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Review
. 2020 Mar 18;13(3):493-502.
doi: 10.18240/ijo.2020.03.19. eCollection 2020.

Corneal graft melting: a systematic review

Bin-Bin Zhu  1 , Jie Zhou  1 , Jiao Zheng  1 , Yue Zhang  1 , Ting Wan  1 , Xiao-Dan Huang  1 , Lin Lin  1 , Xiu-Ming Jin  1
Affiliations
Review

Corneal graft melting: a systematic review

Bin-Bin Zhu et al. Int J Ophthalmol. .

Abstract

Corneal graft melting is a severe complication of keratoplasty. This review is to summarize the incidence, the pathogenesis, the risk factors, the prognosis and the prevention of corneal graft melting after keratoplasty. We systematically searched PubMed, Web of Science and WanFang database to retrieve potentially eligible articles about relevant clinical reports and animal experiments. We read the full texts to identify eligible articles. The selection of studies and data extraction were performed independently by two reviewers. In conclusion, the pathogenesis of corneal graft melting is complicated, and many risk factors are closely related to corneal graft melting. Analysis of pathogenesis and risk factors of corneal graft melting can facilitate the development of targeted therapies to better guide clinical practice.

Keywords: complication; corneal graft melting; incidence; keratoplasty.

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Figures

Figure 1
Figure 1. Major pathogenesis of corneal graft melting
A variety of inflammatory cytokines, polymorphonuclear neutrophils, T cells participate in the progress of corneal graft melting.
See this image and copyright information in PMC

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