Podocytes: The Role of Lysosomes in the Development of Nephrotic Syndrome

Affiliations

¹ Nephrology Unit, Department of Emergency and Transplant Organs, University Aldo Moro of Bari, Bari, Italy.
² Nephrology Unit, Department of Emergency and Transplant Organs, University Aldo Moro of Bari, Bari, Italy. Electronic address: loreto.gesualdo@uniba.it.

Free article

Comment

Marica Giliberti et al. Am J Pathol. 2020 Jun.

Free article

. 2020 Jun;190(6):1172-1174.

doi: 10.1016/j.ajpath.2020.04.001. Epub 2020 Apr 16.

¹ Nephrology Unit, Department of Emergency and Transplant Organs, University Aldo Moro of Bari, Bari, Italy.
² Nephrology Unit, Department of Emergency and Transplant Organs, University Aldo Moro of Bari, Bari, Italy. Electronic address: loreto.gesualdo@uniba.it.

Abstract

This commentary highlights the article by Li et al that links ceramide accumulation in podocytes to cellular damage and nephrotic syndrome.

Podocytopathy and Nephrotic Syndrome in Mice with Podocyte-Specific Deletion of the Asah1 Gene: Role of Ceramide Accumulation in Glomeruli.
Li G, Kidd J, Kaspar C, Dempsey S, Bhat OM, Camus S, Ritter JK, Gehr TWB, Gulbins E, Li PL. Li G, et al. Am J Pathol. 2020 Jun;190(6):1211-1223. doi: 10.1016/j.ajpath.2020.02.008. Epub 2020 Mar 16. Am J Pathol. 2020. PMID: 32194052 Free PMC article.