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Review
. 2020 Jun;30(6):440-451.
doi: 10.1016/j.tcb.2020.03.002. Epub 2020 Apr 14.

The Complex Interplay between Antioxidants and ROS in Cancer

Isaac S Harris  1 , Gina M DeNicola  2
Affiliations
Review

The Complex Interplay between Antioxidants and ROS in Cancer

Isaac S Harris et al. Trends Cell Biol. 2020 Jun.

Abstract

Reactive oxygen species (ROS) play important roles in tissue homeostasis, cellular signaling, differentiation, and survival. In this review, we discuss the types ofROS, their impact on cellular processes, and their pro- and antitumorigenic effects. Further, we discuss recent advances in our understanding of both endogenous and exogenous antioxidants in tumorigenic processes. Finally, wediscuss how aberrant activation of antioxidant programs by the transcription factor NFE2-related factor 2 (NRF2) influences tumorigenesis and metastasis, and where the current gaps in our knowledge remain.

Keywords: NRF2; ROS; antioxidant; cancer; glutathione.

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