Response to recent commentaries regarding the involvement of angiotensin-converting enzyme 2 (ACE2) and renin-angiotensin system blockers in SARS-CoV-2 infections

Robert C Speth^{1

2}

Affiliations

¹ Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, Florida, USA.
² Department of Pharmacology and Physiology, College of Medicine, Georgetown University, Washington, District of Columbia, USA.

Comment

Robert C Speth. Drug Dev Res. 2020 Sep.

. 2020 Sep;81(6):643-646.

doi: 10.1002/ddr.21672. Epub 2020 Apr 17.

Robert C Speth^{1

2}

¹ Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, Florida, USA.
² Department of Pharmacology and Physiology, College of Medicine, Georgetown University, Washington, District of Columbia, USA.

No abstract available

Comment on

Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics.
Gurwitz D. Gurwitz D. Drug Dev Res. 2020 Aug;81(5):537-540. doi: 10.1002/ddr.21656. Epub 2020 Mar 4. Drug Dev Res. 2020. PMID: 32129518 Free PMC article.
Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?
Fang L, Karakiulakis G, Roth M. Fang L, et al. Lancet Respir Med. 2020 Apr;8(4):e21. doi: 10.1016/S2213-2600(20)30116-8. Epub 2020 Mar 11. Lancet Respir Med. 2020. PMID: 32171062 Free PMC article. No abstract available.

1. Chappell, M. C. , Pirro, N. T. , Sykes, A. , & Ferrario, C. M. (1998). Metabolism of angiotensin‐(1‐7) by angiotensin‐converting enzyme. Hypertension, 31(1 Pt 2), 362–367. - PubMed
1. Dales, N. A. , Gould, A. E. , Brown, J. A. , Calderwood, E. F. , Guan, B. , Minor, C. A. , … Patane, M. A. (2002). Substrate‐based design of the first class of angiotensin‐converting enzyme‐related carboxypeptidase (ACE2) inhibitors. Journal of the American Chemical Society, 124(40), 11852–11853. - PubMed
1. Danser, A. H. J. , Epstein, M. , & Batlle, D. (2020). Renin‐angiotensin system blockers and the COVID‐19 pandemic. Hypertension. 10.1161/HYPERTENSIONAHA.120.15082 - DOI - PMC - PubMed
1. Fang, L. , Karakiulakis, G. , & Roth, M. (2020). Are patients with hypertension and diabetes mellitus at increased risk for COVID‐19 infection? The Lancet Respiratory Medicine. 10.1016/PII - DOI - PMC - PubMed
1. Forrester, S. J. , Booz, G. W. , Sigmund, C. D. , Coffman, T. M. , Kawai, T. , Rizzo, V. , … Eguchi, S. (2018). Angiotensin II signal transduction: An update on mechanisms of physiology and pathophysiology. Physiological Reviews, 98(3), 1627–1738. 10.1152/physrev.00038.2017 - DOI - PMC - PubMed