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. 2020 Jun;55(6):105982.
doi: 10.1016/j.ijantimicag.2020.105982. Epub 2020 Apr 16.

Cytokine storm and immunomodulatory therapy in COVID-19: Role of chloroquine and anti-IL-6 monoclonal antibodies

Ming Zhao  1
Affiliations

Cytokine storm and immunomodulatory therapy in COVID-19: Role of chloroquine and anti-IL-6 monoclonal antibodies

Ming Zhao. Int J Antimicrob Agents. 2020 Jun.

Abstract

  1. •

    Discussion of the role of immunomodulatory agents to reduce the cytokine storm in severe cases of COVID-19.

  2. •

    Potential immunomodulatory agents currently used in the treatment of COVID-19 (chloroquine, hydroxychloroquine and tocilizumab) are discussed.

  3. •

    Other immunomodulatory agents with good safety profiles may be considered for use in combination with antiviral drugs for the treatment of severe or critical cases of COVID-19.

Keywords: COVID-19; Chloroquine; Cytokine storm; Hydroxychloroquine; Tocilizumab.

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