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Review
. 2015 Dec 31;3(4):e53.
doi: 10.15190/d.2015.45.

AMPK activation can delay aging

Andreea L Stancu  1
Affiliations
Review

AMPK activation can delay aging

Andreea L Stancu. Discoveries (Craiova). .

Abstract

AMPK controls the regulation of cellular homeostasis, metabolism, resistance to stress, cell survival and growth, cell death, autophagy, which are some of the most critical determinants of aging and lifespan. Specific AMPK activation was recently shown to delay aging and prolong lifespan in Drosophila melanogaster. Indirect AMPK activators, such as resveratrol, metformin and exercise, are currently in clinical trials for studying their impact on human aging-related characteristics, tissue homeostasis and metabolic dysfunctions. In this minireview, I am briefly discussing the recent advances on AMP involvement in aging and lifespan elongation.

Keywords: AMP-activated protein kinase; energetic metabolism; lifespan.

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Conflict of interest statement

Conflict of interests: The author declares that there are no conflicts of interest.

References

    1. Regulation of AMP-activated protein kinase by natural and synthetic activators. Grahame Hardie David. Acta pharmaceutica Sinica. B. 2016;6(1):1–19. - PMC - PubMed
    1. AMPK and SIRT1: a long-standing partnership? Ruderman Neil B., Julia Xu X., Nelson Lauren, Cacicedo José M., Saha Asish K., Lan Fan, Ido Yasuo. American Journal of Physiology-Endocrinology and Metabolism. 2010;298(4):E751-E760. - PMC - PubMed
    1. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Salminen Antero, Kaarniranta Kai. Ageing Research Reviews. 2012;11(2):230-241. - PubMed
    1. Short-term calorie restriction protects against renal senescence of aged rats by increasing autophagic activity and reducing oxidative damage. Ning Yi-Chun, Cai Guang-Yan, Zhuo Li, Gao Jian-Jun, Dong Dan, Cui Shaoyuan, Feng Zhe, Shi Suo-Zhu, Bai Xue-Yuan, Sun Xue-Feng, Chen Xiang-Mei. Mechanisms of Ageing and Development. 2013;134(11-12):570-579. - PubMed
    1. Mild caloric restriction reduces blood pressure and activates endothelial AMPK-PI3K-Akt-eNOS pathway in obese Zucker rats. García-Prieto C.F., Pulido-Olmo H., Ruiz-Hurtado G., Gil-Ortega M., Aranguez I., Rubio M.A., Ruiz-Gayo M., Somoza B., Fernández-Alfonso M.S. Vascular Pharmacology. 2015;65-66:3-12. - PubMed

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