cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading

David N Louis¹, Pieter Wesseling^{2

3}, Kenneth Aldape⁴, Daniel J Brat⁵, David Capper^{6

7}, Ian A Cree⁸, Charles Eberhart⁹, Dominique Figarella-Branger¹⁰, Maryam Fouladi¹¹, Gregory N Fuller¹², Caterina Giannini^{13

14}, Christine Haberler¹⁵, Cynthia Hawkins¹⁶, Takashi Komori¹⁷, Johan M Kros¹⁸, H K Ng¹⁹, Brent A Orr²⁰, Sung-Hye Park²¹, Werner Paulus²², Arie Perry²³, Torsten Pietsch²⁴, Guido Reifenberger^{25

26}, Marc Rosenblum²⁷, Brian Rous^{8

28}, Felix Sahm^{29

30

31}, Chitra Sarkar³², David A Solomon²³, Uri Tabori³³, Martin J van den Bent³⁴, Andreas von Deimling^{29

30}, Michael Weller³⁵, Valerie A White⁸, David W Ellison^{8

20}

Affiliations

¹ Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
² Department of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, The Netherlands.
³ Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
⁴ Laboratory of Pathology, National Cancer Institute, Bethesda, MD.
⁵ Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL.
⁶ Department of Neuropathology, Humboldt-Universität zu Berlin and Berlin Institute of Health, Corporate Member of Freie Universität Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁷ German Cancer Research Center, German Cancer Consortium, Partner Site Berlin, Heidelberg, Germany.
⁸ International Agency for Research on Cancer, World Health Organization, Lyon, France.
⁹ Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD.
¹⁰ Service d'Anatomie Pathologique et de Neuropathologie, Hôpital de la Timone, Institut de Neurophysiopathology, Aix-Marseille Univ, APHM, CNRS, Marseille, France.
¹¹ Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH.
¹² Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX.
¹³ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
¹⁴ Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
¹⁵ Institute of Neurology, Medical University of Vienna, Vienna, Austria.
¹⁶ Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
¹⁷ Department of Laboratory Medicine and Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
¹⁸ Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands.
¹⁹ Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong, China.
²⁰ Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.
²¹ Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea.
²² Institute of Neuropathology, University Hospital Munster, Munster, Germany.
²³ Department of Pathology, University of California San Francisco, San Francisco, CA.
²⁴ Department of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn, Bonn, Germany.
²⁵ Department of Neuropathology, Heinrich Heine University, Duesseldorf, Germany.
²⁶ German Cancer Consortium, Partner Site Essen/Duesseldorf, Essen, Germany.
²⁷ Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY.
²⁸ Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
²⁹ Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany.
³⁰ Clinical Cooperation Unit Neuropathology, German Cancer Research Center, German Cancer Consortium, Heidelberg, Germany.
³¹ Hopp Children's Cancer Center, NCT Heidelberg, Heidelberg, Germany.
³² Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
³³ Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
³⁴ Department of Neurology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
³⁵ Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.

PMID: 32307792
PMCID: PMC8018152
DOI: 10.1111/bpa.12832

Practice Guideline

cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading

David N Louis et al. Brain Pathol. 2020 Jul.

. 2020 Jul;30(4):844-856.

doi: 10.1111/bpa.12832. Epub 2020 Apr 19.

