Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jul;40(7):1634-1644.
doi: 10.1111/liv.14480. Epub 2020 May 2.

Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study

Lisbet Grønbaek  1   2   3   4 , Harmony Otete  3   5 , Lu Ban  6   7 , Colin Crooks  6   7 , Timothy Card  3   6 , Peter Jepsen  1   2   3 , Joe West  3   6
Affiliations

Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study

Lisbet Grønbaek et al. Liver Int. 2020 Jul.

Abstract

Background & aims: There are few population-based studies of the incidence and mortality of autoimmune hepatitis. The burden of the disease and how it has changed over time have not been fully explored. We conducted a population-based cohort study on the incidence and mortality of autoimmune hepatitis in England, 1997-2015.

Methods: From the Clinical Practice Research Datalink we included 882 patients diagnosed with autoimmune hepatitis in England, 1997-2015. The patients were followed through 2015, and we calculated the sex- and age-standardized incidence and prevalence of autoimmune hepatitis. We examined variation in incidence by sex, age, calendar year, geographical region and socioeconomic status, and incidence rate ratios were calculated with Poisson regression. We calculated all-cause and cause-specific mortality.

Results: The overall standardized incidence rate of autoimmune hepatitis was 2.08 (95% confidence interval 1.94-2.22) per 100,000 population per year, higher in women, higher in older age and independent of region and socioeconomic status. From 1997 to 2015 the incidence doubled from 1.27 (95% confidence interval 0.51-2.02) to 2.56 (95% confidence interval 1.79-3.33) per 100,000 population per year. The 10-year cumulative all-cause mortality was 31.9% (95% confidence interval 27.6-36.5), and the 10-year cumulative liver-related mortality, including hepatocellular carcinoma was ~10.5%.

Conclusions: This population-based study showed that the incidence of autoimmune hepatitis doubled over an eighteen-year period. The incidence was particularly high in older women and was similar across all regions of England and independent of socioeconomic status. Patients with autoimmune hepatitis had a high mortality.

Keywords: autoimmune; cohort study; epidemiology; hepatitis; incidence; prevalence; prognosis; registry.

PubMed Disclaimer

References

REFERENCES

    1. Manns MP, Lohse AW, Vergani D. Autoimmune hepatitis - update 2015. J Hepatol. 2015;62(1S):S100-S111.
    1. Grønbaek L, Vilstrup H, Pedersen L, Christensen K, Jepsen P. Family occurrence of autoimmune hepatitis: a Danish nationwide registry-based cohort study. J Hepatol. 2018;69(4):873-877.
    1. Yoshizawa K, Joshita S, Matsumoto A, et al. Incidence and prevalence of autoimmune hepatitis in the Ueda area, Japan. Hepatol Res. 2015;46(9):848-852.
    1. Jepsen P, Grønbaek L, Vilstrup H. Worldwide incidence of autoimmune liver disease. Dig Dis. 2015;33(Suppl 2):2-12.
    1. Danielsson Borssén Å, Marschall H-U, Bergquist A, et al. Epidemiology and causes of death in a Swedish cohort of patients with autoimmune hepatitis. Scand J Gastroenterol. 2017;52(9):1022-1028.

Publication types

LinkOut - more resources