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. 2019 Oct 24;34(2):86-93.
doi: 10.7555/JBR.33.20190075.

Contribution of neutrophils in the pathogenesis of rheumatoid arthritis

Lingshu Zhang  1 , Yi Yuan  2 , Qiang Xu  1 , Zhengyu Jiang  2 , Cong-Qiu Chu  1
Affiliations

Contribution of neutrophils in the pathogenesis of rheumatoid arthritis

Lingshu Zhang et al. J Biomed Res. .

Abstract

Neutrophils are major innate immune effector cells for host defense and have been a topic of active research for their participation in the pathogenesis of autoimmune inflammatory diseases including rheumatoid arthritis (RA) due to recently discovered neutrophil extracellular trap (NET) formation. NET formation and other mechanisms leading to the release of neutrophil nuclear and cytoplasmic contents are implicated as a source of citrullinated antigens in RA. Further investigations are required to delineate what factors diverge neutrophils from host defense to autoimmune response in RA.

Keywords: NET formation; neutrophils; rheumatoid arthritis.

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Figures

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1. Neutrophil centered etiology and pathogenesis of RA.
See this image and copyright information in PMC

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