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Comparative Study
. 2020 Aug:216:147-155.
doi: 10.1016/j.ajo.2020.04.010. Epub 2020 Apr 15.

Globe Axial Length Growth at Age 10.5 Years in the Infant Aphakia Treatment Study

M Edward Wilson  1 , Rupal H Trivedi  2 , David R Weakley Jr  3 , George A Cotsonis  4 , Scott R Lambert  5 ; Infant Aphakia Treatment Study Group
Affiliations
Comparative Study

Globe Axial Length Growth at Age 10.5 Years in the Infant Aphakia Treatment Study

M Edward Wilson et al. Am J Ophthalmol. 2020 Aug.

Abstract

Purpose: To report the change in globe axial length (AL) from the time of unilateral cataract surgery at age 1-7 months to age 10.5 years for infants enrolled in the Infant Aphakia Treatment Study, and to compare AL growth of operated eyes with that of fellow unoperated eyes.

Design: Comparative case series.

Methods: AL growth was analyzed relative to treated vs fellow eye, contact lens (CL) vs intraocular lens (IOL), visual acuity (VA) outcome, and the need for surgery for visual axis opacification. Eyes with glaucoma or glaucoma suspect were excluded from the primary analysis but reported separately.

Results: Fifty-seven patients have reliable AL data available at both visits. AL was shorter in treated eyes preoperatively (P < .0001) and at 10.5 years of age (P = .021) but AL growth was not different (4.7 mm, P = .99). The growth (70.2% up to age 5 and 29.8% from age 5 to 10.5) was similar in the CL and the IOL group (P = .79). Eyes grew 4.4 mm when visual acuity (VA) was better than 20/200, and 5.2 mm when VA was 20/200 or worse (P = .076). Eyes receiving additional surgery grew more than eyes not receiving additional surgery (P = .052). Patients with glaucoma showed significantly more eye growth (7.3 mm) than those without glaucoma (4.7 mm) and glaucoma suspects (5.1 mm) (P < .05).

Conclusions: Eyes with glaucoma or poor VA often grew longer than the fellow eye. Overall, treated eyes grew similarly in the IOL and CL groups and also kept pace with the growth of the fellow eyes.

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Figures

FIGURE 1.
FIGURE 1.
Correlation of logMAR visual acuity and axial length at 10.5 years of age.
FIGURE 2.
FIGURE 2.
Correlation of logMAR visual acuity and axial length growth from preoperative visit to age 10.5 years.
FIGURE 3.
FIGURE 3.
Correlation of logMAR visual acuity and axial length growth from 5 to 10.5 years of age.
FIGURE 4.
FIGURE 4.
A. Correlation of baseline axial length and axial length growth from baseline to 10.5 years of age in the treated eye. B. Correlation of baseline axial length and axial length growth from baseline to 10.5 years of age in the fellow eye.
See this image and copyright information in PMC

References

    1. Lambert SR. Changes in ocular growth after pediatric cataract surgery. Dev Ophthalmol 2016;57:29–39. - PubMed
    1. Lambert SR, Lynn MJ, DuBois LG, et al.; Infant Aphakia Treatment Study Groups. Axial elongation following cataract surgery during the first year of life in the infant Aphakia Treatment Study. Invest Ophthalmol Vis Sci 2012;53(12): 7539–7545. - PMC - PubMed
    1. Wilson ME, Trivedi RH, Weakley DR Jr, Cotsonis GA, Lambert SR, Infant Aphakia Treatment Study Group. Globe axial length growth at age 5 years in the Infant Aphakia Treatment Study. Ophthalmology 2017;124(5): 730–733. - PMC - PubMed
    1. Infant Aphakia Treatment Study Group, Lambert SR, Buckley EG, Drews-Botsch C, et al. The infant Aphakia treatment study: design and clinical measures at enrollment. Arch Ophthalmol 2010;128(1):21–27. - PMC - PubMed
    1. Kugelberg U, Zetterstrom C, Syren-Nordqvist S. Ocular axial length in children with unilateral congenital cataract. Acta Ophthalmol Scand 1996;74(3):220–223. - PubMed

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