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Review
. 2020 Jul;12(7):861-886.
doi: 10.1002/dta.2806. Epub 2020 May 29.

Adulterants in selected dietary supplements and their detection methods

Liliana Muschietti  1 , Flavia Redko  1 , Jerónimo Ulloa  1
Affiliations
Review

Adulterants in selected dietary supplements and their detection methods

Liliana Muschietti et al. Drug Test Anal. 2020 Jul.

Abstract

At present, there is a growing trend toward the intentional adulteration of dietary supplements (DS) with synthetic pharmaceuticals, which represents an alarming emerging risk to consumers and a serious problem for regulatory agencies. An amazing array of synthetic drugs and their analogues have been reported as adulterants in DS. Mainly, the presence of analogues represents a serious health risk as their efficacy and toxic effects have not been clinically assessed yet and may result in unpredictable adverse effects. The purpose of this review is to provide an overview, over the period 2009-2019, of the most frequently reported adulterants in DS for the treatment of erectile dysfunction, obesity/overweight, diabetes mellitus, and hypertension and the analytical methods used for their detection.

Keywords: adulteration; analytical methods; dietary supplements.

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References

REFERENCES

    1. Bailey RL. Current regulatory guidelines and resources to support research of dietary supplements in the United States. Crit Rev Food Sci Nutr. 2018;60(2):1-12. https://doi.org/10.1080/10408398.2018.1524364
    1. Bailey RL, Gahche JJ, Miller PE, Thomas PR, Dwyer JT. Why US adults use dietary supplements. JAMA Int Med. 2013;173(5):355-361. https://doi.org/10.1001/jamainternmed.2013.2299
    1. Pawar RS, Grundel E. Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs). Drug Test Anal. 2017;9(3):500-517. https://doi.org/10.1002/dta.1980
    1. Tucker J, Fischer T, Upjohn L, Mazzera D, Kumar M. Unapproved pharmaceutical ingredients included in dietary supplements associated with US Food and Drug Administration warnings. JAMA Netw Open. 2018;1(6):e183337. https://doi.org/10.1001/jamanetworkopen.2018.3337
    1. National Institutes of Health. Dietary Supplement Health and Education Act of 1994. 1994. https://ods.od.nih.gov/About/DSHEA_Wording.aspx. Accessed Nov 20, 2019.

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