exception; orange denotes a state of mild deficiency (modest concern), in which intervention is desirable; green denotes a state of sufficient supply that does not benefit from additional supplementation. AAP, American Academy of Pediatrics; AGS, American Geriatrics Society; DACH, Deutschland (Germany, Austria and Confoederatio Helvetica (Switzerland); IOF, International Osteoporosis Foundation; IOM, Institute of Medicine; SACN, Scientific Advisory Committee on Nutrition.’ Source: Bouillon(1)
Fig. 2
Fig. 2
Distribution of serum 25-hydroxyvitamin D values in normal and rachitic children, aged 2 months–6 years (Source: Arnaud et al.(18)) *‘Patient No. 7 represents 25-OH-D; this patient had received 400 IU of vitamin D2 daily’.
Fig. 3
Fig. 3
Vitamin D meta-analyses published since 1992. Source: PubMed: https://www.ncbi.nlm.nih.gov/pubmed/ (accessed September 2019)
Fig. 4
Fig. 4
Trends in original assay and standardised mean 25-hydroxyvitamin D concentrations in nmol/l, USA, 1988–2006 (National Health and Nutrition Examination Surveys: 1988–1994, 2001–2002, 2003–2004 and 2005–2006. Survey-specific weighting factors were used to calculate representative means for the entire USA in each survey period. Standardised means were based on model 1 results. Please see source for more details. Source: Schleicher et al.(14) (formula image, 1988–1994; formula image, 2001–2002; formula image, 2003–2004; formula image, 2005–2006)
Fig. 5
Fig. 5
Prevalence of vitamin D deficiency in Australian summer months (serum 25(OH)D concentration <20 ng/ml (50 nmol/l); survey weighting factors were used to calculate representative prevalence figures for each state or territory). Australian Health Survey non-indigenous participants by state and territory, Australia, 2011–2012. Source: Australian Bureau of Statistics(75) (formula image, 10 %; formula image, 10 to <20 %; formula image, 20 to <30 %; formula image, 30 to <40 %; formula image, 40 to <50 %)
Fig. 6
Fig. 6
Prevalence of vitamin D deficiency in Australian winter months (serum 25(OH)D concentration <20 ng/ml (50 nmol/l); survey weighting factors were used to calculate representative prevalence figures for each state or territory). Australian Health Survey non-indigenous participants by state and territory. Australia, 2011–2012. Source: Australian Bureau of Statistics(75) (formula image, 10 %; formula image, 10 to <20 %; formula image, 20 to <30 %; formula image, 30 to <40 %; formula image, 40 to <50 %)
Fig. 7
Fig. 7
Vitamin D papers published since 1922. Source: PubMed: https://www.ncbi.nlm.nih.gov/pubmed/ (accessed September 2019)
See this image and copyright information in PMC

References

    1. Bouillon R (2017) Comparative analysis of nutritional guidelines for vitamin D. Nat Rev Endocrinol 13, 466–479. - PubMed
    1. Pilz S, Zitterman A, Trummer C et al. (2019) Vitamin D testing and treatment: a narrative review of current evidence. Endocr Connect 8, R27–R43. - PMC - PubMed
    1. Lucas RM, Gorman S, Black L et al. (2017) Clinical, research, and public health implications of poor measurement of vitamin D status. J AOAC Int 100, 1225–1229. - PubMed
    1. Calvo MS & Lamberg-Allardt CJ (2017) Vitamin D research and public health nutrition: a current perspective. Public Health Nutr 20, 1713–1717. - PMC - PubMed
    1. Calvo MS (2019) Monitoring vitamin D status and intake in the US population: essential to understand the role of vitamin D in health. Am J Clin Nutr 110, 6–7. - PubMed

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