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Comparative Study
. 2020 Jun;52(6):1135-1142.
doi: 10.1007/s11255-020-02461-7. Epub 2020 Apr 18.

Interleukin 6 is a better predictor of 5-year cardiovascular mortality than high-sensitivity C-reactive protein in hemodialysis patients using reused low-flux dialyzers

Le Viet Thang  1 , Nguyen Duc Loc  2 , Nguyen Trung Kien  3 , Nguyen Huu Dung  4 , Dao Bui Quy Quyen  5 , Nguyen Minh Tuan  5 , Do Manh Ha  3 , Truong Quy Kien  3 , Nguyen Thi Thuy Dung  3 , Diem Thi Van  3 , Nguyen Van Duc  3 , Nguyen Thi Thu Ha  3 , Pham Quoc Toan  3 , Vu Xuan Nghia  6
Affiliations
Comparative Study

Interleukin 6 is a better predictor of 5-year cardiovascular mortality than high-sensitivity C-reactive protein in hemodialysis patients using reused low-flux dialyzers

Le Viet Thang et al. Int Urol Nephrol. 2020 Jun.

Erratum in

Abstract

Purpose: In this study, we focused on the role of elevated serum interleukin 6 (IL-6) concentration in predicting 5-year cardiovascular mortality in hemodialysis patients using low-flux dialyzer reuse.

Materials and methods: We measured serum IL-6 concentrations in 236 hemodialysis patients (138 males and 98 females) to predict 5-year cardiovascular mortality. We assessed the baseline demographics of all patients who had a mean age of 44 years and a median hemodialysis duration of 38.5 months. We divided all patients into two equal groups based on the serum IL-6 concentration: G1 (n = 118) with serum IL-6 concentration < 6.78 pg/L and G2 (n = 118) with serum IL-6 concentration ≥ 6.78 pg/L.

Results: After the 5-year follow-up, 45 patients died due to cardiovascular causes (19.1%). Lipid disorder, hemoglobin, serum albumin, β2-M, and IL-6 concentration were independent risk factors for predicting cardiovascular mortality during the 60-month follow-up in hemodialysis patients. Based on the Kaplan-Meier analysis, we realized that patients with a higher interleukin 6 concentration (G2) had a significantly higher cardiovascular mortality rate than patients in G1 (log-rank test p < 0.001). Serum IL-6 concentration was a better predictor of 5-year cardiovascular mortality than high-sensitivity C-reactive protein in hemodialysis patients using low-flux dialyzer reuse (AUC = 0.818; p < 0.001; cut-off value: 8.055 pg/mL, Se = 77.8%, Sp = 78.5%).

Conclusion: Serum IL-6 concentration was a better predictor of 5-year cardiovascular mortality than high-sensitivity C-reactive protein in maintenance hemodialysis patients using low-flux dialysis reuse.

Keywords: Cardiovascular cause mortality; Hemodialysis; Interleukin 6; Reused low-flux dialyzers.

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