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Comment
. 2020 Apr 16;181(2):230-232.
doi: 10.1016/j.cell.2020.03.057.

SLeuthing Tuberculous Cough

Marcel A Behr  1 , Paul H Edelstein  2 , Lalita Ramakrishnan  3
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SLeuthing Tuberculous Cough

Marcel A Behr et al. Cell. .
Free article

Abstract

Cough, a hallmark of tuberculosis, transmits the disease. Ruhl et al. find that a Mycobacterium tuberculosis (Mtb)-specific lipid, SL-1, stimulates human nociceptive neurons and makes guinea pigs cough. Mtb extract, but not SL-1, also stimulates non-nociceptive neurons that participate in the cough reflex, suggesting additional cough-inducing mechanisms.

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