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. 2020 Mar 31;8(1):e106.
doi: 10.15190/d.2020.3.

An unusual case of aortic metastasis from lung cancer

Rodica Diaconu  1 , Roberta Florescu  2 , Anne Cornelissen  2 , Afify Mamdouh  2 , Nicole Schaaps  2 , Saskia von Stillfried  3 , Peter Boor  3 , Ruth Knüchel-Clarke  3 , Ionuț Donoiu  1 , Felix Vogt  2
Affiliations

An unusual case of aortic metastasis from lung cancer

Rodica Diaconu et al. Discoveries (Craiova). .

Abstract

In patients with cardiovascular events, such as myocardial infarction or aortic dissection without known risk factors for cardiovascular disease, neoplastic disease should be considered as a differential diagnosis. In this report, we present a case of a 51-year old man with previously undiagnosed non-small lung cancer leading to fatal cardiovascular complications due to hemovascular spread, diagnosed post-mortem. This case illustrates the value of autopsy in unexpected deaths.

Keywords: Autopsy; NSCLC; cardiovascular complications; cardiovascular disease; hemangiosis carcinomatosa.; non-small cell lung cancer.

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Conflict of interest statement

Conflict of interests: The authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1. Microscopic view of tumor cells in the lung (hematoxylin and eosin staining)
Red arrows point to neoplastic cells (scale bar, right panel: 50 μm).
Figure 2
Figure 2. Microscopic view of tumor cells in the aorta
Left panel: diffuse malignant infiltration of the vasa vasorum (hematoxylin and eosin staining; scale bar: 50 μm). Right panel: tumor cells in the aortic adventitia (hematoxylin and eosin staining; scale bar: 50 μm). Red arrows point to neoplastic cells.
Figure 3
Figure 3. Immunohistochemistry CK7 positive
Red arrows point to neoplastic cells; scale bar: 50 μm.
Figure 4
Figure 4. Immunohistochemistry CK20 negative
Red arrows point to neoplastic cells; scale bar: 50 μm.
Figure 5
Figure 5. Immunohistochemistry CDX2 negative
Red arrows point to neoplastic cells; scale bar: 50 μm.
Figure 6
Figure 6. Immunohistochemistry TIF1 positive
Red arrows point to neoplastic cells; scale bar: 50 μm.
See this image and copyright information in PMC

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