Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Jun;18(6):1521-1522.
doi: 10.1111/jth.14858. Epub 2020 May 6.

Potential of heparin and nafamostat combination therapy for COVID-19

Hidesaku Asakura  1 , Haruhiko Ogawa  2
Affiliations
Comment

Potential of heparin and nafamostat combination therapy for COVID-19

Hidesaku Asakura et al. J Thromb Haemost. 2020 Jun.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Anti‐COVID‐19 action by nafamostat (author's hypothesis). Nafamostat is anticipated to show anti‐viral and anti‐enhanced‐fibrinolysis disseminated intravascular coagulation effects. Nafamostat has weak anticoagulant effects, and combination with heparin may therefore be effective
See this image and copyright information in PMC

Comment on

References

    1. Tang N., Bai H., Chen X., Gong J., Li D., Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 2020 - PMC - PubMed
    1. Tang N., Li D., Wang X., Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020 - PMC - PubMed
    1. Asakura H. Classifying types of disseminated intravascular coagulation: clinical and animal models. J Intensive Care. 2014;2(1):20. - PMC - PubMed
    1. Zhou F., Yu T., Du R., et al. Clinical course and risk factors for mortality of adult inpatients with COVID‐19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054–1062. - PMC - PubMed
    1. Wu C., Chen X., Cai Y., et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease, pneumonia in wuhan, China. JAMA Intern Med. 2020 - PMC - PubMed