Authors

Affiliations

¹ Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
² Department of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, The Netherlands.
³ Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
⁴ Laboratory of Pathology, National Cancer Institute, Bethesda, MD.
⁵ Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL.
⁶ Department of Neuropathology, Humboldt-Universität zu Berlin and Berlin Institute of Health, Corporate Member of Freie Universität Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁷ German Cancer Research Center, German Cancer Consortium, Partner Site Berlin, Heidelberg, Germany.
⁸ International Agency for Research on Cancer, World Health Organization, Lyon, France.
⁹ Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD.
¹⁰ Service d'Anatomie Pathologique et de Neuropathologie, Hôpital de la Timone, Institut de Neurophysiopathology, Aix-Marseille Univ, APHM, CNRS, Marseille, France.
¹¹ Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH.
¹² Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX.
¹³ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
¹⁴ Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
¹⁵ Institute of Neurology, Medical University of Vienna, Vienna, Austria.
¹⁶ Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
¹⁷ Department of Laboratory Medicine and Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
¹⁸ Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands.
¹⁹ Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong, China.
²⁰ Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.
²¹ Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea.
²² Institute of Neuropathology, University Hospital Munster, Munster, Germany.
²³ Department of Pathology, University of California San Francisco, San Francisco, CA.
²⁴ Department of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn, Bonn, Germany.
²⁵ Department of Neuropathology, Heinrich Heine University, Duesseldorf, Germany.
²⁶ German Cancer Consortium, Partner Site Essen/Duesseldorf, Essen, Germany.
²⁷ Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY.
²⁸ Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
²⁹ Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany.
³⁰ Clinical Cooperation Unit Neuropathology, German Cancer Research Center, German Cancer Consortium, Heidelberg, Germany.
³¹ Hopp Children's Cancer Center, NCT Heidelberg, Heidelberg, Germany.
³² Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
³³ Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
³⁴ Department of Neurology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
³⁵ Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.

PMID: 32307792
PMCID: PMC8018152
DOI: 10.1111/bpa.12832

Abstract

cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to evaluate and make practical recommendations on recent advances in the field of CNS tumor classification, particularly in light of the rapid progress in molecular insights into these neoplasms. For Round 2 of its deliberations, cIMPACT-NOW Working Committee 3 was reconstituted and convened in Utrecht, The Netherlands, for a meeting designed to review putative new CNS tumor types in advance of any future World Health Organization meeting on CNS tumor classification. In preparatory activities for the meeting and at the actual meeting, a list of possible entities was assembled and each type and subtype debated. Working Committee 3 recommended that a substantial number of newly recognized types and subtypes should be considered for inclusion in future CNS tumor classifications. In addition, the group endorsed a number of principles-relating to classification categories, approaches to classification, nomenclature, and grading-that the group hopes will also inform the future classification of CNS neoplasms.

Keywords: brain tumors; central nervous system; classification; neoplasms.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest relating to the information presented in the manuscript.

Comment in

The IMPACT of Molecular Grading of Gliomas on Contemporary Clinical Practice.
Milano MT, Chan MD, Minniti G, Hattangadi-Gluth JA, Redmond KJ, Soltys SG. Milano MT, et al. Int J Radiat Oncol Biol Phys. 2020 Aug 1;107(5):859-862. doi: 10.1016/j.ijrobp.2020.05.043. Int J Radiat Oncol Biol Phys. 2020. PMID: 32698972 No abstract available.

References

1. Andreiuolo F, Le Teuff G, Bayar MA, Kilday JP, Pietsch T, von Bueren AO et al (2017) Integrating tenascin‐C protein expression and 1q25 copy number status in pediatric intracranial ependymoma prognostication: a new model for risk stratification. PLoS ONE 12:e0178351. - PMC - PubMed
1. Andreiuolo F, Varlet P, Tauziede‐Espariat A, Junger ST, Dorner E, Dreschmann V et al (2019) Childhood supratentorial ependymomas with YAP1‐MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features. Brain Pathol 29:205–216. - PMC - PubMed
1. Appay R, Macagno N, Padovani L, Korshunov A, Kool M, Andre N et al (2017) HGNET‐BCOR tumors of the cerebellum: clinicopathologic and molecular characterization of 3 cases. Am J Surg Pathol 41:1254–1560. - PubMed
1. Araki A, Chocholous M, Gojo J, Dorfer C, Czech T, Heinzl H et al (2016) Chromosome 1q gain and tenascin‐C expression are candidate markers to define different risk groups in pediatric posterior fossa ependymoma. Acta Neuropathol Commun 4:88. - PMC - PubMed
1. Baisden BL, Brat DJ, Melhem ER, Rosenblum MK, King AP, Burger PC (2001) Dysembryoplastic neuroepithelial tumor‐like neoplasm of the septum pellucidum: a lesion often misdiagnosed as glioma: report of 10 cases. Am J Surg Pathol 25:494–499. - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

Grants and funding

001/WHO_/World Health Organization/International

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
Medical
- ClinicalTrials.gov

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading

Affiliations

cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading

Authors

Affiliations

Abstract

Conflict of interest statement

Comment in

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical