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Review
. 2020 Jun 18:388:112620.
doi: 10.1016/j.bbr.2020.112620. Epub 2020 Apr 14.

IntelliCage as a tool for measuring mouse behavior - 20 years perspective

Anna Kiryk  1 , Artur Janusz  1 , Bartosz Zglinicki  1 , Emir Turkes  2 , Ewelina Knapska  3 , Witold Konopka  1 , Hans-Peter Lipp  4 , Leszek Kaczmarek  5
Affiliations
Free article
Review

IntelliCage as a tool for measuring mouse behavior - 20 years perspective

Anna Kiryk et al. Behav Brain Res. .
Free article

Abstract

Since the 1980s, we have witnessed the rapid development of genetically modified mouse models of human diseases. A large number of transgenic and knockout mice have been utilized in basic and applied research, including models of neurodegenerative and neuropsychiatric disorders. To assess the biological function of mutated genes, modern techniques are critical to detect changes in behavioral phenotypes. We review the IntelliCage, a high-throughput system that is used for behavioral screening and detailed analyses of complex behaviors in mice. The IntelliCage was introduced almost two decades ago and has been used in over 150 studies to assess both spontaneous and cognitive behaviors. We present a critical analysis of experimental data that have been generated using this device.

Keywords: Behavior; Cognitive functions; Depression; Emotional tests; Ethological approach; Human disorders; IntelliCage; Learning and memory; Mice; Transgenic models.

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Conflict of interest statement

Declaration of Competing Interest Prof. Hans-Peter Lipp developed the idea of the IntelliCage based on his original experiments. Prof. Lipp owns shares in NewBehavior Company. The system was initially marketed by NewBehavior GmbH (Zürich, Switzerland), which is now fully owned by TSE-Systems International (Frankfurt, Germany). Prof. Lipp owns a consulting company (Neurospex GmbH) that provides advice for IntelliCage users and also designs other neurobehavioral projects and is co-owner of XBehavior GmbH, a company that provides automated R-based analyses of IntelliCage and GPS tracking data and extended programming capacities for IntelliCage users.

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