Chronotherapy in hypertension: the devil is in the details

Affiliations

¹ Medicines Monitoring Unit & Hypertension Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD2 1GZ, UK.
² Faculty of Medicine, School of Public Health, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
³ Robertson Centre for Biostatistics, University of Glasgow, Boyd Orr Building, Glasgow G12 8QQ, UK.
⁴ Institute of Cardiovascular Sciences, University College London, Maple House, 149 Tottenham Court Road, London W1T 7DN, UK.
⁵ Centre of Clinical Pharmacology, Queen Mary University of London, Mile End Road, London E1 4NS, UK.
⁶ Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee DD1 4HN, UK.
⁷ Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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Greg Guthrie et al. Eur Heart J. 2020.

Free article

. 2020 Apr 21;41(16):1606-1607.

doi: 10.1093/eurheartj/ehaa265.

¹ Medicines Monitoring Unit & Hypertension Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD2 1GZ, UK.
² Faculty of Medicine, School of Public Health, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
³ Robertson Centre for Biostatistics, University of Glasgow, Boyd Orr Building, Glasgow G12 8QQ, UK.
⁴ Institute of Cardiovascular Sciences, University College London, Maple House, 149 Tottenham Court Road, London W1T 7DN, UK.
⁵ Centre of Clinical Pharmacology, Queen Mary University of London, Mile End Road, London E1 4NS, UK.
⁶ Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee DD1 4HN, UK.
⁷ Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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Comparing the design of the primary-care based Hygia Chronotherapy Trial and the Internet-Based TIME Study.
Hermida RC, Mojón A, Fernández JR; Hygia Project Investigators. Hermida RC, et al. Eur Heart J. 2020 Apr 21;41(16):1608. doi: 10.1093/eurheartj/ehaa276. Eur Heart J. 2020. PMID: 32306035 No abstract available.

Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial.
Hermida RC, Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ, Fernández JR, Mojón A, Ayala DE; Hygia Project Investigators. Hermida RC, et al. Eur Heart J. 2020 Dec 21;41(48):4565-4576. doi: 10.1093/eurheartj/ehz754. Eur Heart J. 2020. PMID: 31641769 Clinical Trial.