An Antiviral DNA Response without the STING?
- PMID: 32305305
- DOI: 10.1016/j.it.2020.03.010
An Antiviral DNA Response without the STING?
Abstract
Higher eukaryotes have evolved elegant and redundant pathways to protect their genomes from both genotoxic stressors and foreign DNA from invading pathogens. Emerging data from Burleigh et al. suggest that these distinct pathways may share factors to enhance the functional redundancy of both.
Copyright © 2020 Elsevier Ltd. All rights reserved.
Comment on
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Human DNA-PK activates a STING-independent DNA sensing pathway.Sci Immunol. 2020 Jan 24;5(43):eaba4219. doi: 10.1126/sciimmunol.aba4219. Sci Immunol. 2020. PMID: 31980485 Free PMC article.
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